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Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers

Pharmaceutical research, 2022-04, Vol.39 (4), p.653-667

2022

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Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling

Clinical and translational science, 2023-06, Vol.16 (6), p.1085-1096

2023

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Model‐Based Drug–Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy

Clinical pharmacology and therapeutics, 2021-12, Vol.110 (6), p.1547-1557

2021

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High-Throughput Bioanalytical LC/MS/MS Determination of Benzodiazepines in Human Urine: 1000 Samples per 12 Hours

Analytical chemistry (Washington), 1999-07, Vol.71 (13), p.2294-2300

1999

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Determination of Taspoglutide in Human and Animal Plasma Using Liquid Chromatography−Tandem Mass Spectrometry with Orthogonal Column-Switching

Analytical chemistry (Washington), 2009-05, Vol.81 (10), p.3705-3713

2009

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A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

British journal of clinical pharmacology, 2019-01, Vol.85 (1), p.181-193

2019

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Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children

Clinical pharmacokinetics, 2023-06, Vol.62 (6), p.891-904

2023

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Bioanalytical aspects and challenges in supporting pediatric drug development

Bioanalysis, 2020-11, Vol.12 (21), p.1505-1508

2020

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Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey

Xenobiotica, 2011-05, Vol.41 (5), p.430-436

2011

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Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species

Journal of pharmacological and toxicological methods, 2022-05, Vol.115, p.107167-107167, Article 107167

2022

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Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

Pharmacology research & perspectives, 2018-12, Vol.6 (6), p.e00447-n/a

2018

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Effect of mild or moderate hepatic impairment on the pharmacokinetics of risdiplam

British journal of clinical pharmacology, 2022-08, Vol.88 (8), p.3749-3759

2022

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Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Drug metabolism and disposition, 2022-01, Vol.50 (1), p.65-75

2022

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Separation of Nonionic Surfactants by Capillary Electrophoresis and High-Performance Liquid Chromatography

Analytical chemistry (Washington), 1998-05, Vol.70 (9), p.1885-1892

1998

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Relationship Between Central and Peripheral SMN Protein Increase Upon Treatment with RO7034067 (RG7916) (S46.007)

Neurology, 2018-04, Vol.90 (15_supplement)

2018

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Massenspektrometrische identifizierung und charakterisierung von posttranslationalen modifikationen bei pathologischen freien antikörperleichtketten

Heinig, Katja

2015

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Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects

Xenobiotica, 2017-03, Vol.47 (3), p.217-229

2017

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The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy

Neuromuscular disorders : NMD, 2019-01, Vol.29 (1), p.21-29

2019

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Fast liquid chromatographic-tandem mass spectrometric (LC–MS–MS) determination of metformin in plasma samples

Journal of pharmaceutical and biomedical analysis, 2004-03, Vol.34 (5), p.1005-1011

2004

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Determination of dalcetrapib by liquid chromatography–tandem mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2012-07, Vol.66, p.314-324

2012

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Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies

Drug metabolism and disposition, 2012-08, Vol.40 (8), p.1556-1565

2012

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Bioanalytics and pharmacokinetics of the nociceptin/orphanin FQ peptide receptor agonist R00646198 in Wistar rats and Cynomolgus monkeys

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Vol.878 (23), p.2101-2105

2010

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Determination of cationic surfactants by capillary electrophoresis

Fresenius' journal of analytical chemistry, 1997-06, Vol.358 (4), p.500-505

1997

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Determination of Triton X-100 in influenza vaccine by high-performance liquid chromatography and capillary electrophoresis

Fresenius' journal of analytical chemistry, 1997-09, Vol.359 (2), p.202-206

1997

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Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers

Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling

Model‐Based Drug–Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy

High-Throughput Bioanalytical LC/MS/MS Determination of Benzodiazepines in Human Urine: 1000 Samples per 12 Hours

Determination of Taspoglutide in Human and Animal Plasma Using Liquid Chromatography−Tandem Mass Spectrometry with Orthogonal Column-Switching

A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children

Bioanalytical aspects and challenges in supporting pediatric drug development

Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey

Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species

Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

Effect of mild or moderate hepatic impairment on the pharmacokinetics of risdiplam

Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Separation of Nonionic Surfactants by Capillary Electrophoresis and High-Performance Liquid Chromatography

Relationship Between Central and Peripheral SMN Protein Increase Upon Treatment with RO7034067 (RG7916) (S46.007)

Massenspektrometrische identifizierung und charakterisierung von posttranslationalen modifikationen bei pathologischen freien antikörperleichtketten

Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects

The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy

Fast liquid chromatographic-tandem mass spectrometric (LC–MS–MS) determination of metformin in plasma samples

Small Molecule Specific Run Acceptance, Specific Assay Operation, and Chromatographic Run Quality Assessment: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Teams

Determination of dalcetrapib by liquid chromatography–tandem mass spectrometry

Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies

Bioanalytics and pharmacokinetics of the nociceptin/orphanin FQ peptide receptor agonist R00646198 in Wistar rats and Cynomolgus monkeys

Determination of cationic surfactants by capillary electrophoresis

Determination of Triton X-100 in influenza vaccine by high-performance liquid chromatography and capillary electrophoresis

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