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4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition and Attention

Journal of medicinal chemistry, 2005-01, Vol.48 (1), p.38-55

2005

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Perspectives on cognitive domains, H3 receptor ligands and neurological disease

Expert opinion on investigational drugs, 2004-10, Vol.13 (10), p.1237-1248

2004

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A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofurans

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.689-693

2004

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Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.897

2003

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Effects of histamine H3 receptor antagonists in two models of spatial learning

Behavioural brain research, 2005-04, Vol.159 (2), p.295-300

2005

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An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity

The Journal of pharmacology and experimental therapeutics, 2007-12, Vol.323 (3), p.888

2007

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Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.887

2003

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Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup

Behavioural brain research, 2002-04, Vol.131 (1-2), p.151-161

2002

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Enhancement of prepulse inhibition of startle in mice by the H3 receptor antagonists thioperamide and ciproxifan

Behavioural brain research, 2004-08, Vol.153 (1), p.69-76

2004

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Structure–activity relationships of arylbenzofuran H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2559-2563

2005

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Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist

Biochemical pharmacology, 2004-09, Vol.68 (5), p.933-945

2004

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G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations

The Journal of pharmacology and experimental therapeutics, 2005-07, Vol.314 (1), p.271

2005

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Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships

Journal of medicinal chemistry, 2009-08, Vol.52 (15), p.4640-4649

2009

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In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists : Trends across multiple chemical series

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (1), p.355-359

2008

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An Efficient Multigram Synthesis of the Potent Histamine H3 Antagonist GT-2331 and the Reassessment of the Absolute Configuration

Journal of organic chemistry, 2004-01, Vol.69 (1), p.192-194

2004

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Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: Novel and selective histamine H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1325-1328

2003

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H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

Pharmacology, biochemistry and behavior, 2010-03, Vol.95 (1), p.41-50

2010

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Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist

The Journal of pharmacology and experimental therapeutics, 2012-10, Vol.343 (1), p.233

2012

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Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist

The Journal of pharmacology and experimental therapeutics, 2005-04, Vol.313 (1), p.176

2005

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Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor

Journal of biomolecular screening, 2002-10, Vol.7 (5), p.466-475

2002

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Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model

Pharmacology, biochemistry and behavior, 2002-06, Vol.72 (3), p.741-750

2002

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Assessment of pharmacology and potential anti-obesity properties of H3 receptor antagonists/inverse agonists

Expert opinion on investigational drugs, 2005-03, Vol.14 (3), p.223-241

2005

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Genetic and pharmacological aspects of histamine H3 receptor heterogeneity

Life sciences (1973), 2003-10, Vol.73 (24), p.3043-3072

2003

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Structure−Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H4 Receptor Ligands

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6571-6580

2008

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The Alkaloid Conessine and Analogues as Potent Histamine H3 Receptor Antagonists

Journal of medicinal chemistry, 2008-09, Vol.51 (17), p.5423-5430

2008

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4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition and Attention

Perspectives on cognitive domains, H3 receptor ligands and neurological disease

A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofurans

Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

Effects of histamine H3 receptor antagonists in two models of spatial learning

An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity

Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup

Enhancement of prepulse inhibition of startle in mice by the H3 receptor antagonists thioperamide and ciproxifan

Structure–activity relationships of arylbenzofuran H3 receptor antagonists

Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist

G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations

Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships

In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists : Trends across multiple chemical series

An Efficient Multigram Synthesis of the Potent Histamine H3 Antagonist GT-2331 and the Reassessment of the Absolute Configuration

Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: Novel and selective histamine H3 receptor antagonists

H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist

Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist

Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor

Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model

Assessment of pharmacology and potential anti-obesity properties of H3 receptor antagonists/inverse agonists

Genetic and pharmacological aspects of histamine H3 receptor heterogeneity

Structure−Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H4 Receptor Ligands

The Alkaloid Conessine and Analogues as Potent Histamine H3 Receptor Antagonists

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