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3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line

Bioorganic & medicinal chemistry, 2020-02, Vol.28 (4), p.115300, Article 115300

2020

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The research progress in and perspective of potential fungicides: Succinate dehydrogenase inhibitors

Bioorganic & medicinal chemistry, 2021-11, Vol.50, p.116476-116476, Article 116476

2021

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Discovery of aromatic 2-(3-(methylcarbamoyl) guanidino)-N-aylacetamides as highly potent chitinase inhibitors

Bioorganic & medicinal chemistry, 2023-02, Vol.80, p.117172-117172, Article 117172

2023

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Syntheses of coumarin–tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase

Bioorganic & medicinal chemistry, 2014-09, Vol.22 (17), p.4784-4791

2014

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There’s more to enzyme antagonism than inhibition

Bioorganic & medicinal chemistry, 2023-03, Vol.82, p.117231-117231, Article 117231

2023

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CYPlebrity: Machine learning models for the prediction of inhibitors of cytochrome P450 enzymes

Bioorganic & medicinal chemistry, 2021-09, Vol.46, p.116388-116388, Article 116388

2021

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The tyrosinase inhibitory effects of isoxazolone derivatives with a (Z)-β-phenyl-α, β-unsaturated carbonyl scaffold

Bioorganic & medicinal chemistry, 2018-08, Vol.26 (14), p.3882-3889

2018

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The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments

Bioorganic & medicinal chemistry, 2014-08, Vol.22 (16), p.4462-4473

2014

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Design, synthesis, and anti-melanogenic efficacy of 2-mercaptobenzoxazoles with nanomolar tyrosinase activity inhibition

Bioorganic & medicinal chemistry, 2024-08, Vol.110, p.117832, Article 117832

2024

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Design, synthesis and evaluation of carbamate-linked uridyl-based inhibitors of human ST6Gal I

Bioorganic & medicinal chemistry, 2020-07, Vol.28 (14), p.115561-115561, Article 115561

2020

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Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase

Bioorganic & medicinal chemistry, 2021-12, Vol.52, p.116518-116518, Article 116518

2021

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A versatile toolbox for investigating biological processes based on quinone methide chemistry: From self-immolative linkers to self-immobilizing agents

Bioorganic & medicinal chemistry, 2021-08, Vol.44, p.116281-116281, Article 116281

2021

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Synthesis and evaluation of squaramide and thiosquaramide inhibitors of the DNA repair enzyme SNM1A

Bioorganic & medicinal chemistry, 2021-09, Vol.46, p.116369-116369, Article 116369

2021

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Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers

Bioorganic & medicinal chemistry, 2016-02, Vol.24 (4), p.578-587

2016

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Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity

Bioorganic & medicinal chemistry, 2021-09, Vol.46, p.116352-116352, Article 116352

2021

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Pyrrolomycins as antimicrobial agents. Microwave-assisted organic synthesis and insights into their antimicrobial mechanism of action

Bioorganic & medicinal chemistry, 2019-03, Vol.27 (5), p.721-728

2019

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Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors

Bioorganic & medicinal chemistry, 2021-08, Vol.44, p.116294-116294, Article 116294

2021

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Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (8), p.1658-1669

2019

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Discovery and biological evaluation of novel dual PTP1B and ACP1 inhibitors for the treatment of insulin resistance

Bioorganic & medicinal chemistry, 2024-01, Vol.97, p.117545-117545, Article 117545

2024

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Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy

Bioorganic & medicinal chemistry, 2019-03, Vol.27 (6), p.1119-1129

2019

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Thiazolidine-2,4-diones: Progress towards multifarious applications

Bioorganic & medicinal chemistry, 2013-04, Vol.21 (7), p.1599-1620

2013

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Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

Bioorganic & medicinal chemistry, 2021-05, Vol.37, p.116093-116093, Article 116093

2021

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Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors

Bioorganic & medicinal chemistry, 2016-03, Vol.24 (5), p.1050-1062

2016

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Thiazol-4(5H)-one analogs as potent tyrosinase inhibitors: Synthesis, tyrosinase inhibition, antimelanogenic effect, antioxidant activity, and in silico docking simulation

Bioorganic & medicinal chemistry, 2024-01, Vol.98, p.117578-117578, Article 117578

2024

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Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors—A review of the triketone chemistry story from a Syngenta perspective

Bioorganic & medicinal chemistry, 2009-06, Vol.17 (12), p.4134-4152

2009

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3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line

The research progress in and perspective of potential fungicides: Succinate dehydrogenase inhibitors

Discovery of aromatic 2-(3-(methylcarbamoyl) guanidino)-N-aylacetamides as highly potent chitinase inhibitors

Syntheses of coumarin–tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase

There’s more to enzyme antagonism than inhibition

CYPlebrity: Machine learning models for the prediction of inhibitors of cytochrome P450 enzymes

The tyrosinase inhibitory effects of isoxazolone derivatives with a (Z)-β-phenyl-α, β-unsaturated carbonyl scaffold

The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments

Design, synthesis, and anti-melanogenic efficacy of 2-mercaptobenzoxazoles with nanomolar tyrosinase activity inhibition

Design, synthesis and evaluation of carbamate-linked uridyl-based inhibitors of human ST6Gal I

Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase

A versatile toolbox for investigating biological processes based on quinone methide chemistry: From self-immolative linkers to self-immobilizing agents

Synthesis and evaluation of squaramide and thiosquaramide inhibitors of the DNA repair enzyme SNM1A

Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers

Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity

Pyrrolomycins as antimicrobial agents. Microwave-assisted organic synthesis and insights into their antimicrobial mechanism of action

Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors

Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors

Discovery and biological evaluation of novel dual PTP1B and ACP1 inhibitors for the treatment of insulin resistance

Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy

Thiazolidine-2,4-diones: Progress towards multifarious applications

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors

Thiazol-4(5H)-one analogs as potent tyrosinase inhibitors: Synthesis, tyrosinase inhibition, antimelanogenic effect, antioxidant activity, and in silico docking simulation

Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors—A review of the triketone chemistry story from a Syngenta perspective

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