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Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

Frontiers in immunology, 2019-01, Vol.9, p.3037-3037

2019

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Characterization of immunoglobulin heavy chain knockout rats

European journal of immunology, 2010-10, Vol.40 (10), p.2932-2941

2010

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Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice

The Journal of experimental medicine, 2007-12, Vol.204 (13), p.3271-3283

2007

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Expression of a Dromedary Heavy Chain-Only Antibody and B Cell Development in the Mouse

The Journal of immunology (1950), 2005-09, Vol.175 (6), p.3769-3779

2005

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Immunoglobulin aggregation leading to Russell body formation is prevented by the antibody light chain

Blood, 2010-01, Vol.115 (2), p.282-288

2010

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Strategies to Obtain Diverse and Specific Human Monoclonal Antibodies From Transgenic Animals

Transplantation, 2017-08, Vol.101 (8), p.1770

2017

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Light chain-deficient mice produce novel multimeric heavy-chain-only IgA by faulty class switching

International immunology, 2009-08, Vol.21 (8), p.957-966

2009

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Human Antibody Production in Transgenic Animals

Archivum Immunologiae et Therapiae Experimentalis, 2015-04, Vol.63 (2), p.101-108

2015

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Selection of a human anti-progesterone antibody fragment from a transgenic mouse library by ARM ribosome display

Journal of immunological methods, 1999-12, Vol.231 (1), p.105-117

1999

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Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain

The Journal of immunology (1950), 2003-02, Vol.170 (3), p.1354-1361

2003

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High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region

The Journal of immunology (1950), 2013-02, Vol.190 (4), p.1481-1490

2013

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Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain yeast artificial chromosomes

The Journal of immunology (1950), 1999-12, Vol.163 (12), p.6898-6906

1999

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B-cell tumorigenesis in mice carrying a yeast artificial chromosome-based immunoglobulin heavy/c-myc translocus is independent of the heavy chain intron enhancer (Eμ)

Cancer research (Chicago, Ill.), 1999-11, Vol.59 (21), p.5625-5628

1999

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Heavy-chain-only antibody expression and B-cell development in the mouse

Critical Reviews in Immunology, 2006, Vol.26 (5), p.377-390

2006

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Evolution of the rat immunoglobulin gamma heavy-chain gene family

Gene, 1988-12, Vol.74 (2), p.473-482

Brueggemann, M

1988

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High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat C[H] region

The Journal of immunology (1950), 2013-02, Vol.190 (4), p.1481-1490

2013

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Correction: High Affinity IgG Antibodies Develop Naturally in Ig-Knockout Rats Carrying Germline Human IgH/Igκ/Igλ Loci Bearing the Rat CH Region

The Journal of immunology (1950), 2013-06, Vol.190 (12), p.6707-6707

2013

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The two-domain hypothesis in Beckwith–Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster

Human molecular genetics, 2005-02, Vol.14 (4), p.503-511

2005

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Human monoclonal antibodies to HIV-1 gp140 from mice bearing YAC-based human immunoglobulin transloci

Protein engineering, design and selection, 2011-10, Vol.24 (10), p.791-799

2011

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Truncation of the μ heavy chain alters BCR signalling and allows recruitment of CD5+ B cells

International immunology, 2001-12, Vol.13 (12), p.1489-1499

2001

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Removal of the BiP-retention domain in Cmicro permits surface deposition and developmental progression without L-chain

Molecular immunology, 2008-08, Vol.45 (13), p.3573-3579

2008

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Removal of the BiP-retention domain in Cμ permits surface deposition and developmental progression without L-chain

Molecular immunology, 2008-08, Vol.45 (13), p.3573-3579

2008

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Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies

BMC biotechnology, 2017-01, Vol.17 (1), p.3-3, Article 3

2017

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Abstract LB-090: Sequence-based discovery of fully human anti-CD3 and anti-PDL1 single domain antibodies using novel transgenic rats

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.LB-090-LB-090

2016

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Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

Characterization of immunoglobulin heavy chain knockout rats

Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies

Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice

Expression of a Dromedary Heavy Chain-Only Antibody and B Cell Development in the Mouse

Immunoglobulin aggregation leading to Russell body formation is prevented by the antibody light chain

Strategies to Obtain Diverse and Specific Human Monoclonal Antibodies From Transgenic Animals

Light chain-deficient mice produce novel multimeric heavy-chain-only IgA by faulty class switching

Human Antibody Production in Transgenic Animals

Selection of a human anti-progesterone antibody fragment from a transgenic mouse library by ARM ribosome display

Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain

High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region

Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain yeast artificial chromosomes

B-cell tumorigenesis in mice carrying a yeast artificial chromosome-based immunoglobulin heavy/c-myc translocus is independent of the heavy chain intron enhancer (Eμ)

Heavy-chain-only antibody expression and B-cell development in the mouse

Evolution of the rat immunoglobulin gamma heavy-chain gene family

High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat C[H] region

Correction: High Affinity IgG Antibodies Develop Naturally in Ig-Knockout Rats Carrying Germline Human IgH/Igκ/Igλ Loci Bearing the Rat CH Region

The two-domain hypothesis in Beckwith–Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster

Human monoclonal antibodies to HIV-1 gp140 from mice bearing YAC-based human immunoglobulin transloci

Truncation of the μ heavy chain alters BCR signalling and allows recruitment of CD5+ B cells

Removal of the BiP-retention domain in Cmicro permits surface deposition and developmental progression without L-chain

Removal of the BiP-retention domain in Cμ permits surface deposition and developmental progression without L-chain

Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies

Abstract LB-090: Sequence-based discovery of fully human anti-CD3 and anti-PDL1 single domain antibodies using novel transgenic rats

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