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Discovery of a Potent, Orally Available, and Isoform-Selective Retinoic Acid β2 Receptor Agonist

Journal of medicinal chemistry, 2005-12, Vol.48 (24), p.7517-7519

2005

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Optimization of isochromanone based urotensin II receptor agonists

Bioorganic & medicinal chemistry, 2010-07, Vol.18 (13), p.4844-4854

2010

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Identification of novel subtype selective RAR agonists

Biochemical pharmacology, 2005-12, Vol.71 (1), p.156-162

2005

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Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2 mg/day, but does not enhance efficacy of haloperidol, 2 mg/day: Comparison with reference dose risperidone, 6 mg/day

Schizophrenia research, 2012-11, Vol.141 (2), p.144-152

2012

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Design, parallel synthesis and SAR of novel urotensin II receptor agonists

European journal of medicinal chemistry, 2007-02, Vol.42 (2), p.276-285

2007

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Design, Synthesis, and Structure−Activity Analysis of Isoform-Selective Retinoic Acid Receptor β Ligands

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1540-1545

2009

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Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine

Journal of medicinal chemistry, 1999-04, Vol.42 (7), p.1115-1122

1999

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Novel Potent and Efficacious Nonpeptidic Urotensin II Receptor Agonists

Journal of medicinal chemistry, 2006-04, Vol.49 (7), p.2232-2240

2006

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3-Heteroaryl-Substituted Quinuclidin-3-ol and Quinuclidin-2-ene Derivatives as Muscarinic Antagonists. Synthesis and Structure-Activity Relationships

Journal of medicinal chemistry, 1995-02, Vol.38 (3), p.473-487

1995

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Isochromanone-based urotensin-II receptor agonists

Bioorganic & medicinal chemistry, 2005-04, Vol.13 (8), p.3057-3068

2005

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Novel and potent small-molecule urotensin II receptor agonists

Bioorganic & medicinal chemistry, 2009-07, Vol.17 (13), p.4657-4665

2009

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(R)- and (S)-8-acetyl-2-(dipropylamino)tetralin (LY-41) : two novel 5-HT1A receptor agonists

European journal of pharmacology, 1993-01, Vol.231 (1), p.69-76

1993

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Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.4950-4953

2002

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Binding-site modeling of the muscarinic m1 receptor: a combination of homology-based and indirect approaches

Journal of medicinal chemistry, 1993-04, Vol.36 (8), p.967-976

1993

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Atropisomeric Derivatives of 2‘,6‘-Disubstituted (R)-11-Phenylaporphine: Selective Serotonin 5-HT7 Receptor Antagonists

Journal of medicinal chemistry, 2001-04, Vol.44 (9), p.1337-1340

2001

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Pharmacology of polymorphic variants of the human 5-HT1A receptor

Biochemical pharmacology, 2004-02, Vol.67 (3), p.479-490

2004

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Analysis of molecular determinants of affinity and relative efficacy of a series of R‐ and S‐2‐(dipropylamino)tetralins at the 5‐HT1A serotonin receptor

British journal of pharmacology, 2003-03, Vol.138 (6), p.1129-1139

2003

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Derivatives of (R)-1,11-Methyleneaporphine: Synthesis, Structure, and Interactions with G-Protein Coupled Receptors

Journal of medicinal chemistry, 2000-04, Vol.43 (7), p.1339-1349

2000

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Derivatives of 17-phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester : potential antiglaucoma agents

Journal of medicinal chemistry, 1995-01, Vol.38 (2), p.289-304

1995

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Antimuscarinic 3-(2-Furanyl)quinuclidin-2-ene Derivatives: Synthesis and Structure−Activity Relationships

Journal of medicinal chemistry, 1997-11, Vol.40 (23), p.3804-3819

1997

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Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase

Molecular pharmacology, 1991-06, Vol.39 (6), p.780-787

1991

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trans-2-Aryl-N,N-dipropylcyclopropylamines: Synthesis and Interactions with 5-HT1A Receptors

Journal of medicinal chemistry, 1996-03, Vol.39 (7), p.1485-1493

1996

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Interactions of ligands with active and inactive conformations of the dopamine D2 receptor

European journal of pharmacology, 1998-04, Vol.346 (2-3), p.299-307

1998

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Differential serotoninergic and dopaminergic activities of the (R) - and the (S) -enantiomers of 2-(di-n-propylamino) tetralin

European journal of pharmacology, 1996-05, Vol.303 (3), p.151-162

1996

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3-(2-Benzofuranyl)quinuclidin-2-ene Derivatives: Novel Muscarinic Antagonists

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3269-3277

1996

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Discovery of a Potent, Orally Available, and Isoform-Selective Retinoic Acid β2 Receptor Agonist

Optimization of isochromanone based urotensin II receptor agonists

Identification of novel subtype selective RAR agonists

Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2 mg/day, but does not enhance efficacy of haloperidol, 2 mg/day: Comparison with reference dose risperidone, 6 mg/day

Design, parallel synthesis and SAR of novel urotensin II receptor agonists

Design, Synthesis, and Structure−Activity Analysis of Isoform-Selective Retinoic Acid Receptor β Ligands

Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine

Novel Potent and Efficacious Nonpeptidic Urotensin II Receptor Agonists

3-Heteroaryl-Substituted Quinuclidin-3-ol and Quinuclidin-2-ene Derivatives as Muscarinic Antagonists. Synthesis and Structure-Activity Relationships

Isochromanone-based urotensin-II receptor agonists

Novel and potent small-molecule urotensin II receptor agonists

(R)- and (S)-8-acetyl-2-(dipropylamino)tetralin (LY-41) : two novel 5-HT1A receptor agonists

Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Binding-site modeling of the muscarinic m1 receptor: a combination of homology-based and indirect approaches

Atropisomeric Derivatives of 2‘,6‘-Disubstituted (R)-11-Phenylaporphine: Selective Serotonin 5-HT7 Receptor Antagonists

Pharmacology of polymorphic variants of the human 5-HT1A receptor

Analysis of molecular determinants of affinity and relative efficacy of a series of R‐ and S‐2‐(dipropylamino)tetralins at the 5‐HT1A serotonin receptor

Derivatives of (R)-1,11-Methyleneaporphine: Synthesis, Structure, and Interactions with G-Protein Coupled Receptors

Derivatives of 17-phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester : potential antiglaucoma agents

Antimuscarinic 3-(2-Furanyl)quinuclidin-2-ene Derivatives: Synthesis and Structure−Activity Relationships

Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase

trans-2-Aryl-N,N-dipropylcyclopropylamines: Synthesis and Interactions with 5-HT1A Receptors

Interactions of ligands with active and inactive conformations of the dopamine D2 receptor

Differential serotoninergic and dopaminergic activities of the (R) - and the (S) -enantiomers of 2-(di-n-propylamino) tetralin

3-(2-Benzofuranyl)quinuclidin-2-ene Derivatives: Novel Muscarinic Antagonists

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