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Arylamine N‐acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery

British journal of pharmacology, 2014-06, Vol.171 (11), p.2705-2725

2014

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NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review

PloS one, 2023-04, Vol.18 (4), p.e0283726-e0283726

2023

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Genetic and small molecule inhibition of arylamine N‐acetyltransferase 1 reduces anchorage‐independent growth in human breast cancer cell line MDA‐MB‐231

Molecular carcinogenesis, 2018-04, Vol.57 (4), p.549-558

2018

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Deletion of arylamine N‐acetyltransferase 1 in MDA‐MB‐231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis

Molecular carcinogenesis, 2022-05, Vol.61 (5), p.481-493

2022

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Arylamine N‐acetyltransferases: a structural perspective

British journal of pharmacology, 2013-06, Vol.169 (4), p.748-760

2013

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Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells

Toxicology and applied pharmacology, 2022-05, Vol.442, p.115993-115993, Article 115993

2022

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CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism

Scientific reports, 2020-06, Vol.10 (1), p.9804, Article 9804

2020

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Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex

The international journal of biochemistry & cell biology, 2019-05, Vol.110, p.84-90

2019

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A readout of metabolic efficiency in arylamine N‐acetyltransferase‐deficient mice reveals minor energy metabolism changes

FEBS letters, 2019-04, Vol.593 (8), p.831-841

2019

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Knockout of human arylamine N‐acetyltransferase 1 (NAT1) in MDA‐MB‐231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity

Molecular carcinogenesis, 2018-11, Vol.57 (11), p.1458-1466

2018

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Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes

Scientific reports, 2020-05, Vol.10 (1), p.7566, Article 7566

2020

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Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability

PloS one, 2018-03, Vol.13 (3), p.e0193560-e0193560

2018

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Altered Arylamine N-acetyltransferase 1 and miR-1290 Levels in Childhood Acute Lymphoblastic Leukemia: A Pilot Study

In vivo (Athens), 2023-05, Vol.37 (3), p.1129-1144

2023

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A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy

Antimicrobial agents and chemotherapy, 2016-10, Vol.60 (10), p.6134-6145

2016

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Population variability of rhesus macaque (Macaca mulatta) NAT1 gene for arylamine N-acetyltransferase 1: Functional effects and comparison with human

Scientific reports, 2019-07, Vol.9 (1), p.10937-15, Article 10937

2019

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Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition

Acta crystallographica. Section D, Biological crystallography., 2014-11, Vol.70 (11), p.3066-3079

2014

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Arylamine N-acetyltransferase 1: a novel drug target in cancer development

Pharmacological reviews, 2012-01, Vol.64 (1), p.147-165

2012

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Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells

Cell reports (Cambridge), 2020-06, Vol.31 (9), p.107715-107715, Article 107715

2020

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Modulation of Human Arylamine N -Acetyltransferase 1 Activity by Lysine Acetylation: Role of p300/CREB-Binding Protein and Sirtuins 1 and 2

Molecular pharmacology, 2020-08, Vol.98 (2), p.88-95

2020

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Sex, ethnicity, and slow acetylator profile are the major causes of hepatotoxicity induced by antituberculosis drugs

Journal of gastroenterology and hepatology, 2013-02, Vol.28 (2), p.323-328

2013

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Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity

Acta crystallographica. Section D, Biological crystallography., 2013-08, Vol.69 (8), p.1433-1446

2013

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Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice

Cell reports (Cambridge), 2016-10, Vol.17 (2), p.527-540

2016

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Molecular and Functional Characterization of N‑Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque

Chemical research in toxicology, 2018-11, Vol.31 (11), p.1269-1276

2018

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NAT2 knockdown inhibits the development of colorectal cancer and its clinical significance

European review for medical and pharmacological sciences, 2021-05, Vol.25 (9), p.3460

2021

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Arylamine N‐acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review

Genetic and small molecule inhibition of arylamine N‐acetyltransferase 1 reduces anchorage‐independent growth in human breast cancer cell line MDA‐MB‐231

Deletion of arylamine N‐acetyltransferase 1 in MDA‐MB‐231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis

Arylamine N‐acetyltransferases: a structural perspective

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells

CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism

Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex

A readout of metabolic efficiency in arylamine N‐acetyltransferase‐deficient mice reveals minor energy metabolism changes

Knockout of human arylamine N‐acetyltransferase 1 (NAT1) in MDA‐MB‐231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity

Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes

Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability

Altered Arylamine N-acetyltransferase 1 and miR-1290 Levels in Childhood Acute Lymphoblastic Leukemia: A Pilot Study

A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy

Population variability of rhesus macaque (Macaca mulatta) NAT1 gene for arylamine N-acetyltransferase 1: Functional effects and comparison with human

Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition

Arylamine N-acetyltransferase 1: a novel drug target in cancer development

Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells

Modulation of Human Arylamine N -Acetyltransferase 1 Activity by Lysine Acetylation: Role of p300/CREB-Binding Protein and Sirtuins 1 and 2

Sex, ethnicity, and slow acetylator profile are the major causes of hepatotoxicity induced by antituberculosis drugs

Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity

Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice

Molecular and Functional Characterization of N‑Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque

NAT2 knockdown inhibits the development of colorectal cancer and its clinical significance

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