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A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites

PLoS pathogens, 2023-07, Vol.19 (7), p.e1011517-e1011517

2023

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A novel heteromeric pantothenate kinase complex in apicomplexan parasites

PLoS pathogens, 2021-07, Vol.17 (7), p.e1009797-e1009797

2021

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Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated

PloS one, 2013-02, Vol.8 (2), p.e54974-e54974

2013

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Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides

Biochemical Society transactions, 2014-08, Vol.42 (4), p.1087

2014

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Correction: A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites

PLoS pathogens, 2024-02, Vol.20 (2), p.e1011987-e1011987

2024

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Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

PLoS pathogens, 2018-04, Vol.14 (4), p.e1006918-e1006918

2018

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Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides

International journal for parasitology -- drugs and drug resistance, 2024-08, Vol.25, p.100536-100536, Article 100536

2024

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The Human Malaria Parasite Plasmodium falciparum Is Not Dependent on Host Coenzyme A Biosynthesis

The Journal of biological chemistry, 2009-09, Vol.284 (37), p.24904-24913

2009

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Coenzyme A biosynthesis: an antimicrobial drug target

FEMS microbiology reviews, 2008, Vol.32 (1), p.56-106

2008

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Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target

International journal for parasitology -- drugs and drug resistance, 2023-08, Vol.22, p.1-8

2023

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Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress

PloS one, 2013-03, Vol.8 (3), p.e58933

2013

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Roseoflavin, a Natural Riboflavin Analogue, Possesses In Vitro and In Vivo Antiplasmodial Activity

Antimicrobial agents and chemotherapy, 2022-10, Vol.66 (10), p.e0054022-e0054022

2022

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verapamil-sensitive chloroquine-associated H⁺ leak from the digestive vacuole in chloroquine-resistant malaria parasites

Journal of cell science, 2008-05, Vol.121 (10), p.1624-1632

2008

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The inhibitory effect of 2-halo derivatives of D-glucose on glycolysis and on the proliferation of the human malaria parasite Plasmodium falciparum

The Journal of pharmacology and experimental therapeutics, 2008-11, Vol.327 (2), p.511

2008

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Structural Modification of Pantothenamides Counteracts Degradation by Pantetheinase and Improves Antiplasmodial Activity

ACS medicinal chemistry letters, 2013-08, Vol.4 (8), p.784-789

2013

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Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

Parasites & vectors, 2016-11, Vol.9 (1), p.589-589, Article 589

2016

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Antiplasmodial Chalcones Inhibit Sorbitol-Induced Hemolysis of Plasmodium falciparum-Infected Erythrocytes

Antimicrobial Agents and Chemotherapy, 2004-09, Vol.48 (9), p.3241-3245

2004

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A cross-metathesis approach to novel pantothenamide derivatives

Beilstein journal of organic chemistry, 2016-05, Vol.12 (1), p.963-968

2016

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Provitamin B5 (Pantothenol) Inhibits Growth of the Intraerythrocytic Malaria Parasite

Antimicrobial Agents and Chemotherapy, 2005-02, Vol.49 (2), p.632-637

2005

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Analysis of Breath Specimens for Biomarkers of Plasmodium falciparum Infection

The Journal of infectious diseases, 2015-10, Vol.212 (7), p.1120-1128

2015

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Acidification of the Malaria Parasite's Digestive Vacuole by a H+-ATPase and a H+-pyrophosphatase

The Journal of biological chemistry, 2003-02, Vol.278 (8), p.5605-5612

2003

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Mutation of the Plasmodium falciparum Flavokinase Confers Resistance to Roseoflavin and 8-Aminoriboflavin

ACS infectious diseases, 2024-06

2024

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Exploring Heteroaromatic Rings as a Replacement for the Labile Amide of Antiplasmodial Pantothenamides

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4478-4497

2021

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Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency

Antimicrobial agents and chemotherapy, 2016-12, Vol.60 (12), p.7146-7152

2016

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A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites

A novel heteromeric pantothenate kinase complex in apicomplexan parasites

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated

Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides

Correction: A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides

The Human Malaria Parasite Plasmodium falciparum Is Not Dependent on Host Coenzyme A Biosynthesis

Coenzyme A biosynthesis: an antimicrobial drug target

Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target

Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress

Roseoflavin, a Natural Riboflavin Analogue, Possesses In Vitro and In Vivo Antiplasmodial Activity

The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides

verapamil-sensitive chloroquine-associated H⁺ leak from the digestive vacuole in chloroquine-resistant malaria parasites

The inhibitory effect of 2-halo derivatives of D-glucose on glycolysis and on the proliferation of the human malaria parasite Plasmodium falciparum

Structural Modification of Pantothenamides Counteracts Degradation by Pantetheinase and Improves Antiplasmodial Activity

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

Antiplasmodial Chalcones Inhibit Sorbitol-Induced Hemolysis of Plasmodium falciparum-Infected Erythrocytes

A cross-metathesis approach to novel pantothenamide derivatives

Provitamin B5 (Pantothenol) Inhibits Growth of the Intraerythrocytic Malaria Parasite

Analysis of Breath Specimens for Biomarkers of Plasmodium falciparum Infection

Acidification of the Malaria Parasite's Digestive Vacuole by a H+-ATPase and a H+-pyrophosphatase

Mutation of the Plasmodium falciparum Flavokinase Confers Resistance to Roseoflavin and 8-Aminoriboflavin

Exploring Heteroaromatic Rings as a Replacement for the Labile Amide of Antiplasmodial Pantothenamides

Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency

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