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Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner

Cell stem cell, 2014-01, Vol.14 (1), p.68-80

2014

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Cobimetinib combined with vemurafenib in advanced BRAF(V600)-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial

The lancet oncology, 2016-09, Vol.17 (9), p.1248-1260

2016

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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

Cell chemical biology, 2020-01, Vol.27 (1), p.41-46.e17

2020

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Modeling initiation of Ewing sarcoma in human neural crest cells

PloS one, 2011-04, Vol.6 (4), p.e19305-e19305

2011

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Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF -Mutant Melanoma

Clinical cancer research, 2020-01, Vol.26 (1), p.46-53

2020

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Phase III Trial Comparing Concurrent Biochemotherapy With Cisplatin, Vinblastine, Dacarbazine, Interleukin-2, and Interferon Alfa-2b With Cisplatin, Vinblastine, and Dacarbazine Alone in Patients With Metastatic Malignant Melanoma (E3695): A Trial Coordinated by the Eastern Cooperative Oncology Group

Journal of clinical oncology, 2008-12, Vol.26 (35), p.5748-5754

2008

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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

Journal of medicinal chemistry, 2021-12, Vol.64 (23), p.17146-17183

2021

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Outcome-Driven Cluster Analysis with Application to Microarray Data

PloS one, 2015-11, Vol.10 (11), p.e0141874-e0141874

2015

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B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma

The American journal of surgical pathology, 2010-03, Vol.34 (3), p.327-340

2010

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A Phase II Randomized Trial (GO27827) of First‐Line FOLFOX Plus Bevacizumab with or Without the MET Inhibitor Onartuzumab in Patients with Metastatic Colorectal Cancer

The oncologist (Dayton, Ohio), 2017-03, Vol.22 (3), p.264-271

2017

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Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study

Journal of translational medicine, 2017-06, Vol.15 (1), p.146-9, Article 146

2017

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Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase

Bioorganic & medicinal chemistry letters, 2021-05, Vol.39, p.127904-127904, Article 127904

2021

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BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression

Cancer research (Chicago, Ill.), 2008-08, Vol.68 (16), p.6507-6515

2008

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PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Cancer research (Chicago, Ill.), 2017-09, Vol.77 (17), p.4613-4625

2017

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Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib-treated Patients with BRAF V600 -mutated Metastatic Melanoma

Clinical cancer research, 2019-06, Vol.25 (11), p.3239-3246

2019

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Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program

PloS one, 2015-10, Vol.10 (10), p.e0139679

2015

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Informatively clustering longitudinal microarrays using binary or survival outcome data

Communication in statistics. Case studies and data analysis, 2018-01, Vol.4 (1), p.18-27

2018

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Ewing Tumors That Do Not Overexpress BMI-1 Are a Distinct Molecular Subclass with Variant Biology: A Report from the Children's Oncology Group

Clinical cancer research, 2011, Vol.17 (1), p.56-66

2011

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Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.8962-8987

2024

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Diverse Drug Combinations with an Eed Inhibitor Confer Context-Specific Benefit across Multiple Tumor Types

Blood, 2021-11, Vol.138 (Supplement 1), p.2274-2274

2021

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5-Year Outcomes with Cobimetinib plus Vemurafenib in BRAF V600 Mutation–Positive Advanced Melanoma: Extended Follow-up of the coBRIM Study

Clinical cancer research, 2021-10, Vol.27 (19), p.5225-5235

2021

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5-Year Outcomes with Cobimetinib plus Vemurafenib in BRAFV600 Mutation-Positive Advanced Melanoma: Extended Follow-up of the coBRIM Study

Clinical cancer research, 2021-10, Vol.27 (19), p.5225-5235

2021

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BMI-1 suppresses contact inhibition and stabilizes YAP in Ewing sarcoma

Oncogene, 2011-04, Vol.30 (17), p.2077-2085

2011

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Varied Clinical Ketogenic Diets Elicit Both Shared and Unique Functional and Taxonomic Responses on the Human Gut Microbiome in Refractory Epilepsy

Current developments in nutrition, 2022-06, Vol.6 (Supplement_1), p.1024-1024

2022

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Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner

Cobimetinib combined with vemurafenib in advanced BRAF(V600)-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial

EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

Modeling initiation of Ewing sarcoma in human neural crest cells

Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF -Mutant Melanoma

Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

Outcome-Driven Cluster Analysis with Application to Microarray Data

B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma

A Phase II Randomized Trial (GO27827) of First‐Line FOLFOX Plus Bevacizumab with or Without the MET Inhibitor Onartuzumab in Patients with Metastatic Colorectal Cancer

Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study

Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase

BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib-treated Patients with BRAF V600 -mutated Metastatic Melanoma

Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program

Informatively clustering longitudinal microarrays using binary or survival outcome data

Cobimetinib combined with vemurafenib in advanced BRAFV600 -mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial

Ewing Tumors That Do Not Overexpress BMI-1 Are a Distinct Molecular Subclass with Variant Biology: A Report from the Children's Oncology Group

Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches

Diverse Drug Combinations with an Eed Inhibitor Confer Context-Specific Benefit across Multiple Tumor Types

5-Year Outcomes with Cobimetinib plus Vemurafenib in BRAF V600 Mutation–Positive Advanced Melanoma: Extended Follow-up of the coBRIM Study

5-Year Outcomes with Cobimetinib plus Vemurafenib in BRAFV600 Mutation-Positive Advanced Melanoma: Extended Follow-up of the coBRIM Study

BMI-1 suppresses contact inhibition and stabilizes YAP in Ewing sarcoma

Varied Clinical Ketogenic Diets Elicit Both Shared and Unique Functional and Taxonomic Responses on the Human Gut Microbiome in Refractory Epilepsy

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