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New Mechanism of Gemcitabine and Its Phosphates: DNA Polymerization Disruption via 3′–5′ Exonuclease Inhibition

Biochemistry (Easton), 2020-11, Vol.59 (45), p.4344-4352

2020

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Crystallographic and molecular-modeling studies of lipase B from Candida antarctica reveal a stereospecificity pocket for secondary alcohols

Biochemistry (Easton), 1995-12, Vol.34 (51), p.16838-16851

1995

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Why Are Lopinavir and Ritonavir Effective against the Newly Emerged Coronavirus 2019? Atomistic Insights into the Inhibitory Mechanisms

Biochemistry (Easton), 2020-05, Vol.59 (18), p.1769-1779

2020

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Crystal Structure of a Complex between the Actinomadura R39 dd-Peptidase and a Peptidoglycan-mimetic Boronate Inhibitor: Interpretation of a Transition State Analogue in Terms of Catalytic Mechanism

Biochemistry (Easton), 2010-08, Vol.49 (30), p.6411-6419

2010

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Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent, Broad-Spectrum Inhibitor

Biochemistry (Easton), 2000-04, Vol.39 (15), p.4288-4298

2000

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Tuning of Peroxiredoxin Catalysis for Various Physiological Roles

Biochemistry (Easton), 2014-12, Vol.53 (49), p.7693-7705

2014

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Inhibition of Transforming Growth Factor-β Signaling by Low Molecular Weight Compounds Interfering with ATP- or Substrate-Binding Sites of the TGFβ Type I Receptor Kinase

Biochemistry (Easton), 2002-09, Vol.41 (36), p.11000-11007

2002

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Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

Biochemistry (Easton), 2019-02, Vol.58 (5), p.391-400

2019

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Anticancer Drugs of Lysine Specific Histone Demethylase‑1 (LSD1) Display Variable Inhibition on Nucleosome Substrates

Biochemistry (Easton), 2024-06, Vol.63 (11), p.1369-1375

2024

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Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin

Biochemistry (Easton), 2024-05, Vol.63 (10), p.1241-1245

2024

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Urease Inhibition in the Presence of N‑(n‑Butyl)thiophosphoric Triamide, a Suicide Substrate: Structure and Kinetics

Biochemistry (Easton), 2017-10, Vol.56 (40), p.5391-5404

2017

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Structurally Designed trans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1

Biochemistry (Easton), 2010-08, Vol.49 (30), p.6494-6503

2010

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Stimulation of Topoisomerase II-Mediated DNA Cleavage by Three DNA-Intercalating Plant Alkaloids: Cryptolepine, Matadine, and Serpentine

Biochemistry (Easton), 1999-06, Vol.38 (24), p.7719-7726

1999

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Specificity Distorted: Chemical Induction of Biological Paracatalysis

Biochemistry (Easton), 2020-09, Vol.59 (38), p.3517-3522

2020

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Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A

Biochemistry (Easton), 2021-03, Vol.60 (10), p.791-801

2021

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Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases

Biochemistry (Easton), 2018-04, Vol.57 (16), p.2383-2393

2018

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Slow-Binding Inhibition of Mycobacterium tuberculosis Shikimate Kinase by Manzamine Alkaloids

Biochemistry (Easton), 2018-08, Vol.57 (32), p.4923-4933

2018

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Mechanistic Insights into a DMSO-Perturbing Inhibitory Assay of Hyaluronidase

Biochemistry (Easton), 2020-10, Vol.59 (40), p.3879-3888

2020

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Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity

Biochemistry (Easton), 2007-11, Vol.46 (45), p.13019-13030

2007

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Irreversible Inhibition of the Mycobacterium tuberculosis β-Lactamase by Clavulanate

Biochemistry (Easton), 2007-10, Vol.46 (43), p.11998-12004

2007

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Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer’s Disease

Biochemistry (Easton), 2020-07, Vol.59 (28), p.2585-2591

2020

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Alzheimer's Amyloid Precursor Protein α-Secretase Is Inhibited by Hydroxamic Acid-Based Zinc Metalloprotease Inhibitors: Similarities to the Angiotensin Converting Enzyme Secretase

Biochemistry (Easton), 1998-02, Vol.37 (6), p.1680-1685

1998

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Targeting the Unique Mechanism of Bacterial 1‑Deoxy‑d‑xylulose-5-phosphate Synthase

Biochemistry (Easton), 2018-07, Vol.57 (29), p.4349-4356

2018

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New Glucosidase Inhibitors from an Ayurvedic Herbal Treatment for Type 2 Diabetes: Structures and Inhibition of Human Intestinal Maltase-Glucoamylase with Compounds from Salacia reticulata

Biochemistry (Easton), 2010-01, Vol.49 (3), p.443-451

2010

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Structural Dissection of Helianthamide Reveals the Basis of Its Potent Inhibition of Human Pancreatic α‑Amylase

Biochemistry (Easton), 2018-09, Vol.57 (37), p.5384-5387

2018

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New Mechanism of Gemcitabine and Its Phosphates: DNA Polymerization Disruption via 3′–5′ Exonuclease Inhibition

Crystallographic and molecular-modeling studies of lipase B from Candida antarctica reveal a stereospecificity pocket for secondary alcohols

Why Are Lopinavir and Ritonavir Effective against the Newly Emerged Coronavirus 2019? Atomistic Insights into the Inhibitory Mechanisms

Crystal Structure of a Complex between the Actinomadura R39 dd-Peptidase and a Peptidoglycan-mimetic Boronate Inhibitor: Interpretation of a Transition State Analogue in Terms of Catalytic Mechanism

Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent, Broad-Spectrum Inhibitor

Tuning of Peroxiredoxin Catalysis for Various Physiological Roles

Inhibition of Transforming Growth Factor-β Signaling by Low Molecular Weight Compounds Interfering with ATP- or Substrate-Binding Sites of the TGFβ Type I Receptor Kinase

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

Anticancer Drugs of Lysine Specific Histone Demethylase‑1 (LSD1) Display Variable Inhibition on Nucleosome Substrates

Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin

Urease Inhibition in the Presence of N‑(n‑Butyl)thiophosphoric Triamide, a Suicide Substrate: Structure and Kinetics

Structurally Designed trans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1

Stimulation of Topoisomerase II-Mediated DNA Cleavage by Three DNA-Intercalating Plant Alkaloids: Cryptolepine, Matadine, and Serpentine

Specificity Distorted: Chemical Induction of Biological Paracatalysis

Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A

Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases

Slow-Binding Inhibition of Mycobacterium tuberculosis Shikimate Kinase by Manzamine Alkaloids

Mechanistic Insights into a DMSO-Perturbing Inhibitory Assay of Hyaluronidase

Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity

Irreversible Inhibition of the Mycobacterium tuberculosis β-Lactamase by Clavulanate

Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer’s Disease

Alzheimer's Amyloid Precursor Protein α-Secretase Is Inhibited by Hydroxamic Acid-Based Zinc Metalloprotease Inhibitors: Similarities to the Angiotensin Converting Enzyme Secretase

Targeting the Unique Mechanism of Bacterial 1‑Deoxy‑d‑xylulose-5-phosphate Synthase

New Glucosidase Inhibitors from an Ayurvedic Herbal Treatment for Type 2 Diabetes: Structures and Inhibition of Human Intestinal Maltase-Glucoamylase with Compounds from Salacia reticulata

Structural Dissection of Helianthamide Reveals the Basis of Its Potent Inhibition of Human Pancreatic α‑Amylase

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