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Late-stage meta-C-H alkylation of pharmaceuticals to modulate biological properties and expedite molecular optimisation in a single step

Nature communications, 2024-04, Vol.15 (1), p.3349-3349, Article 3349

2024

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Late-stage synthesis of heterobifunctional molecules for PROTAC applications via ruthenium-catalysed C‒H amidation

Nature communications, 2023-12, Vol.14 (1), p.8222-8222, Article 8222

2023

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General Cyclopropane Assembly by Enantioselective Transfer of a Redox‐Active Carbene to Aliphatic Olefins

Angewandte Chemie (International ed.), 2019-04, Vol.58 (18), p.5930-5935

International ed. in English, 2019

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Late‐Stage Functionalization of Histidine in Unprotected Peptides

Angewandte Chemie International Edition, 2019-12, Vol.58 (52), p.19096-19102

International ed. in English, 2019

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Mechanism and regioselectivity of the anionic oxidative rearrangement of 1,3-diketones towards all-carbon quaternary carboxylates

Chemical communications (Cambridge, England), 2019-07, Vol.55 (6), p.8844-8847

2019

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Selective Heterogeneous C−H Activation/Halogenation Reactions Catalyzed by Pd@MOF Nanocomposites

Chemistry : a European journal, 2016-03, Vol.22 (11), p.3729-3737

2016

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Electrocatalyzed direct arene alkenylations without directing groups for selective late-stage drug diversification

Nature communications, 2023-07, Vol.14 (1), p.4224-4224, Article 4224

2023

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Gold(I)-Catalyzed Stereoselective Olefin Cyclopropanation

Journal of the American Chemical Society, 2005-12, Vol.127 (51), p.18002-18003

2005

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Base- and Additive-Free Ir-Catalyzed ortho-Iodination of Benzoic Acids: Scope and Mechanistic Investigations

ACS catalysis, 2018-02, Vol.8 (2), p.920-925

2018

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Cobalt-catalysed C-H methylation for late-stage drug diversification

Nature chemistry, 2020-06, Vol.12 (6), p.511

2020

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Highly Functionalized Biaryls via Suzuki-Miyaura Cross-Coupling Catalyzed by Pd@MOF under Batch and Continuous Flow Regimes

ChemSusChem, 2015-01, Vol.8 (1), p.123-130

2015

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Direct Synthesis of N‑Alkyl Arylglycines by Organocatalytic Asymmetric Transfer Hydrogenation of N‑Alkyl Aryl Imino Esters

Organic letters, 2017-10, Vol.19 (20), p.5541-5544

2017

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A General Suzuki Cross-Coupling Reaction of Heteroaromatics Catalyzed by Nanopalladium on Amino-Functionalized Siliceous Mesocellular Foam

Journal of organic chemistry, 2014-05, Vol.79 (9), p.3946-3954

2014

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A Predictive Tool for Electrophilic Aromatic Substitutions Using Machine Learning

Journal of organic chemistry, 2019-04, Vol.84 (8), p.4695-4703

2019

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Ruthenium‐Catalyzed Aminocarbonylation with Isocyanates Through Weak Coordinating Groups

Chemistry : a European journal, 2023-11, Vol.29 (61), p.e202302023-e202302023

2023

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Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

Green chemistry : an international journal and green chemistry resource : GC, 2016-01, Vol.18 (9), p.2632-2637

2016

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Oxalate Oxidase for In Situ H2O2‐Generation in Unspecific Peroxygenase‐Catalysed Drug Oxyfunctionalisations

Angewandte Chemie (International ed.), 2022-09, Vol.61 (39), p.n/a

International ed. in English, 2022

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Ir(III)-Catalyzed Selective ortho-Monoiodination of Benzoic Acids with Unbiased C-H Bonds

Chemistry : a European journal, 2020-08

2020

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Late‐Stage Amination of Drug‐Like Benzoic Acids: Access to Anilines and Drug Conjugates through Directed Iridium‐Catalyzed C−H Activation

Chemistry : a European journal, 2021-12, Vol.27 (72), p.18188-18200

2021

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Selective C–H Iodination of Weinreb Amides and Benzamides through Iridium Catalysis in Solution and under Mechanochemical Conditions

Organic letters, 2024-04, Vol.26 (14), p.2800-2805

2024

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HSQC Spectra Simulation and Matching for Molecular Identification

Journal of chemical information and modeling, 2024-04, Vol.64 (8), p.3180-3191

2024

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Regiodivergent Radical Termination for Intermolecular Biocatalytic C–C Bond Formation

Journal of the American Chemical Society, 2024-02, Vol.146 (7), p.5005-5010

2024

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A Biocatalytic Route to P-Chirogenic Compounds by Lipase-Catalyzed Desymmetrization of a Prochiral Phosphine−Borane

Organic letters, 2005-10, Vol.7 (22), p.4991-4994

2005

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Heterogeneous Copper‐Catalyzed Cross‐Coupling for Sustainable Synthesis of Chiral Allenes: Application to the Synthesis of Allenic Natural Products

Angewandte Chemie International Edition, 2023-12, Vol.62 (50), p.e202314512-n/a

International ed. in English, 2023

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Late-stage meta-C-H alkylation of pharmaceuticals to modulate biological properties and expedite molecular optimisation in a single step

Late-stage synthesis of heterobifunctional molecules for PROTAC applications via ruthenium-catalysed C‒H amidation

General Cyclopropane Assembly by Enantioselective Transfer of a Redox‐Active Carbene to Aliphatic Olefins

Late‐Stage Functionalization of Histidine in Unprotected Peptides

Mechanism and regioselectivity of the anionic oxidative rearrangement of 1,3-diketones towards all-carbon quaternary carboxylates

Selective Heterogeneous C−H Activation/Halogenation Reactions Catalyzed by Pd@MOF Nanocomposites

Electrocatalyzed direct arene alkenylations without directing groups for selective late-stage drug diversification

Gold(I)-Catalyzed Stereoselective Olefin Cyclopropanation

Base- and Additive-Free Ir-Catalyzed ortho-Iodination of Benzoic Acids: Scope and Mechanistic Investigations

Cobalt-catalysed C-H methylation for late-stage drug diversification

Highly Functionalized Biaryls via Suzuki-Miyaura Cross-Coupling Catalyzed by Pd@MOF under Batch and Continuous Flow Regimes

Direct Synthesis of N‑Alkyl Arylglycines by Organocatalytic Asymmetric Transfer Hydrogenation of N‑Alkyl Aryl Imino Esters

A General Suzuki Cross-Coupling Reaction of Heteroaromatics Catalyzed by Nanopalladium on Amino-Functionalized Siliceous Mesocellular Foam

A Predictive Tool for Electrophilic Aromatic Substitutions Using Machine Learning

Ruthenium‐Catalyzed Aminocarbonylation with Isocyanates Through Weak Coordinating Groups

Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

Oxalate Oxidase for In Situ H2O2‐Generation in Unspecific Peroxygenase‐Catalysed Drug Oxyfunctionalisations

Ir(III)-Catalyzed Selective ortho-Monoiodination of Benzoic Acids with Unbiased C-H Bonds

Late‐Stage Amination of Drug‐Like Benzoic Acids: Access to Anilines and Drug Conjugates through Directed Iridium‐Catalyzed C−H Activation

Selective C–H Iodination of Weinreb Amides and Benzamides through Iridium Catalysis in Solution and under Mechanochemical Conditions

HSQC Spectra Simulation and Matching for Molecular Identification

Regiodivergent Radical Termination for Intermolecular Biocatalytic C–C Bond Formation

A Biocatalytic Route to P-Chirogenic Compounds by Lipase-Catalyzed Desymmetrization of a Prochiral Phosphine−Borane

Heterogeneous Copper‐Catalyzed Cross‐Coupling for Sustainable Synthesis of Chiral Allenes: Application to the Synthesis of Allenic Natural Products

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