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Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids

Archives of toxicology, 2019-08, Vol.93 (8), p.2197-2209

2019

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Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes

Archives of toxicology, 2021-01, Vol.95 (1), p.311-319

2021

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Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype

Archives of toxicology, 2018-02, Vol.92 (2), p.661-668

2018

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Genetic heterogeneity among slow acetylator N-acetyltransferase 2 phenotypes in cryopreserved human hepatocytes

Archives of toxicology, 2017-07, Vol.91 (7), p.2655-2661

2017

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Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens

Archives of toxicology, 2017-09, Vol.91 (9), p.3185-3188

2017

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First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans

Archives of toxicology, 2017-12, Vol.91 (12), p.3913-3925

2017

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Investigations on detoxification mechanisms of novel para-phenylenediamine analogues through N-acetyltransferase 1 (NAT-1)

Archives of toxicology, 2022, Vol.96 (1), p.153-165

2022

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Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations

Archives of toxicology, 2024-08, Vol.98 (8), p.2695-2709

2024

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Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4′-methylenedianiline

Archives of toxicology, 2019-08, Vol.93 (8), p.2237-2246

2019

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Validity of different biomonitoring parameters for the assessment of occupational exposure to N,N-dimethylformamide (DMF)

Archives of toxicology, 2018-07, Vol.92 (7), p.2183-2193

2018

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N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes

Archives of toxicology, 2022-12, Vol.96 (12), p.3257-3263

2022

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Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

Archives of toxicology, 2022-01, Vol.96 (1), p.135-151

2022

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The mixture of “ecstasy” and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations

Archives of toxicology, 2014-02, Vol.88 (2), p.455-473

2014

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Designer drugs: mechanism of action and adverse effects

Archives of toxicology, 2020-04, Vol.94 (4), p.1085-1133

2020

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Toxic effects of A2E in human ARPE-19 cells were prevented by resveratrol: a potential nutritional bioactive for age-related macular degeneration treatment

Archives of toxicology, 2020-02, Vol.94 (2), p.553-572

2020

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Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity

Archives of toxicology, 2015-06, Vol.89 (6), p.883-897

2015

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Catalytic properties and heat stabilities of novel recombinant human N-acetyltransferase 2 allozymes support existence of genetic heterogeneity within the slow acetylator phenotype

Archives of toxicology, 2017-08, Vol.91 (8), p.2827-2835

2017

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The essential role of CYP2E1 in metabolism and hepatotoxicity of N,N-dimethylformamide using a novel Cyp2e1 knockout mouse model and a population study

Archives of toxicology, 2019-11, Vol.93 (11), p.3169-3181

2019

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"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites

Archives of toxicology, 2014-02, Vol.88 (2), p.515-531

2014

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Novel insights into the mechanism of cyclophosphamide-induced bladder toxicity: chloroacetaldehyde’s contribution to urothelial dysfunction in vitro

Archives of toxicology, 2019-11, Vol.93 (11), p.3291-3303

2019

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Light-Emitting Electrochemical Cells: A Review on Recent Progress

Topics in current chemistry (2016), 2016-08, Vol.374 (4), Article 40

2016

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In vitro human cell-based TTR-TRβ CALUX assay indicates thyroid hormone transport disruption of short-chain, medium-chain, and long-chain chlorinated paraffins

Archives of toxicology, 2021-04, Vol.95 (4), p.1391-1396

2021

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Determination of NAT2 acetylation status in the Greenlandic population

Archives of toxicology, 2016-04, Vol.90 (4), p.883-889

2016

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Refinement of the prediction of N-acetyltransferase 2 (NAT2) phenotypes with respect to enzyme activity and urinary bladder cancer risk

Archives of toxicology, 2013-12, Vol.87 (12), p.2129-2139

2013

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The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

Archives of toxicology, 2022-05, Vol.96 (5), p.1297-1352

2022

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Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids

Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes

Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype

Genetic heterogeneity among slow acetylator N-acetyltransferase 2 phenotypes in cryopreserved human hepatocytes

Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens

First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans

Investigations on detoxification mechanisms of novel para-phenylenediamine analogues through N-acetyltransferase 1 (NAT-1)

Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations

Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4′-methylenedianiline

Validity of different biomonitoring parameters for the assessment of occupational exposure to N,N-dimethylformamide (DMF)

N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes

Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

The mixture of “ecstasy” and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations

Designer drugs: mechanism of action and adverse effects

Toxic effects of A2E in human ARPE-19 cells were prevented by resveratrol: a potential nutritional bioactive for age-related macular degeneration treatment

Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity

Catalytic properties and heat stabilities of novel recombinant human N-acetyltransferase 2 allozymes support existence of genetic heterogeneity within the slow acetylator phenotype

The essential role of CYP2E1 in metabolism and hepatotoxicity of N,N-dimethylformamide using a novel Cyp2e1 knockout mouse model and a population study

"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites

Novel insights into the mechanism of cyclophosphamide-induced bladder toxicity: chloroacetaldehyde’s contribution to urothelial dysfunction in vitro

Light-Emitting Electrochemical Cells: A Review on Recent Progress

In vitro human cell-based TTR-TRβ CALUX assay indicates thyroid hormone transport disruption of short-chain, medium-chain, and long-chain chlorinated paraffins

Determination of NAT2 acetylation status in the Greenlandic population

Refinement of the prediction of N-acetyltransferase 2 (NAT2) phenotypes with respect to enzyme activity and urinary bladder cancer risk

The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

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