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Role of reactive metabolites in the circulation in extrahepatic toxicity

Expert opinion on drug metabolism & toxicology, 2012-09, Vol.8 (9), p.1157-1172

2012

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L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

The Journal of pharmacology and experimental therapeutics, 2008-09, Vol.326 (3), p.809-817

2008

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Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

The Journal of pharmacology and experimental therapeutics, 2009-06, Vol.329 (3), p.1148-1155

2009

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S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1095-1101

2007

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NREL VI rotor blade: numerical investigation and winglet design and optimization using CFD

Wind energy (Chichester, England), 2014-04, Vol.17 (4), p.605-626

2014

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Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design

Expert opinion on drug discovery, 2018-09, Vol.13 (9), p.815-824

2018

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Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

Expert opinion on drug metabolism & toxicology, 2017-05, Vol.13 (5), p.513-524

2017

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Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity

Toxicology and applied pharmacology, 2009-05, Vol.236 (3), p.358-365

2009

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Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.1163-1172

2003

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Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Chemical research in toxicology, 2004-06, Vol.17 (6), p.819-826

2004

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Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Chemical research in toxicology, 2001-12, Vol.14 (12), p.1590-1595

2001

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Mutagenicity of the cysteine S -conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test

Toxicology (Amsterdam), 2013-04, Vol.306, p.157-161

2013

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Human Liver Microsomes Are Efficient Catalysts of 1,3-Butadiene Oxidation: Evidence for Major Roles by Cytochromes P450 2A6 and 2E1

Archives of biochemistry and biophysics, 1994-06, Vol.311 (2), p.342-349

1994

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In vitro reactions of butadiene monoxide with single- and double-stranded DNA : Characterization and quantitation of several purine and pyrimidine adducts

Carcinogenesis (New York), 1999-02, Vol.20 (2), p.285-292

1999

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Characterization of the Reaction Products of 2‘-Deoxyguanosine and 1,2,3,4-Diepoxybutane after Acid Hydrolysis: Formation of Novel Guanine and Pyrimidine Adducts

Chemical research in toxicology, 2004-04, Vol.17 (4), p.521-528

2004

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Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences

The Journal of pharmacology and experimental therapeutics, 2001-04, Vol.297 (1), p.155

2001

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Alcohol Dehydrogenase- and Rat Liver Cytosol-Dependent Bioactivation of 1‑Chloro-2-hydroxy-3-butene to 1‑Chloro-3-buten-2-one, a Bifunctional Alkylating Agent

Chemical research in toxicology, 2012-11, Vol.25 (11), p.2600-2607

2012

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Identification of a Fused-Ring 2′-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1‑Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene

Chemical research in toxicology, 2016-06, Vol.29 (6), p.1041-1050

2016

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Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats

The Journal of pharmacology and experimental therapeutics, 1999-09, Vol.290 (3), p.950

1999

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Reduction of l-methionine selenoxide to seleno- l-methionine by endogenous thiols, ascorbic acid, or methimazole

Biochemical pharmacology, 2009-01, Vol.77 (1), p.134-140

2009

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Investigations on Blade Tip Tilting for Hawt Rotor Blades Using CFD

International journal of green energy, 2015-02, Vol.12 (2), p.125-138

2015

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Novel adducts from the reaction of 1-chloro-3-buten-2-one with 2′-deoxyguanosine. Structural characterization and potential as tools to investigate 1,3-butadiene carcinogenicity

Chemico-biological interactions, 2015-01, Vol.226, p.40-48

2015

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A Nomenclature for the Mammalian Flavin-Containing Monooxygenase Gene Family Based on Amino Acid Sequence Identities

Archives of biochemistry and biophysics, 1994, Vol.308 (1), p.254-257

1994

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The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance

Expert opinion on drug metabolism & toxicology, 2010-11, Vol.6 (11), p.1333-1346

2010

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Oxidation of butadiene monoxide to meso- and (+/-)-diepoxybutane by cDNA-expressed human cytochrome P450s and by mouse, rat, and human liver microsomes: evidence for preferential hydration of meso-diepoxybutane in rat and human liver microsomes

Archives of biochemistry and biophysics, 1997-01, Vol.337 (2), p.176

1997

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Role of reactive metabolites in the circulation in extrahepatic toxicity

L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

NREL VI rotor blade: numerical investigation and winglet design and optimization using CFD

Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design

Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity

Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells

Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Mutagenicity of the cysteine S -conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test

Human Liver Microsomes Are Efficient Catalysts of 1,3-Butadiene Oxidation: Evidence for Major Roles by Cytochromes P450 2A6 and 2E1

In vitro reactions of butadiene monoxide with single- and double-stranded DNA : Characterization and quantitation of several purine and pyrimidine adducts

Characterization of the Reaction Products of 2‘-Deoxyguanosine and 1,2,3,4-Diepoxybutane after Acid Hydrolysis: Formation of Novel Guanine and Pyrimidine Adducts

Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences

Alcohol Dehydrogenase- and Rat Liver Cytosol-Dependent Bioactivation of 1‑Chloro-2-hydroxy-3-butene to 1‑Chloro-3-buten-2-one, a Bifunctional Alkylating Agent

Identification of a Fused-Ring 2′-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1‑Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene

Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats

Reduction of l-methionine selenoxide to seleno- l-methionine by endogenous thiols, ascorbic acid, or methimazole

Investigations on Blade Tip Tilting for Hawt Rotor Blades Using CFD

Novel adducts from the reaction of 1-chloro-3-buten-2-one with 2′-deoxyguanosine. Structural characterization and potential as tools to investigate 1,3-butadiene carcinogenicity

A Nomenclature for the Mammalian Flavin-Containing Monooxygenase Gene Family Based on Amino Acid Sequence Identities

The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance

Oxidation of butadiene monoxide to meso- and (+/-)-diepoxybutane by cDNA-expressed human cytochrome P450s and by mouse, rat, and human liver microsomes: evidence for preferential hydration of meso-diepoxybutane in rat and human liver microsomes

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