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Management of the Metabolic Syndrome and Type 2 Diabetes Through Lifestyle Modification

Annual review of nutrition, 2009-01, Vol.29 (1), p.223-256

2009

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The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

The Journal of clinical investigation, 2003-05, Vol.111 (9), p.1409-1421

2003

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Noninvasive predictors of clinically significant portal hypertension in NASH cirrhosis: Validation of ANTICIPATE models and development of a lab‐based model

Hepatology communications, 2022-12, Vol.6 (12), p.3324-3334

2022

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The clinical approach to the detection of lipodystrophy - an AACE consensus statement

Endocrine practice, 2013-01, Vol.19 (1), p.107-116

2013

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Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (22), p.8481-8486

2006

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Clinical effects of long-term metreleptin treatment in patients with lipodystrophy

Endocrine practice, 2011-11, Vol.17 (6), p.922-932

2011

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Crinecerfont Lowers Elevated Hormone Markers in Adults With 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia

The journal of clinical endocrinology and metabolism, 2022-02, Vol.107 (3), p.801-812

2022

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Crinecerfont, a CRF1 Receptor Antagonist, Lowers Adrenal Androgens in Adolescents With Congenital Adrenal Hyperplasia

The journal of clinical endocrinology and metabolism, 2023-10, Vol.108 (11), p.2871-2878

2023

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Recombinant Human Leptin in Women with Hypothalamic Amenorrhea

The New England journal of medicine, 2004-09, Vol.351 (10), p.987-997

2004

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Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia

The New England journal of medicine, 2024-08, Vol.391 (6), p.504-514

2024

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Phase 3 Trial of Crinecerfont in Pediatric Congenital Adrenal Hyperplasia

The New England journal of medicine, 2024-08, Vol.391 (6), p.493-503

2024

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Circulating Resistin Levels Are Not Associated with Obesity or Insulin Resistance in Humans and Are Not Regulated by Fasting or Leptin Administration: Cross-Sectional and Interventional Studies in Normal, Insulin-Resistant, and Diabetic Subjects

The journal of clinical endocrinology and metabolism, 2003-10, Vol.88 (10), p.4848-4856

2003

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Serum Adiponectin Levels Are Inversely Associated with Overall and Central Fat Distribution but Are Not Directly Regulated by Acute Fasting or Leptin Administration in Humans: Cross-Sectional and Interventional Studies

The journal of clinical endocrinology and metabolism, 2003-10, Vol.88 (10), p.4823-4831

2003

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Recombinant Methionyl Human Leptin Therapy in Replacement Doses Improves Insulin Resistance and Metabolic Profile in Patients with Lipoatrophy and Metabolic Syndrome Induced by the Highly Active Antiretroviral Therapy

The journal of clinical endocrinology and metabolism, 2006-07, Vol.91 (7), p.2605-2611

2006

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Lymphoma in acquired generalized lipodystrophy

Leukemia & lymphoma, 2016-01, Vol.57 (1), p.45-50

2016

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Clinical classification and treatment of congenital and acquired lipodystrophy

Endocrine practice, 2010-03, Vol.16 (2), p.310-323

2010

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Diurnal and Ultradian Dynamics of Serum Adiponectin in Healthy Men: Comparison with Leptin, Circulating Soluble Leptin Receptor, and Cortisol Patterns

The journal of clinical endocrinology and metabolism, 2003-06, Vol.88 (6), p.2838-2843

2003

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Rationale for leptin-replacement therapy for severe lipodystrophy

Endocrine practice, 2010-03, Vol.16 (2), p.324-333

2010

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Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: Observational and interventional studies in humans

Diabetes (New York, N.Y.), 2002-07, Vol.51 (7), p.2105-2112

2002

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Leptin Does Not Mediate Short-Term Fasting-Induced Changes in Growth Hormone Pulsatility but Increases IGF-I in Leptin Deficiency States

The journal of clinical endocrinology and metabolism, 2008-07, Vol.93 (7), p.2819-2827

2008

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Ghrelin Levels Are Not Regulated by Recombinant Leptin Administration and/or Three Days of Fasting in Healthy Subjects

The journal of clinical endocrinology and metabolism, 2004-01, Vol.89 (1), p.335-343

2004

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Pharmacokinetics of Subcutaneous Recombinant Methionyl Human Leptin Administration in Healthy Subjects in the Fed and Fasting States: Regulation by Gender and Adiposity

Clinical pharmacokinetics, 2008-01, Vol.47 (11), p.753-764

2008

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It Takes Two to Tango: Combined Amylin/Leptin Agonism as a Potential Approach to Obesity Drug Development

Journal of investigative medicine, 2009-10, Vol.57 (7), p.777-783

2009

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Pharmacokinetics of Recombinant Methionyl Human Leptin after Subcutaneous Administration: Variation of Concentration-Dependent Parameters According to Assay

The journal of clinical endocrinology and metabolism, 2007-06, Vol.92 (6), p.2307-2311

2007

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Pharmacological Management of Type 2 Diabetes Mellitus: Rationale for Rational Use of Insulin

Mayo Clinic proceedings, 2003-04, Vol.78 (4), p.459-467

2003

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Management of the Metabolic Syndrome and Type 2 Diabetes Through Lifestyle Modification

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

Noninvasive predictors of clinically significant portal hypertension in NASH cirrhosis: Validation of ANTICIPATE models and development of a lab‐based model

The clinical approach to the detection of lipodystrophy - an AACE consensus statement

Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans

Clinical effects of long-term metreleptin treatment in patients with lipodystrophy

Crinecerfont Lowers Elevated Hormone Markers in Adults With 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia

Crinecerfont, a CRF1 Receptor Antagonist, Lowers Adrenal Androgens in Adolescents With Congenital Adrenal Hyperplasia

Recombinant Human Leptin in Women with Hypothalamic Amenorrhea

Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia

Phase 3 Trial of Crinecerfont in Pediatric Congenital Adrenal Hyperplasia

Circulating Resistin Levels Are Not Associated with Obesity or Insulin Resistance in Humans and Are Not Regulated by Fasting or Leptin Administration: Cross-Sectional and Interventional Studies in Normal, Insulin-Resistant, and Diabetic Subjects

Serum Adiponectin Levels Are Inversely Associated with Overall and Central Fat Distribution but Are Not Directly Regulated by Acute Fasting or Leptin Administration in Humans: Cross-Sectional and Interventional Studies

Recombinant Methionyl Human Leptin Therapy in Replacement Doses Improves Insulin Resistance and Metabolic Profile in Patients with Lipoatrophy and Metabolic Syndrome Induced by the Highly Active Antiretroviral Therapy

Lymphoma in acquired generalized lipodystrophy

Clinical classification and treatment of congenital and acquired lipodystrophy

Diurnal and Ultradian Dynamics of Serum Adiponectin in Healthy Men: Comparison with Leptin, Circulating Soluble Leptin Receptor, and Cortisol Patterns

Rationale for leptin-replacement therapy for severe lipodystrophy

Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: Observational and interventional studies in humans

Leptin Does Not Mediate Short-Term Fasting-Induced Changes in Growth Hormone Pulsatility but Increases IGF-I in Leptin Deficiency States

Ghrelin Levels Are Not Regulated by Recombinant Leptin Administration and/or Three Days of Fasting in Healthy Subjects

Pharmacokinetics of Subcutaneous Recombinant Methionyl Human Leptin Administration in Healthy Subjects in the Fed and Fasting States: Regulation by Gender and Adiposity

It Takes Two to Tango: Combined Amylin/Leptin Agonism as a Potential Approach to Obesity Drug Development

Pharmacokinetics of Recombinant Methionyl Human Leptin after Subcutaneous Administration: Variation of Concentration-Dependent Parameters According to Assay

Pharmacological Management of Type 2 Diabetes Mellitus: Rationale for Rational Use of Insulin

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