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Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro

Scientific reports, 2021-06, Vol.11 (1), p.13317-13317, Article 13317

2021

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Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6‑Oxopurine Phosphoribosyltransferases

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.4030-4057

2022

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Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6‑Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents

Journal of medicinal chemistry, 2015-01, Vol.58 (2), p.827-846

2015

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Helicobacter pylori Xanthine–Guanine–Hypoxanthine PhosphoribosyltransferaseA Putative Target for Drug Discovery against Gastrointestinal Tract Infections

Journal of medicinal chemistry, 2021-05, Vol.64 (9), p.5710-5729

2021

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Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases

Journal of medicinal chemistry, 2012-07, Vol.55 (13), p.6209-6223

2012

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Hypoxanthine-Guanine Phosphoribosyltransferase Is Dispensable for Mycobacterium smegmatis Viability

Journal of bacteriology, 2020-02, Vol.202 (5)

2020

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First Crystal Structures of Mycobacterium tuberculosis 6‑Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity

Journal of medicinal chemistry, 2015-06, Vol.58 (11), p.4822-4838

2015

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Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine–Guanine–(Xanthine) Phosphoribosyltransferase

Journal of medicinal chemistry, 2017-09, Vol.60 (17), p.7539-7554

2017

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Acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group Are Potent Inhibitors of 6‑Oxopurine Phosphoribosyltransferases and Have Antimalarial Activity

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2513-2526

2013

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Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery

PLoS neglected tropical diseases, 2018-02, Vol.12 (2), p.e0006301

2018

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5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidinesAcyclic Nucleoside Phosphonate Analogues with Antiviral Activity

Journal of medicinal chemistry, 2003-11, Vol.46 (23), p.5064-5073

2003

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Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP

The FEBS journal, 2019-12, Vol.286 (23), p.4721-4736

2019

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N2′‐Branched Acyclic Nucleoside Phosphonates Containing 9‐Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6‐Oxopurine Phosphoribosyltransferase

ChemMedChem, 2023-08, Vol.18 (15), p.e202300211-n/a

2023

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Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial Therapeutics

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4391-4399

2009

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Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics

ACS chemical biology, 2018-01, Vol.13 (1), p.82-90

2018

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Inhibition of the Escherichia coli 6‑Oxopurine Phosphoribosyltransferases by Nucleoside Phosphonates: Potential for New Antibacterial Agents

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.6967-6984

2013

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Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase

Scientific reports, 2016-10, Vol.6 (1), p.35894-35894, Article 35894

2016

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Acyclic Nucleoside Phosphonates Containing 9‐Deazahypoxanthine and a Five‐Membered Heterocycle as Selective Inhibitors of Plasmodial 6‐Oxopurine Phosphoribosyltransferases

ChemMedChem, 2017-07, Vol.12 (14), p.1133-1141

2017

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6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs

Current topics in medicinal chemistry, 2011-08, Vol.11 (16), p.2085

2011

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N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides

Organic & biomolecular chemistry, 2015-04, Vol.13 (15), p.4449-4458

2015

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Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases

ChemMedChem, 2015-10, Vol.10 (10), p.1707-1723

2015

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Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic Acids

European Journal of Organic Chemistry, 2010-05, Vol.2010 (15), p.2885-2892

2010

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Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase

ChemistrySelect (Weinheim), 2016-11, Vol.1 (19), p.6267-6276

2016

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N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotidesElectronic supplementary information (ESI) available. See DOI: 10.1039/c4ob02265c

2015-03

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Crystal structures of Trypanosoma brucei hypoxanthine-guanine-xanthine phosphoribosyltransferase

Acta crystallographica. Section A, Foundations and advances, 2016-08, Vol.72 (a1), p.s207-s207

2016

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Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro

Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6‑Oxopurine Phosphoribosyltransferases

Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6‑Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents

Helicobacter pylori Xanthine–Guanine–Hypoxanthine PhosphoribosyltransferaseA Putative Target for Drug Discovery against Gastrointestinal Tract Infections

Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases

Hypoxanthine-Guanine Phosphoribosyltransferase Is Dispensable for Mycobacterium smegmatis Viability

First Crystal Structures of Mycobacterium tuberculosis 6‑Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity

Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine–Guanine–(Xanthine) Phosphoribosyltransferase

Acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group Are Potent Inhibitors of 6‑Oxopurine Phosphoribosyltransferases and Have Antimalarial Activity

Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery

5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidinesAcyclic Nucleoside Phosphonate Analogues with Antiviral Activity

Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP

N2′‐Branched Acyclic Nucleoside Phosphonates Containing 9‐Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6‐Oxopurine Phosphoribosyltransferase

Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial Therapeutics

Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics

Inhibition of the Escherichia coli 6‑Oxopurine Phosphoribosyltransferases by Nucleoside Phosphonates: Potential for New Antibacterial Agents

Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase

Acyclic Nucleoside Phosphonates Containing 9‐Deazahypoxanthine and a Five‐Membered Heterocycle as Selective Inhibitors of Plasmodial 6‐Oxopurine Phosphoribosyltransferases

6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs

N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides

Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases

Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic Acids

Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase

N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotidesElectronic supplementary information (ESI) available. See DOI: 10.1039/c4ob02265c

Crystal structures of Trypanosoma brucei hypoxanthine-guanine-xanthine phosphoribosyltransferase

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