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Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function

The FASEB journal, 2021-05, Vol.35 (5), p.e21614-n/a

2021

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Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity

eLife, 2019-11, Vol.8

2019

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Recessively‐Inherited Adult‐Onset Alexander Disease Caused by a Homozygous Mutation in the GFAP Gene

Movement disorders, 2020-09, Vol.35 (9), p.1662-1667

2020

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Characterization of a panel of monoclonal antibodies recognizing specific epitopes on GFAP

PloS one, 2017-07, Vol.12 (7), p.e0180694-e0180694

2017

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The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP

Molecular biology of the cell, 2016-12, Vol.27 (25), p.3980-3990

2016

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The Relationship between Obesity-Related Factors and Graves' Orbitopathy: A Pilot Study

Medicina (Kaunas, Lithuania), 2022-11, Vol.58 (12), p.1748

2022

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The Alexander Disease–Causing Glial Fibrillary Acidic Protein Mutant, R416W, Accumulates into Rosenthal Fibers by a Pathway That Involves Filament Aggregation and the Association of αB-Crystallin and HSP27

American journal of human genetics, 2006-08, Vol.79 (2), p.197-213

2006

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Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo

Oxidative medicine and cellular longevity, 2020, Vol.2020 (2020), p.1-14

2020

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Granulocyte colony-stimulating factor reduces fibrosis in a mouse model of chronic pancreatitis

PloS one, 2014-12, Vol.9 (12), p.e116229-e116229

2014

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Insights into the beaded filament of the eye lens

Experimental cell research, 2007-06, Vol.313 (10), p.2180-2188

2007

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Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model

BMC neurology, 2017-09, Vol.17 (1), p.175-175, Article 175

2017

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Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation

ASN neuro, 2013-11, Vol.5 (5), p.e00125

2013

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Effects of Alexander disease-associated mutations on the assembly and organization of GFAP intermediate filaments

Molecular biology of the cell, 2022-07, Vol.33 (8), p.ar69

2022

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Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment

Science translational medicine, 2021-11, Vol.13 (620), p.eabg4711

2021

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Development of Fusion-Based Assay as a Drug Screening Platform for Nipah Virus Utilizing Baculovirus Expression Vector System

International journal of molecular sciences, 2024-08, Vol.25 (16), p.9102

2024

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A novel in-frame GFAP p.E138_L148del mutation in Type II Alexander disease with atypical phenotypes

European journal of human genetics : EJHG, 2022-06, Vol.30 (6), p.687-694

2022

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Purification of Protein Chaperones and Their Functional Assays with Intermediate Filaments

Methods in enzymology, 2016-01, Vol.569, p.155

2016

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Glial Fibrillary Acidic Protein Filaments Can Tolerate the Incorporation of Assembly-compromised GFAP-δ, but with Consequences for Filament Organization and αB-Crystallin Association

Molecular biology of the cell, 2008-10, Vol.19 (10), p.4521-4533

2008

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The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2013-05, Vol.368 (1617), p.20120375

2013

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Rhinacanthin C Alleviates Amyloid-β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells

Oxidative medicine and cellular longevity, 2017-01, Vol.2017 (2017), p.1-18

2017

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Production of Bivalent Subunit Vaccine for Porcine via 2A-Like Sequence in Baculovirus Expression Vector System

Processes, 2022-05, Vol.10 (5), p.895

2022

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The Behavior of Self-Monitoring of Blood Glucose and Glycemic Control in Taiwanese Population

Endocrines, 2022-05, Vol.3 (2), p.214-222

2022

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Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo

JAD reports, 2023-01, Vol.7 (1), p.51-76

2023

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Intermediate filament interactions can be altered by HSP27 and αB-crystallin

Journal of cell science, 1999-07, Vol.112 (13), p.2099-2112

1999

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Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability

Experimental cell research, 2011-10, Vol.317 (16), p.2252-2266

2011

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Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function

Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity

Recessively‐Inherited Adult‐Onset Alexander Disease Caused by a Homozygous Mutation in the GFAP Gene

Characterization of a panel of monoclonal antibodies recognizing specific epitopes on GFAP

The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP

The Relationship between Obesity-Related Factors and Graves' Orbitopathy: A Pilot Study

The Alexander Disease–Causing Glial Fibrillary Acidic Protein Mutant, R416W, Accumulates into Rosenthal Fibers by a Pathway That Involves Filament Aggregation and the Association of αB-Crystallin and HSP27

Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo

Granulocyte colony-stimulating factor reduces fibrosis in a mouse model of chronic pancreatitis

Insights into the beaded filament of the eye lens

Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model

Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation

Effects of Alexander disease-associated mutations on the assembly and organization of GFAP intermediate filaments

Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment

Development of Fusion-Based Assay as a Drug Screening Platform for Nipah Virus Utilizing Baculovirus Expression Vector System

A novel in-frame GFAP p.E138_L148del mutation in Type II Alexander disease with atypical phenotypes

Purification of Protein Chaperones and Their Functional Assays with Intermediate Filaments

Glial Fibrillary Acidic Protein Filaments Can Tolerate the Incorporation of Assembly-compromised GFAP-δ, but with Consequences for Filament Organization and αB-Crystallin Association

The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability

Rhinacanthin C Alleviates Amyloid-β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells

Production of Bivalent Subunit Vaccine for Porcine via 2A-Like Sequence in Baculovirus Expression Vector System

The Behavior of Self-Monitoring of Blood Glucose and Glycemic Control in Taiwanese Population

Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo

Intermediate filament interactions can be altered by HSP27 and αB-crystallin

Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability

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