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CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

Immunity (Cambridge, Mass.), 2018-10, Vol.49 (4), p.678-694.e5

2018

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Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection

Nature immunology, 2013-06, Vol.14 (6), p.574-583

2013

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The Transcription Factor TCF1 Preserves the Effector Function of Exhausted CD8 T Cells During Chronic Viral Infection

Frontiers in immunology, 2019-02, Vol.10, p.169-169

2019

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Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6332), p.1423-1427

2017

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The epigenetic landscape of T cell exhaustion

Science (American Association for the Advancement of Science), 2016-12, Vol.354 (6316), p.1165-1169

2016

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Resolution of a chronic viral infection after interleukin-10 receptor blockade

The Journal of experimental medicine, 2006-10, Vol.203 (11), p.2461-2472

2006

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Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection

Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (10), p.5420-5429

2020

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Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells

The Journal of experimental medicine, 2015-07, Vol.212 (8), p.1153-1169

2015

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Adoptive B cell therapy for chronic viral infection

Frontiers in immunology, 2022-07, Vol.13, p.908707-908707

2022

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T-cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents hemophagocytic lymphohistiocytosis manifestations

Journal of allergy and clinical immunology, 2018-09, Vol.142 (3), p.904-913.e3

2018

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PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection

Frontiers in immunology, 2021-07, Vol.12, p.677824-677824

2021

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CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions

Annual review of medicine, 2018-01, Vol.69 (1), p.301-318

2018

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Dynamic CD4 + T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection

Nature immunology, 2021-12, Vol.22 (12), p.1524-1537

2021

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Anti-PD-L1 Immunotherapy of Chronic Virus Infection Improves Virus Control without Augmenting Tissue Damage by Fibrosis

Viruses, 2024-05, Vol.16 (5), p.799

2024

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PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

Nature (London), 2022-10, Vol.610 (7930), p.173-181

2022

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Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV), thereby circumventing LCMV-induced downregulation of costimulatory GITR ligand on APC

The Journal of immunology (1950), 2014-11, Vol.193 (10), p.5033-5043

2014

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Platinum-Based Chemotherapy Attenuates the Effector Response of CD8 T Cells to Concomitant PD-1 Blockade

Clinical cancer research, 2024-05, Vol.30 (9), p.1833-1845

2024

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Lymphocytic choriomeningitis virus meningoencephalitis in a renal transplant recipient following exposure to mice

Transplant infectious disease, 2018-12, Vol.20 (6), p.e13013-n/a

2018

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PD-L1 Checkpoint Inhibition Narrows the Antigen-Specific T Cell Receptor Repertoire in Chronic Lymphocytic Choriomeningitis Virus Infection

Journal of virology, 2020-08, Vol.94 (18)

2020

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Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries

Viruses, 2019-01, Vol.11 (2), p.106

Abdel-Hakeem, Mohamed S

2019

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Low CD8 T-Cell Proliferative Potential and High Viral Load Limit the Effectiveness of Therapeutic Vaccination

Journal of Virology, 2005-07, Vol.79 (14), p.8960-8968

2005

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Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

Nature medicine, 2003-05, Vol.9 (5), p.540-547

2003

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Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses

PLoS pathogens, 2020-10, Vol.16 (10), p.e1008461

2020

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Immune-mediated viral clearance from the CNS without collateral damage

The Journal of experimental medicine, 2015-07, Vol.212 (8), p.1141-1142

2015

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Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo

Nature chemical biology, 2018-12, Vol.14 (12), p.1099-1108

2018

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CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection

The Transcription Factor TCF1 Preserves the Effector Function of Exhausted CD8 T Cells During Chronic Viral Infection

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

The epigenetic landscape of T cell exhaustion

Resolution of a chronic viral infection after interleukin-10 receptor blockade

Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection

Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells

Adoptive B cell therapy for chronic viral infection

T-cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents hemophagocytic lymphohistiocytosis manifestations

PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection

CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions

Dynamic CD4 + T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection

Anti-PD-L1 Immunotherapy of Chronic Virus Infection Improves Virus Control without Augmenting Tissue Damage by Fibrosis

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV), thereby circumventing LCMV-induced downregulation of costimulatory GITR ligand on APC

Platinum-Based Chemotherapy Attenuates the Effector Response of CD8 T Cells to Concomitant PD-1 Blockade

Lymphocytic choriomeningitis virus meningoencephalitis in a renal transplant recipient following exposure to mice

PD-L1 Checkpoint Inhibition Narrows the Antigen-Specific T Cell Receptor Repertoire in Chronic Lymphocytic Choriomeningitis Virus Infection

Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries

Low CD8 T-Cell Proliferative Potential and High Viral Load Limit the Effectiveness of Therapeutic Vaccination

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses

Immune-mediated viral clearance from the CNS without collateral damage

Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo

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