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Substance P Increases Sympathetic Activity During Combined Angiotensin-Converting Enzyme and Dipeptidyl Peptidase-4 Inhibition

Hypertension (Dallas, Tex. 1979), 2014-05, Vol.63 (5), p.951-957

2014

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Inhibition of soluble epoxide hydrolase counteracts the development of renal dysfunction and progression of congestive heart failure in Ren-2 transgenic hypertensive rats with aorto-caval fistula

Clinical and experimental pharmacology & physiology, 2015-07, Vol.42 (7), p.795-807

2015

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Evaluation of the in vitro/in vivo drug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition

Food and chemical toxicology, 2014-06, Vol.68, p.117-127

2014

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Peony-Glycyrrhiza Decoction, an Herbal Preparation, Inhibits Clozapine Metabolism via Cytochrome P450s, but Not Flavin-Containing Monooxygenase in In Vitro Models

Drug metabolism and disposition, 2015-07, Vol.43 (7), p.1147-1153

2015

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Nuclear angiotensin-(1-7) receptor is functionally coupled to the formation of nitric oxide

American Journal of Physiology - Renal Physiology, 2010-11, Vol.299 (5), p.F983-F990

2010

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Inhibition of in vitro metabolism of testosterone in human, dog and horse liver microsomes to investigate species differences

Toxicology in vitro, 2015-04, Vol.29 (3), p.468-478

2015

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Association of angiotensin-converting enzyme inhibitors and serum lipids with plaque regression in cardiac allograft vasculopathy

Transplantation, 2006-10, Vol.82 (8), p.1108-1111

2006

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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Nature (London), 2014-04, Vol.508 (7495), p.215-221

2014

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Regorafenib (BAY 73‐4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

International journal of cancer, 2011-07, Vol.129 (1), p.245-255

2011

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Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (13), p.E1796-E1805

2016

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Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response

Experimental hematology, 2007-10, Vol.35 (10), p.1527-1537

2007

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Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

Nature (London), 2018-07, Vol.559 (7712), p.125-129

2018

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Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)‑3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)‑ol (GSK656)

Journal of medicinal chemistry, 2017-10, Vol.60 (19), p.8011-8026

2017

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Baseline co-medications may alter the anti-tumoural effect of checkpoint inhibitors as well as the risk of immune-related adverse events

European journal of cancer (1990), 2021-11, Vol.157, p.474-484

2021

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Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)‑1-((S)‑2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy‑N‑(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.599-618

2018

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First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia

Journal of clinical oncology, 2020-12, Vol.38 (36), p.4260-4273

2020

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Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy

Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (13), p.7374-7381

2020

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The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Nature (London), 2018-11, Vol.563 (7732), p.564-568

2018

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Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

Cancer cell, 2013-09, Vol.24 (3), p.379-393

2013

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PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects

International journal of molecular sciences, 2020-12, Vol.22 (1), p.173

2020

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Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents

European journal of medicinal chemistry, 2020-01, Vol.186, p.111863, Article 111863

2020

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Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications

JNCI : Journal of the National Cancer Institute, 2019-06, Vol.111 (6), p.584-596

2019

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Differential Effects of Omeprazole and Pantoprazole on the Pharmacodynamics and Pharmacokinetics of Clopidogrel in Healthy Subjects: Randomized, Placebo-Controlled, Crossover Comparison Studies

Clinical pharmacology and therapeutics, 2011-01, Vol.89 (1), p.65-74

2011

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Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

Science translational medicine, 2016-10, Vol.8 (362), p.362ps17

2016

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Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial

JAMA : the journal of the American Medical Association, 2023-04, Vol.329 (14), p.1183

2023

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Substance P Increases Sympathetic Activity During Combined Angiotensin-Converting Enzyme and Dipeptidyl Peptidase-4 Inhibition

Inhibition of soluble epoxide hydrolase counteracts the development of renal dysfunction and progression of congestive heart failure in Ren-2 transgenic hypertensive rats with aorto-caval fistula

Evaluation of the in vitro/in vivo drug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition

Peony-Glycyrrhiza Decoction, an Herbal Preparation, Inhibits Clozapine Metabolism via Cytochrome P450s, but Not Flavin-Containing Monooxygenase in In Vitro Models

Nuclear angiotensin-(1-7) receptor is functionally coupled to the formation of nitric oxide

Inhibition of in vitro metabolism of testosterone in human, dog and horse liver microsomes to investigate species differences

Association of angiotensin-converting enzyme inhibitors and serum lipids with plaque regression in cardiac allograft vasculopathy

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Regorafenib (BAY 73‐4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)‑3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)‑ol (GSK656)

Baseline co-medications may alter the anti-tumoural effect of checkpoint inhibitors as well as the risk of immune-related adverse events

First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia

Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects

Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents

Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications

Differential Effects of Omeprazole and Pantoprazole on the Pharmacodynamics and Pharmacokinetics of Clopidogrel in Healthy Subjects: Randomized, Placebo-Controlled, Crossover Comparison Studies

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial

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