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Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors

Journal of medicinal chemistry, 1996-10, Vol.39 (22), p.4349-4353

1996

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Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant: Lead Identification and SAR of 3- and 4-Substituted Derivatives

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.1034-1040

2000

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A Drug Resistance Mutation in the Inhibitor Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impairs DNA Synthesis and RNA Degradation

Biochemistry (Easton), 1996-07, Vol.35 (30), p.9737-9745

1996

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Oxazolidinones: a new class of antibacterials

Current Opinion in Pharmacology, 2001-10, Vol.1 (5), p.470-476

2001

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Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase

Biochemistry (Easton), 1991-03, Vol.30 (10), p.2651-2655

1991

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Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

Journal of medicinal chemistry, 1998-09, Vol.41 (20), p.3793-3803

1998

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Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy

Journal of Virology, 1993-09, Vol.67 (9), p.5353-5359

1993

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The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase

Biochemical pharmacology, 1996-03, Vol.51 (6), p.743-750

1996

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Kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-88204E

Biochemistry (Easton), 1993-07, Vol.32 (26), p.6548-6554

1993

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Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors

Journal of medicinal chemistry, 1996-09, Vol.39 (19), p.3769-3789

1996

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Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E

Biochemical pharmacology, 1994-06, Vol.47 (11), p.2017-2028

1994

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(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes

Journal of Virology, 1996-06, Vol.70 (6), p.3698-3705

1996

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Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2344-2356

1991

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Characterization of the p68/p58 Heterodimer of Human Immunodeficiency Virus Type 2 Reverse Transcriptase

Biochemistry (Easton), 1996-02, Vol.35 (6), p.1911-1917

1996

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Mechanism of resistance to U-90152S and sensitization to L-697,661 by a proline to leucine change at residue 236 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase

FEBS letters, 1995-02, Vol.359 (2), p.233-238

1995

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Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere

Journal of medicinal chemistry, 1993-04, Vol.36 (8), p.941-952

1993

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Simultaneous mutations at Tyr-181 and Tyr-188 in HIV-1 reverse transcriptase prevents inhibition of RNA-dependent DNA polymerase activity by the bisheteroarylpiperazine (BHAP) U-90152s

FEBS letters, 1995-08, Vol.370 (1), p.59-62

1995

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Escherichia coli expression, purification, and biological activity of a truncated soluble CD4

AIDS research and human retroviruses, 1990-04, Vol.6 (4), p.465-479

1990

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Denaturation/refolding of purified recombinant HIV reverse transcriptase yields monomeric enzyme with high enzymatic activity

AIDS research and human retroviruses, 1990-03, Vol.6 (3), p.329-340

1990

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Effects of a soluble CD4 and CD4-Pseudomonas exotoxn A chimeric protein on human peripheral blood lymphocytes : lymphocyte activation and anti-HIV activity in vitro

Antiviral research, 1991, Vol.16 (3), p.267-279

1991

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Expression and characterization of chimeric rDNA proteins engineered for purification and enzymatic cleavage

Protein expression and purification, 1991-04, Vol.2 (2), p.205-213

1991

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Effects of a soluble CD4 and CD4- Pseudomonas exotoxin A chimeric protein on human peripheral blood lymphocytes: Lymphocyte activation and anti-HIV activity in vitro

Antiviral research, 1991-10, Vol.16 (3), p.267-279

1991

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The lack of PDGF-stimulated PGE2 release from ras-transformed NIH-3T3 cells results from reduced phospholipase C but not phospholipase A2 activity

Biochemical and biophysical research communications, 1987-06, Vol.145 (3), p.1254-1259

1987

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Resolution of microheterogeneity associated with recombinant HIV-1 heterodimeric reverse transcriptase

Protein expression and purification, 1992, Vol.3 (2), p.151-159

1992

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Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors

Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant: Lead Identification and SAR of 3- and 4-Substituted Derivatives

A Drug Resistance Mutation in the Inhibitor Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impairs DNA Synthesis and RNA Degradation

Oxazolidinones: a new class of antibacterials

Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase

(−)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor

Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy

The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase

Kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-88204E

Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors

Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E

(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes

Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity

Characterization of the p68/p58 Heterodimer of Human Immunodeficiency Virus Type 2 Reverse Transcriptase

Mechanism of resistance to U-90152S and sensitization to L-697,661 by a proline to leucine change at residue 236 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase

Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere

Simultaneous mutations at Tyr-181 and Tyr-188 in HIV-1 reverse transcriptase prevents inhibition of RNA-dependent DNA polymerase activity by the bisheteroarylpiperazine (BHAP) U-90152s

Escherichia coli expression, purification, and biological activity of a truncated soluble CD4

Denaturation/refolding of purified recombinant HIV reverse transcriptase yields monomeric enzyme with high enzymatic activity

Effects of a soluble CD4 and CD4-Pseudomonas exotoxn A chimeric protein on human peripheral blood lymphocytes : lymphocyte activation and anti-HIV activity in vitro

Expression and characterization of chimeric rDNA proteins engineered for purification and enzymatic cleavage

Effects of a soluble CD4 and CD4- Pseudomonas exotoxin A chimeric protein on human peripheral blood lymphocytes: Lymphocyte activation and anti-HIV activity in vitro

The lack of PDGF-stimulated PGE2 release from ras-transformed NIH-3T3 cells results from reduced phospholipase C but not phospholipase A2 activity

Resolution of microheterogeneity associated with recombinant HIV-1 heterodimeric reverse transcriptase

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