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Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (15), p.1968-1973

2019

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Rho kinase, a promising drug target for neurological disorders

Nature reviews. Drug discovery, 2005-05, Vol.4 (5), p.387-398

2005

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Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer’s Disease: 2‑(3-Phenyl‑1H‑pyrazol-1-yl)-nicotinamides

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7123-7138

2017

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Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo

Journal of neurochemistry, 2007-10, Vol.103 (1), p.181-189

2007

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A new mild method for the synthesis of amidines

Tetrahedron letters, 1999-09, Vol.40 (39), p.7067-7070

1999

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Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design

Journal of medicinal chemistry, 2018-12, Vol.61 (24), p.11074-11100

2018

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Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1′ Extension

ACS medicinal chemistry letters, 2018-03, Vol.9 (3), p.221-226

2018

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A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats

Biochemical pharmacology, 2012-02, Vol.83 (3), p.406-418

2012

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The Spinning Disk Reactor for Polymers and Nanoparticles

Macromolecular reaction engineering, 2013-02, Vol.7 (2), p.98-106

2013

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Discovery of diphenyl lactam derivatives as N-type calcium channel blockers

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1716-1718

2012

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Characterization of the Cardiovascular Profile of Two Novel Ca 2+ Channels Blockers

The FASEB journal, 2011-04, Vol.25 (S1)

2011

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Characterization of the Cardiovascular Profile of Two Novel Ca2+ Channels Blockers

The FASEB journal, 2011, Vol.25, p.1021.14-1021.14

2011

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Orally active thrombin inhibitors. Part 2: Optimization of the P2-moiety

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2648-2653

2006

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Technical Scale Synthesis of a New and Highly Potent Thrombin Inhibitor

Synthesis (Stuttgart), 2004, Vol.2004 (14), p.2367-2375

2004

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Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (24), p.5567-5573

2005

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Technical Scale Synthesis of a New and Highly Potent Thrombin Inhibitor

Synthesis (Stuttgart), 2004-10, Vol.2004 (14), p.2367-2375

2004

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Orally active thrombin inhibitors. Part 1: Optimization of the P1-moiety

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2641-2647

2006

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Synthesis, characterization and reactivity of amido titanium and zirconium complexes

Journal of organometallic chemistry, 1996-11, Vol.525 (1), p.81-87

1996

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Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective alpha(V)beta(3) antagonists

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.441-446

2002

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Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective αVβ3 antagonists

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.441-446

2002

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d-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (12), p.2029-2033

2003

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Thermal decomposition of [Me3SiNCH2CH2NSiMe3] · Li2(THF)2 to [LiN(SiMe3)2 · THF]2 via a 1,4-trimethylsilyl shift

Journal of organometallic chemistry, 1997-12, Vol.549 (1-2), p.39-43

1997

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Synthesis and SAR of highly potent dual 5-HT 1A and 5-HT 1B antagonists as potential antidepressant drugs

Bioorganic & medicinal chemistry letters, 2005, Vol.15 (24), p.5567-5573

2005

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Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective α Vβ 3 antagonists

Bioorganic & medicinal chemistry letters, 2002, Vol.12 (3), p.441-446

2002

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Thermal decomposition of [Me 3SiNCH 2CH 2NSiMe 3] · Li 2(THF) 2 to [LiN(SiMe3) 2 · THF] 2 via a 1,4-trimethylsilyl shift

Journal of organometallic chemistry, 1997, Vol.549 (1), p.39-43

1997

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Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability

Rho kinase, a promising drug target for neurological disorders

Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer’s Disease: 2‑(3-Phenyl‑1H‑pyrazol-1-yl)-nicotinamides

Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo

A new mild method for the synthesis of amidines

Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design

Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1′ Extension

A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats

The Spinning Disk Reactor for Polymers and Nanoparticles

Discovery of diphenyl lactam derivatives as N-type calcium channel blockers

Characterization of the Cardiovascular Profile of Two Novel Ca 2+ Channels Blockers

Characterization of the Cardiovascular Profile of Two Novel Ca2+ Channels Blockers

Orally active thrombin inhibitors. Part 2: Optimization of the P2-moiety

Technical Scale Synthesis of a New and Highly Potent Thrombin Inhibitor

Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs

Technical Scale Synthesis of a New and Highly Potent Thrombin Inhibitor

Orally active thrombin inhibitors. Part 1: Optimization of the P1-moiety

Synthesis, characterization and reactivity of amido titanium and zirconium complexes

Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective alpha(V)beta(3) antagonists

Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective αVβ3 antagonists

d-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety

Thermal decomposition of [Me3SiNCH2CH2NSiMe3] · Li2(THF)2 to [LiN(SiMe3)2 · THF]2 via a 1,4-trimethylsilyl shift

Synthesis and SAR of highly potent dual 5-HT 1A and 5-HT 1B antagonists as potential antidepressant drugs

Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective α Vβ 3 antagonists

Thermal decomposition of [Me 3SiNCH 2CH 2NSiMe 3] · Li 2(THF) 2 to [LiN(SiMe3) 2 · THF] 2 via a 1,4-trimethylsilyl shift

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