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Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

Nature reviews. Drug discovery, 2009-02, Vol.8 (2), p.139-152

2009

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Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

The Journal of immunology (1950), 2010-07, Vol.185 (1), p.605-614

2010

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Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

Clinical cancer research, 2012-03, Vol.18 (5), p.1207-1213

2012

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Role of Mitochondrial Complex IV in Age-Dependent Obesity

Cell reports (Cambridge), 2016-09, Vol.16 (11), p.2991-3002

2016

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Synaptic activity‐induced glycolysis facilitates membrane lipid provision and neurite outgrowth

The EMBO journal, 2018-05, Vol.37 (9), p.n/a

2018

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Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity

International journal of molecular sciences, 2020-12, Vol.21 (24), p.9401

2020

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HIF1α-dependent uncoupling of glycolysis suppresses tumor cell proliferation

Cell reports (Cambridge), 2024-04, Vol.43 (4), p.114103-114103, Article 114103

2024

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Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles

International journal of molecular sciences, 2021-11, Vol.22 (23), p.12960

2021

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Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

Cell metabolism, 2011-12, Vol.14 (6), p.768-779

2011

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Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Nature genetics, 2008-02, Vol.40 (2), p.170-180

2008

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Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor

The Journal of immunology (1950), 2009-03, Vol.182 (5), p.3155-3164

2009

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IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis

Cell reports (Cambridge), 2023-12, Vol.42 (12), p.113508-113508, Article 113508

2023

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HIF Oxygen Sensing Pathways in Lung Biology

Biomedicines, 2018-06, Vol.6 (2), p.68

2018

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HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

Molecular cell, 2012-12, Vol.48 (5), p.681-691

2012

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Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

Gastroenterology (New York, N.Y. 1943), 2010-03, Vol.138 (3), p.1143-1154.e2

2010

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Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro

Redox biology, 2021-12, Vol.48, p.102171-102171, Article 102171

2021

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Hypoxia‐inducible factor 2α drives hepatosteatosis through the fatty acid translocase CD36

Liver international, 2020-10, Vol.40 (10), p.2553-2567

2020

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CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes

Oncoimmunology, 2017-04, Vol.6 (4), p.e1283468-e1283468

2017

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Erythroid SLC7A5/SLC3A2 amino acid carrier controls red blood cell size and maturation

iScience, 2023-01, Vol.26 (1), p.105739-105739, Article 105739

2023

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Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression

PloS one, 2011-07, Vol.6 (7), p.e22589

2011

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c-Jun and Hypoxia-Inducible Factor 1 Functionally Cooperate in Hypoxia-Induced Gene Transcription

Molecular and Cellular Biology, 2002-01, Vol.22 (1), p.12-22

2002

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Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease

Cardiovascular research, 2010-11, Vol.88 (2), p.219-228

2010

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The association of the angiopoietin/Tie-2 system with the development of metastasis and leukocyte migration in neuroendocrine tumors

Endocrine-related cancer, 2010-12, Vol.17 (4), p.897-908

2010

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Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

Role of Mitochondrial Complex IV in Age-Dependent Obesity

Synaptic activity‐induced glycolysis facilitates membrane lipid provision and neurite outgrowth

Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity

HIF1α-dependent uncoupling of glycolysis suppresses tumor cell proliferation

Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor

IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis

HIF Oxygen Sensing Pathways in Lung Biology

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro

HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis

Hypoxia‐inducible factor 2α drives hepatosteatosis through the fatty acid translocase CD36

CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes

Erythroid SLC7A5/SLC3A2 amino acid carrier controls red blood cell size and maturation

Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression

c-Jun and Hypoxia-Inducible Factor 1 Functionally Cooperate in Hypoxia-Induced Gene Transcription

Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease

The association of the angiopoietin/Tie-2 system with the development of metastasis and leukocyte migration in neuroendocrine tumors

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