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Dual-specificity MAP kinase phosphatases (MKPs) and cancer

Cancer and metastasis reviews, 2008-06, Vol.27 (2), p.253-261

Keyse, Stephen M.

2008

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Dual-specificity MAP kinase phosphatases in health and disease

Biochimica et biophysica acta. Molecular cell research, 2019-01, Vol.1866 (1), p.124-143

2019

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Diverse physiological functions for dual-specificity MAP kinase phosphatases

Journal of cell science, 2006-11, Vol.119 (22), p.4607-4615

2006

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Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (3), p.E317-E326

2017

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Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling

PLoS genetics, 2011-08, Vol.7 (8), p.e1002238

2011

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Suppression of mutant Kirsten-RAS (KRAS G12D )-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6

Oncogene, 2022-05, Vol.41 (20), p.2811-2823

2022

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Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

Molecular and cellular biology, 2016-09, Vol.36 (18), p.2403-2417

2016

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Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ⁶¹ᴸ)-driven SerpinB2 expression

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18267-18272

2014

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Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling

The FEBS journal, 2013-01, Vol.280 (2), p.489-504

2013

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Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

Biochemical journal, 2008-06, Vol.412 (2), p.287-298

2008

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The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)

Seminars in cell & developmental biology, 2016-02, Vol.50, p.125-132

2016

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Specific Inactivation and Nuclear Anchoring of Extracellular Signal-Regulated Kinase 2 by the Inducible Dual-Specificity Protein Phosphatase DUSP5

Molecular and Cellular Biology, 2005-03, Vol.25 (5), p.1830-1845

2005

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Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK

Cellular signalling, 2009-12, Vol.21 (12), p.1794-1805

2009

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Both Nuclear-Cytoplasmic Shuttling of the Dual Specificity Phosphatase MKP-3 and Its Ability to Anchor MAP Kinase in the Cytoplasm Are Mediated by a Conserved Nuclear Export Signal

The Journal of biological chemistry, 2004-10, Vol.279 (40), p.41882-41891

2004

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Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite

Development (Cambridge), 2005-03, Vol.132 (6), p.1305-1314

2005

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Negative Feedback Regulation of FGF Signaling Levels by Pyst1/MKP3 in Chick Embryos

Current biology, 2003-06, Vol.13 (12), p.1009-1018

2003

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Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif

The Journal of biological chemistry, 2009-07, Vol.284 (29), p.19392-19401

2009

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DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5

Cellular signalling, 2008-05, Vol.20 (5), p.836-843

2008

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Regulation of MAPK-activated Protein Kinase 5 Activity and Subcellular Localization by the Atypical MAPK ERK4/MAPK4

The Journal of biological chemistry, 2006-11, Vol.281 (46), p.35499-35510

2006

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Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

The EMBO journal, 2004-12, Vol.23 (24), p.4780-4791

2004

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Protein phosphatases and the regulation of mitogen-activated protein kinase signalling

Current Opinion in Cell Biology, 2000-04, Vol.12 (2), p.186-192

Keyse, Stephen M

2000

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The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

The Journal of pathology, 2019-11, Vol.249 (3), p.332-342

2019

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The Dual-Specificity Protein Phosphatase DUSP9/MKP-4 Is Essential for Placental Function but Is Not Required for Normal Embryonic Development

Molecular and Cellular Biology, 2005-09, Vol.25 (18), p.8323-8333

2005

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Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

Nature (London), 1992-10, Vol.359 (6396), p.644-647

1992

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New insights into the activation, interaction partners and possible functions of MK5/PRAK

Frontiers in bioscience, 2016-01, Vol.21 (2), p.374-384, Article 4394

2016

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Dual-specificity MAP kinase phosphatases (MKPs) and cancer

Dual-specificity MAP kinase phosphatases in health and disease

Diverse physiological functions for dual-specificity MAP kinase phosphatases

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling

Suppression of mutant Kirsten-RAS (KRAS G12D )-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ⁶¹ᴸ)-driven SerpinB2 expression

Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)

Specific Inactivation and Nuclear Anchoring of Extracellular Signal-Regulated Kinase 2 by the Inducible Dual-Specificity Protein Phosphatase DUSP5

Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK

Both Nuclear-Cytoplasmic Shuttling of the Dual Specificity Phosphatase MKP-3 and Its Ability to Anchor MAP Kinase in the Cytoplasm Are Mediated by a Conserved Nuclear Export Signal

Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite

Negative Feedback Regulation of FGF Signaling Levels by Pyst1/MKP3 in Chick Embryos

Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif

DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5

Regulation of MAPK-activated Protein Kinase 5 Activity and Subcellular Localization by the Atypical MAPK ERK4/MAPK4

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling

The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

The Dual-Specificity Protein Phosphatase DUSP9/MKP-4 Is Essential for Placental Function but Is Not Required for Normal Embryonic Development

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

New insights into the activation, interaction partners and possible functions of MK5/PRAK

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