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Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.10176-10191

2014

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Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7686-7695

2012

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Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.9080-9093

2016

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Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Journal of medicinal chemistry, 2012-06, Vol.55 (12), p.5887-5900

2012

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Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles

ACS medicinal chemistry letters, 2017-09, Vol.8 (9), p.936-940

2017

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Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4296-4302

2012

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Identification of GNE-293, a potent and selective PI3Kδ inhibitor: Navigating in vitro genotoxicity while improving potency and selectivity

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (17), p.4953-4959

2013

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Substituent Effects on Edge-to-Face Aromatic Interactions

Chemistry : a European journal, 2002-07, Vol.8 (13), p.2847-2859

2002

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Redox-dependent binding ability of a flavin cyclophane in aqueous solution: hydrophobic stacking versus cavity-inclusion complexation

Journal of the American Chemical Society, 1990-02, Vol.112 (5), p.1783-1790

1990

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Molecular receptors. Synthesis and x-ray crystal structure of a calix[4] arene tetracarbonate-acetonitrile (1:1) clathrate

Journal of organic chemistry, 1986-09, Vol.51 (19), p.3581-3584

1986

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Spirocyclic NK1 antagonists I:[4.5] and [5.5]-spiroketals

Bioorganic & medicinal chemistry letters, 2002-09, Vol.12 (18), p.2515-2518

2002

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Substituent effects on edge-to-face aromatic interactions

Chemistry : a European journal, 2002-07, Vol.8 (13), p.2848-2859

2002

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Caesium-selective poly(vinyl chloride) membrane electrodes based on calix[6]arene esters

Analyst (London), 1990, Vol.115 (9), p.1207

1990

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Potent and selective inhibitors of PI3KI': Obtaining isoform selectivity from the affinity pocket and tryptophan shelf

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4296-4302

2012

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Cation complexation by chemically modified calixarenes. Part 7. Transport of alkali cations by p-tert-butylcalix[n]arene esters and amides

Journal of the Chemical Society, Perkin Transactions 2, 1995 (1), p.113

1995

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Structure–activity relationship for quantifying aromatic interactions

Chemical communications (Cambridge, England), 1998 (7), p.775-776

1998

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Synthesis, X-ray crystal structures, and cation transfer properties of alkyl calixaryl acetates, a new series of molecular receptors

Journal of the Chemical Society. Chemical communications, 1985 (7), p.388-390

1985

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Synthesis, X-ray crystal structure, and cation transfer properties of a Calix[4]arene tetraketone, a new versatile molecular receptor

Journal of the Chemical Society. Chemical communications, 1987 (8), p.584-585

1987

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Quantitative Measurements of Edge-to-Face Aromatic Interactions by Using Chemical Double-Mutant Cycles

Chemistry : a European journal, 2001-11, Vol.7 (22), p.4854-4862

2001

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Assessment of sodium-selective ion-selective electrodes based on methyl ketone derivative of p-tert-butylcalix[4]arene

Electroanalysis (New York, N.Y.), 1991-05, Vol.3 (4-5), p.371-375

1991

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Synthesis, x-ray crystal structures, and cation-binding properties of alkyl calixaryl esters and ketones, a new family of macrocyclic molecular receptors

Journal of the American Chemical Society, 1989-11, Vol.111 (23), p.8681-8691

1989

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Stereoselective Synthesis of a Potent Human NK1 Receptor Antagonist via Acyl-Claisen Rearrangement

Synlett, 2006-03, Vol.2006 (4), p.0600-0604

2006

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Neurokinin receptor antagonists

Expert opinion on therapeutic patents, 1999-05, Vol.9 (5), p.571-582

1999

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Chemical Double-Mutant Cycles for the Measurement of Weak Intermolecular Interactions: Edge-to-Face Aromatic Interactions

Angewandte Chemie (International ed.), 1996-07, Vol.35 (13-14), p.1542-1544

1996

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Neurokinin receptor antagonists

Expert opinion on therapeutic patents, 1997-01, Vol.7 (1), p.43-54

1997

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Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles

Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf

Identification of GNE-293, a potent and selective PI3Kδ inhibitor: Navigating in vitro genotoxicity while improving potency and selectivity

Substituent Effects on Edge-to-Face Aromatic Interactions

Redox-dependent binding ability of a flavin cyclophane in aqueous solution: hydrophobic stacking versus cavity-inclusion complexation

Molecular receptors. Synthesis and x-ray crystal structure of a calix[4] arene tetracarbonate-acetonitrile (1:1) clathrate

Spirocyclic NK1 antagonists I:[4.5] and [5.5]-spiroketals

Substituent effects on edge-to-face aromatic interactions

Caesium-selective poly(vinyl chloride) membrane electrodes based on calix[6]arene esters

Potent and selective inhibitors of PI3KI': Obtaining isoform selectivity from the affinity pocket and tryptophan shelf

Cation complexation by chemically modified calixarenes. Part 7. Transport of alkali cations by p-tert-butylcalix[n]arene esters and amides

Structure–activity relationship for quantifying aromatic interactions

Synthesis, X-ray crystal structures, and cation transfer properties of alkyl calixaryl acetates, a new series of molecular receptors

Synthesis, X-ray crystal structure, and cation transfer properties of a Calix[4]arene tetraketone, a new versatile molecular receptor

Quantitative Measurements of Edge-to-Face Aromatic Interactions by Using Chemical Double-Mutant Cycles

Assessment of sodium-selective ion-selective electrodes based on methyl ketone derivative of p-tert-butylcalix[4]arene

Synthesis, x-ray crystal structures, and cation-binding properties of alkyl calixaryl esters and ketones, a new family of macrocyclic molecular receptors

Stereoselective Synthesis of a Potent Human NK1 Receptor Antagonist via Acyl-Claisen Rearrangement

Neurokinin receptor antagonists

Chemical Double-Mutant Cycles for the Measurement of Weak Intermolecular Interactions: Edge-to-Face Aromatic Interactions

Neurokinin receptor antagonists

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