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Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers

Pharmaceutical research, 2022-04, Vol.39 (4), p.653-667

2022

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Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling

Clinical and translational science, 2023-06, Vol.16 (6), p.1085-1096

2023

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Bioanalysis of alectinib and metabolite M4 in human plasma, cross-validation and impact on PK assessment

Bioanalysis, 2016-07, Vol.8 (14), p.1465-1479

2016

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Determination of mycophenolic acid and its phenyl glucuronide in human plasma, ultrafiltrate, blood, DBS and dried plasma spots

Bioanalysis, 2010-08, Vol.2 (8), p.1423-1435

2010

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Determination of oseltamivir (Tamiflu®) and oseltamivir carboxylate in dried blood spots using offline or online extraction

Bioanalysis, 2011-02, Vol.3 (4), p.421-437

2011

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Determination of carnitine and acylcarnitines in biological samples by capillary electrophoresis–mass spectrometry

Journal of chromatography. B, Biomedical sciences and applications, 1999-12, Vol.735 (2), p.171-188

1999

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Model‐Based Drug–Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy

Clinical pharmacology and therapeutics, 2021-12, Vol.110 (6), p.1547-1557

2021

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Determination of Taspoglutide in Human and Animal Plasma Using Liquid Chromatography−Tandem Mass Spectrometry with Orthogonal Column-Switching

Analytical chemistry (Washington), 2009-05, Vol.81 (10), p.3705-3713

2009

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A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

British journal of clinical pharmacology, 2019-01, Vol.85 (1), p.181-193

2019

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Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children

Clinical pharmacokinetics, 2023-06, Vol.62 (6), p.891-904

2023

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Bioanalytical aspects and challenges in supporting pediatric drug development

Bioanalysis, 2020-11, Vol.12 (21), p.1505-1508

2020

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Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey

Xenobiotica, 2011-05, Vol.41 (5), p.430-436

2011

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Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species

Journal of pharmacological and toxicological methods, 2022-05, Vol.115, p.107167-107167, Article 107167

2022

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Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

Pharmacology research & perspectives, 2018-12, Vol.6 (6), p.e00447-n/a

2018

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Effect of mild or moderate hepatic impairment on the pharmacokinetics of risdiplam

British journal of clinical pharmacology, 2022-08, Vol.88 (8), p.3749-3759

2022

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Inconsistent internal standard response in LC–MS/MS bioanalysis: an evaluation of case studies

Bioanalysis, 2019-09, Vol.11 (18), p.1657-1667

2019

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Separation of ionic and neutral surfactants by capillary electrophoresis and high-performance liquid chromatography

Journal of Chromatography A, 1996-09, Vol.745 (1), p.281-292

1996

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Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Drug metabolism and disposition, 2022-01, Vol.50 (1), p.65-75

2022

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Separation of Nonionic Surfactants by Capillary Electrophoresis and High-Performance Liquid Chromatography

Analytical chemistry (Washington), 1998-05, Vol.70 (9), p.1885-1892

1998

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Massenspektrometrische identifizierung und charakterisierung von posttranslationalen modifikationen bei pathologischen freien antikörperleichtketten

Heinig, Katja

2015

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Ocular bioanalysis: challenges and advancements in recent years for these rare matrices

Bioanalysis, 2017-12, Vol.9 (24), p.1997-2014

2017

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Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects

Xenobiotica, 2017-03, Vol.47 (3), p.217-229

2017

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The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy

Neuromuscular disorders : NMD, 2019-01, Vol.29 (1), p.21-29

2019

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What are the challenges of stability investigations and sample stabilization in regulated bioanalysis?

Bioanalysis, 2013-08, Vol.5 (15), p.1811-1814

2013

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LC-MS/MS determination of alectinib and its major human metabolite M4 in human urine: prevention of nonspecific binding

Bioanalysis, 2017-03, Vol.9 (5), p.459-468

2017

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Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers

Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling

Bioanalysis of alectinib and metabolite M4 in human plasma, cross-validation and impact on PK assessment

Determination of mycophenolic acid and its phenyl glucuronide in human plasma, ultrafiltrate, blood, DBS and dried plasma spots

Determination of oseltamivir (Tamiflu®) and oseltamivir carboxylate in dried blood spots using offline or online extraction

Determination of carnitine and acylcarnitines in biological samples by capillary electrophoresis–mass spectrometry

Model‐Based Drug–Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy

Determination of Taspoglutide in Human and Animal Plasma Using Liquid Chromatography−Tandem Mass Spectrometry with Orthogonal Column-Switching

A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children

Bioanalytical aspects and challenges in supporting pediatric drug development

Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey

Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species

Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

Effect of mild or moderate hepatic impairment on the pharmacokinetics of risdiplam

Inconsistent internal standard response in LC–MS/MS bioanalysis: an evaluation of case studies

Separation of ionic and neutral surfactants by capillary electrophoresis and high-performance liquid chromatography

Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Separation of Nonionic Surfactants by Capillary Electrophoresis and High-Performance Liquid Chromatography

Massenspektrometrische identifizierung und charakterisierung von posttranslationalen modifikationen bei pathologischen freien antikörperleichtketten

Ocular bioanalysis: challenges and advancements in recent years for these rare matrices

Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects

The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy

What are the challenges of stability investigations and sample stabilization in regulated bioanalysis?

LC-MS/MS determination of alectinib and its major human metabolite M4 in human urine: prevention of nonspecific binding

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