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Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers

Pharmaceutical research, 2022-04, Vol.39 (4), p.653-667

2022

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Sensitive determination of oseltamivir and oseltamivir carboxylate in plasma, urine, cerebrospinal fluid and brain by liquid chromatography–tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-12, Vol.876 (1), p.129-136

2008

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Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling

Clinical and translational science, 2023-06, Vol.16 (6), p.1085-1096

2023

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Determination of Ganciclovir and its prodrug Valganciclovir by hydrophilic interaction liquid chromatography–tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011-02, Vol.879 (5), p.436-442

2011

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Bioanalytics and pharmacokinetics of the nociceptin/orphanin FQ peptide receptor agonist RO0646198 in Wistar rats and Cynomolgus monkeys

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010-08, Vol.878 (23), p.2101-2105

2010

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Determination of carnitine and acylcarnitines in biological samples by capillary electrophoresis–mass spectrometry

Journal of chromatography. Biomedical applications, 1999-12, Vol.735 (2), p.171-188

1999

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High-Throughput Bioanalytical LC/MS/MS Determination of Benzodiazepines in Human Urine: 1000 Samples per 12 Hours

Analytical chemistry (Washington), 1999-07, Vol.71 (13), p.2294-2300

1999

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Model‐Based Drug–Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy

Clinical pharmacology and therapeutics, 2021-12, Vol.110 (6), p.1547-1557

2021

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Determination of Taspoglutide in Human and Animal Plasma Using Liquid Chromatography−Tandem Mass Spectrometry with Orthogonal Column-Switching

Analytical chemistry (Washington), 2009-05, Vol.81 (10), p.3705-3713

2009

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Atmospheric pressure ionization time-of-flight mass spectrometry coupled with fast liquid chromatography for quantitation and accurate mass measurement of five pharmaceutical drugs in human plasma

Journal of mass spectrometry., 2000-03, Vol.35 (3), p.423-431

2000

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A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

British journal of clinical pharmacology, 2019-01, Vol.85 (1), p.181-193

2019

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Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children

Clinical pharmacokinetics, 2023-06, Vol.62 (6), p.891-904

2023

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Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species

Journal of pharmacological and toxicological methods, 2022-05, Vol.115, p.107167-107167, Article 107167

2022

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Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

Pharmacology research & perspectives, 2018-12, Vol.6 (6), p.e00447-n/a

2018

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Effect of mild or moderate hepatic impairment on the pharmacokinetics of risdiplam

British journal of clinical pharmacology, 2022-08, Vol.88 (8), p.3749-3759

2022

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Separation of Nonionic Surfactants by Capillary Electrophoresis and High-Performance Liquid Chromatography

Analytical chemistry (Washington), 1998-05, Vol.70 (9), p.1885-1892

1998

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Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Drug metabolism and disposition, 2022-01, Vol.50 (1), p.65-75

2022

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Bioanalysis of therapeutic peptides: Differentiating between total and anti-drug antibody bound drug using liquid chromatography–tandem mass spectrometry quantitation

Journal of Chromatography A, 2013-11, Vol.1316, p.69-77

2013

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The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy

Neuromuscular disorders : NMD, 2019-01, Vol.29 (1), p.21-29

2019

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Fast liquid chromatographic-tandem mass spectrometric (LC–MS–MS) determination of metformin in plasma samples

Journal of pharmaceutical and biomedical analysis, 2004-03, Vol.34 (5), p.1005-1011

2004

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An improved LC-MS/MS method for the determination of taspoglutide in plasma and urine using orthogonal HILIC-RP column switching, ultra-performance LC separation and 'wrong-way-round' electrospray ionization

Biomedical chromatography, 2011-11, Vol.25 (11), p.1215-1221

2011

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Determination of Glucocorticoids in Animal Plasma, Urine and Tissues by Column-Switching LC-Tandem-MS

Chromatographia, 2008-11, Vol.68 (9-10), p.689-700

2008

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Small Molecule Specific Run Acceptance, Specific Assay Operation, and Chromatographic Run Quality Assessment: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Teams

The AAPS journal, 2014-09, Vol.16 (5), p.885-893

2014

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Determination of dalcetrapib by liquid chromatography–tandem mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2012-07, Vol.66, p.314-324

2012

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Bioanalytics and pharmacokinetics of the nociceptin/orphanin FQ peptide receptor agonist R00646198 in Wistar rats and Cynomolgus monkeys

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Vol.878 (23), p.2101-2105

2010

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Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers

Sensitive determination of oseltamivir and oseltamivir carboxylate in plasma, urine, cerebrospinal fluid and brain by liquid chromatography–tandem mass spectrometry

Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling

Determination of Ganciclovir and its prodrug Valganciclovir by hydrophilic interaction liquid chromatography–tandem mass spectrometry

Bioanalytics and pharmacokinetics of the nociceptin/orphanin FQ peptide receptor agonist RO0646198 in Wistar rats and Cynomolgus monkeys

Determination of carnitine and acylcarnitines in biological samples by capillary electrophoresis–mass spectrometry

High-Throughput Bioanalytical LC/MS/MS Determination of Benzodiazepines in Human Urine: 1000 Samples per 12 Hours

Model‐Based Drug–Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy

Determination of Taspoglutide in Human and Animal Plasma Using Liquid Chromatography−Tandem Mass Spectrometry with Orthogonal Column-Switching

Atmospheric pressure ionization time-of-flight mass spectrometry coupled with fast liquid chromatography for quantitation and accurate mass measurement of five pharmaceutical drugs in human plasma

A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children

Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species

Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

Effect of mild or moderate hepatic impairment on the pharmacokinetics of risdiplam

Separation of Nonionic Surfactants by Capillary Electrophoresis and High-Performance Liquid Chromatography

Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Bioanalysis of therapeutic peptides: Differentiating between total and anti-drug antibody bound drug using liquid chromatography–tandem mass spectrometry quantitation

The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy

Fast liquid chromatographic-tandem mass spectrometric (LC–MS–MS) determination of metformin in plasma samples

An improved LC-MS/MS method for the determination of taspoglutide in plasma and urine using orthogonal HILIC-RP column switching, ultra-performance LC separation and 'wrong-way-round' electrospray ionization

Determination of Glucocorticoids in Animal Plasma, Urine and Tissues by Column-Switching LC-Tandem-MS

Small Molecule Specific Run Acceptance, Specific Assay Operation, and Chromatographic Run Quality Assessment: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Teams

Determination of dalcetrapib by liquid chromatography–tandem mass spectrometry

Bioanalytics and pharmacokinetics of the nociceptin/orphanin FQ peptide receptor agonist R00646198 in Wistar rats and Cynomolgus monkeys

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