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Substitution of terminal amide with 1H-1,2,3-triazole: Identification of unexpected class of potent antibacterial agents

Bioorganic & medicinal chemistry letters, 2018-03, Vol.28 (5), p.884-891

2018

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Novel 5-methyl-2-phenylphenanthridium derivatives as FtsZ-targeting antibacterial agents from structural simplification of natural product sanguinarine

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1825-1831

2018

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Design, synthesis and biological activity evaluation of novel 2,6-difluorobenzamide derivatives through FtsZ inhibition

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.958-962

2017

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Synthesis and antibacterial activity of 5-methylphenanthridium derivatives as FtsZ inhibitors

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (15), p.3399-3402

2017

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Substitution of terminal amide with 1 H -1,2,3-triazole: Identification of unexpected class of potent antibacterial agents

Bioorganic & medicinal chemistry letters, 2018-03, Vol.28 (5), p.884-891

2018

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Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT 2C receptor

Bioorganic & medicinal chemistry letters, , Vol.26 (24), p.5877-5882

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Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT2C receptor

Bioorganic & medicinal chemistry letters, 2021-04, Vol.38, p.127872-127872, Article 127872

2021

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Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays

Bioorganic & medicinal chemistry letters, 2020-03, Vol.30 (5), p.126929, Article 126929

2020

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Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT2C receptor

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (24), p.5877-5882

2016

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Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.3134-3141

2011

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Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1750-1755

2012

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Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT 2C receptor

Bioorganic & medicinal chemistry letters, 2021-04, Vol.38, p.127872

2021

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Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (15), p.3034-3038

2015

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Discovery of a lead series of potent benzodiazepine 5-HT 2C receptor agonists with high selectivity in functional and binding assays

Bioorganic & medicinal chemistry letters, 2020-03, Vol.30 (5), p.126929

2020

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A new family of H3 receptor antagonists based on the natural product Conessine

Bioorganic & medicinal chemistry letters, 2008-02, Vol.18 (4), p.1490-1494

2008

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Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat

Bioorganic & medicinal chemistry letters, 2015-03, Vol.25 (5), p.1030-1035

2015

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Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.322-326

2015

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Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.2925-2930

2002

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Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1

Bioorganic & medicinal chemistry letters, 2005-09, Vol.15 (17), p.3853-3856

2005

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Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxam i des as potent and selective CB sub(2) receptor agonists

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.322-326

2015

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Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.71-75

2012

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Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2565-2569

2005

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Design and construction of novel thrombin inhibitors featuring P3-P4 quaternary lactam dipeptide surrogates

Bioorganic & medicinal chemistry letters, 1998-09, Vol.8 (18), p.2501-2506

SEMPLE, J. E

1998

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Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (9), p.2797-2800

2010

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Novel, potent non-covalent thrombin inhibitors incorporating P3-lactam scaffolds

Bioorganic & medicinal chemistry letters, 2002-03, Vol.12 (5), p.743-748

2002

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Substitution of terminal amide with 1H-1,2,3-triazole: Identification of unexpected class of potent antibacterial agents

Novel 5-methyl-2-phenylphenanthridium derivatives as FtsZ-targeting antibacterial agents from structural simplification of natural product sanguinarine

Design, synthesis and biological activity evaluation of novel 2,6-difluorobenzamide derivatives through FtsZ inhibition

Synthesis and antibacterial activity of 5-methylphenanthridium derivatives as FtsZ inhibitors

Substitution of terminal amide with 1 H -1,2,3-triazole: Identification of unexpected class of potent antibacterial agents

Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT 2C receptor

Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT2C receptor

Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays

Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT2C receptor

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT 2C receptor

Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

Discovery of a lead series of potent benzodiazepine 5-HT 2C receptor agonists with high selectivity in functional and binding assays

A new family of H3 receptor antagonists based on the natural product Conessine

Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat

Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates

Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1

Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxam i des as potent and selective CB sub(2) receptor agonists

Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)

Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1

Design and construction of novel thrombin inhibitors featuring P3-P4 quaternary lactam dipeptide surrogates

Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)

Novel, potent non-covalent thrombin inhibitors incorporating P3-lactam scaffolds

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