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Proteomics-based target identification of natural products affecting cancer metabolism

Journal of antibiotics, 2021-10, Vol.74 (10), p.639-650

2021

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Two-dimensional electrophoresis-cellular thermal shift assay (2DE-CETSA) for target identification of bioactive compounds

Methods in enzymology, 2022-01, Vol.675, p.425-437

2022

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Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA

Cell chemical biology, 2020-02, Vol.27 (2), p.186-196.e4

2020

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Proteomic Profiling for Target Identification of Biologically Active Small Molecules Using 2D DIGE

Methods in molecular biology (Clifton, N.J.), 2019, Vol.1888, p.127

2019

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Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival

Scientific reports, 2016-05, Vol.6 (1), p.26521-26521, Article 26521

2016

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Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana

Scientific reports, 2021-10, Vol.11 (1), p.21109-11, Article 21109

2021

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Target identification of small molecules based on chemical biology approaches

Molecular bioSystems, 2013-05, Vol.9 (5), p.897-914

2013

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Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase

Natural product reports, 2016-05, Vol.33 (5), p.621-625

2016

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Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice

Journal of cellular and molecular medicine, 2019-09, Vol.23 (9), p.6283-6294

2019

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Methyl 3‑((6-Methoxy-1,4-dihydroindeno[1,2‑c]pyrazol-3-yl)amino)benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods

Journal of medicinal chemistry, 2015-05, Vol.58 (10), p.4230-4241

2015

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Allantopyrone A activates Keap1-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death

Journal of antibiotics, 2017-04, Vol.70 (4), p.429-434

2017

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Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics

Bioscience, biotechnology, and biochemistry, 2020-12, Vol.84 (12), p.2484-2490

2020

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Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34

Angewandte Chemie International Edition, 2017-07, Vol.56 (28), p.8153-8157

International ed. in English, 2017

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A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition

FEBS letters, 2019-04, Vol.593 (8), p.763-776

2019

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Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana

Scientific reports, 2020-05, Vol.10 (1), p.8691-8691, Article 8691

2020

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Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein

ACS chemical biology, 2012-05, Vol.7 (5), p.892-900

2012

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Proteomics accelerating the identification of the target molecule of bioactive small molecules

Current opinion in chemical biology, 2011-02, Vol.15 (1), p.57-65

2011

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Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Angewandte Chemie (International ed.), 2005-06, Vol.44 (23), p.3559-3562

2005

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Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry

Bio-protocol, 2020-02, Vol.10 (3), p.e3517-e3517

2020

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Terpendole E and its Derivative Inhibit STLC- and GSK-1-Resistant Eg5

Chembiochem : a European journal of chemical biology, 2014-05, Vol.15 (7), p.934-938

2014

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Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress

Heliyon, 2020-10, Vol.6 (10), p.e05200-e05200, Article e05200

2020

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Corrigendum to “Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress” [Heliyon 6 (10) (October 2020) e05200]

Heliyon, 2021-02, Vol.7 (2), p.e05907-e05907, Article e05907

2021

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Measurement of ATPase Activity of Valosin-containing Protein/p97

Bio-protocol, 2020-02, Vol.10 (3), p.e3516-e3516

2020

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Iejimalides show anti-osteoclast activity via V-ATPase inhibition

Bioscience, biotechnology, and biochemistry, 2006-06, Vol.70 (6), p.1364-1370

2006

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Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells

Bioorganic & medicinal chemistry, 2012-06, Vol.20 (12), p.3799-3806

2012

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Proteomics-based target identification of natural products affecting cancer metabolism

Two-dimensional electrophoresis-cellular thermal shift assay (2DE-CETSA) for target identification of bioactive compounds

Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA

Proteomic Profiling for Target Identification of Biologically Active Small Molecules Using 2D DIGE

Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival

Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana

Target identification of small molecules based on chemical biology approaches

Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase

Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice

Methyl 3‑((6-Methoxy-1,4-dihydroindeno[1,2‑c]pyrazol-3-yl)amino)benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods

Allantopyrone A activates Keap1-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death

Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics

Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34

A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition

Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana

Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein

Proteomics accelerating the identification of the target molecule of bioactive small molecules

Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry

Terpendole E and its Derivative Inhibit STLC- and GSK-1-Resistant Eg5

Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress

Corrigendum to “Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress” [Heliyon 6 (10) (October 2020) e05200]

Measurement of ATPase Activity of Valosin-containing Protein/p97

Iejimalides show anti-osteoclast activity via V-ATPase inhibition

Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells

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