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Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers

Pharmaceutical research, 2022-04, Vol.39 (4), p.653-667

2022

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Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling

Clinical and translational science, 2023-06, Vol.16 (6), p.1085-1096

2023

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Bioanalysis of alectinib and metabolite M4 in human plasma, cross-validation and impact on PK assessment

Bioanalysis, 2016-07, Vol.8 (14), p.1465-1479

2016

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Determination of mycophenolic acid and its phenyl glucuronide in human plasma, ultrafiltrate, blood, DBS and dried plasma spots

Bioanalysis, 2010-08, Vol.2 (8), p.1423-1435

2010

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Determination of oseltamivir (Tamiflu®) and oseltamivir carboxylate in dried blood spots using offline or online extraction

Bioanalysis, 2011-02, Vol.3 (4), p.421-437

2011

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Model‐Based Drug–Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy

Clinical pharmacology and therapeutics, 2021-12, Vol.110 (6), p.1547-1557

2021

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High-Throughput Bioanalytical LC/MS/MS Determination of Benzodiazepines in Human Urine: 1000 Samples per 12 Hours

Analytical chemistry (Washington), 1999-07, Vol.71 (13), p.2294-2300

1999

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Determination of Taspoglutide in Human and Animal Plasma Using Liquid Chromatography−Tandem Mass Spectrometry with Orthogonal Column-Switching

Analytical chemistry (Washington), 2009-05, Vol.81 (10), p.3705-3713

2009

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Atmospheric pressure ionization time-of-flight mass spectrometry coupled with fast liquid chromatography for quantitation and accurate mass measurement of five pharmaceutical drugs in human plasma

Journal of mass spectrometry., 2000-03, Vol.35 (3), p.423-431

2000

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A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

British journal of clinical pharmacology, 2019-01, Vol.85 (1), p.181-193

2019

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Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children

Clinical pharmacokinetics, 2023-06, Vol.62 (6), p.891-904

2023

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Bioanalytical aspects and challenges in supporting pediatric drug development

Bioanalysis, 2020-11, Vol.12 (21), p.1505-1508

2020

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Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey

Xenobiotica, 2011-05, Vol.41 (5), p.430-436

2011

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Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species

Journal of pharmacological and toxicological methods, 2022-05, Vol.115, p.107167-107167, Article 107167

2022

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Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

Pharmacology research & perspectives, 2018-12, Vol.6 (6), p.e00447-n/a

2018

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Effect of mild or moderate hepatic impairment on the pharmacokinetics of risdiplam

British journal of clinical pharmacology, 2022-08, Vol.88 (8), p.3749-3759

2022

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Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Drug metabolism and disposition, 2022-01, Vol.50 (1), p.65-75

2022

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Inconsistent internal standard response in LC–MS/MS bioanalysis: an evaluation of case studies

Bioanalysis, 2019-09, Vol.11 (18), p.1657-1667

2019

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Separation of ionic and neutral surfactants by capillary electrophoresis and high-performance liquid chromatography

Journal of Chromatography A, 1996-09, Vol.745 (1), p.281-292

1996

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Separation of Nonionic Surfactants by Capillary Electrophoresis and High-Performance Liquid Chromatography

Analytical chemistry (Washington), 1998-05, Vol.70 (9), p.1885-1892

1998

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Relationship Between Central and Peripheral SMN Protein Increase Upon Treatment with RO7034067 (RG7916) (S46.007)

Neurology, 2018-04, Vol.90 (15_supplement)

2018

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Massenspektrometrische identifizierung und charakterisierung von posttranslationalen modifikationen bei pathologischen freien antikörperleichtketten

Heinig, Katja

2015

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Ocular bioanalysis: challenges and advancements in recent years for these rare matrices

Bioanalysis, 2017-12, Vol.9 (24), p.1997-2014

2017

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Bioanalysis of therapeutic peptides: Differentiating between total and anti-drug antibody bound drug using liquid chromatography–tandem mass spectrometry quantitation

Journal of Chromatography A, 2013-11, Vol.1316, p.69-77

2013

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Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects

Xenobiotica, 2017-03, Vol.47 (3), p.217-229

2017

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Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers

Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling

Bioanalysis of alectinib and metabolite M4 in human plasma, cross-validation and impact on PK assessment

Determination of mycophenolic acid and its phenyl glucuronide in human plasma, ultrafiltrate, blood, DBS and dried plasma spots

Determination of oseltamivir (Tamiflu®) and oseltamivir carboxylate in dried blood spots using offline or online extraction

Model‐Based Drug–Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy

High-Throughput Bioanalytical LC/MS/MS Determination of Benzodiazepines in Human Urine: 1000 Samples per 12 Hours

Determination of Taspoglutide in Human and Animal Plasma Using Liquid Chromatography−Tandem Mass Spectrometry with Orthogonal Column-Switching

Atmospheric pressure ionization time-of-flight mass spectrometry coupled with fast liquid chromatography for quantitation and accurate mass measurement of five pharmaceutical drugs in human plasma

A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children

Bioanalytical aspects and challenges in supporting pediatric drug development

Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey

Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species

Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

Effect of mild or moderate hepatic impairment on the pharmacokinetics of risdiplam

Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Inconsistent internal standard response in LC–MS/MS bioanalysis: an evaluation of case studies

Separation of ionic and neutral surfactants by capillary electrophoresis and high-performance liquid chromatography

Separation of Nonionic Surfactants by Capillary Electrophoresis and High-Performance Liquid Chromatography

Relationship Between Central and Peripheral SMN Protein Increase Upon Treatment with RO7034067 (RG7916) (S46.007)

Massenspektrometrische identifizierung und charakterisierung von posttranslationalen modifikationen bei pathologischen freien antikörperleichtketten

Ocular bioanalysis: challenges and advancements in recent years for these rare matrices

Bioanalysis of therapeutic peptides: Differentiating between total and anti-drug antibody bound drug using liquid chromatography–tandem mass spectrometry quantitation

Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects

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