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Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease

Frontiers in pharmacology, 2019-09, Vol.10, p.1047-1047

2019

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The emerging role of peptidyl‐prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease

Journal of neurochemistry, 2015-04, Vol.133 (1), p.1-13

2015

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Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease

International journal of molecular sciences, 2018-12, Vol.20 (1), p.79

2018

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Hsp90 activator Aha1 drives production of pathological tau aggregates

Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (36), p.9707-9712

2017

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Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies

Frontiers in neuroscience, 2017-12, Vol.11, p.724-724

2017

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Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation

The Journal of neuroscience, 2013-05, Vol.33 (22), p.9498-9507

2013

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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

The Journal of clinical investigation, 2013-10, Vol.123 (10), p.4158-4169

2013

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Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

Nature communications, 2018-10, Vol.9 (1), p.4532-13, Article 4532

2018

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Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war

Nature communications, 2020-11, Vol.11 (1), p.6046-6046, Article 6046

2020

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Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency

PloS one, 2014-09, Vol.9 (9), p.e107241-e107241

2014

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Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model

Scientific reports, 2023-01, Vol.13 (1), p.317-317, Article 317

2023

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Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases

Frontiers in neuroscience, 2019-11, Vol.13, p.1263

2019

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Human cyclophilin 40 unravels neurotoxic amyloids

PLoS biology, 2017-06, Vol.15 (6), p.e2001336

2017

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Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology

The Journal of clinical investigation, 2021-02, Vol.131 (4), p.1-22

2021

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Evidence against a contribution of the CCAAT-enhancer binding protein homologous protein (CHOP) in mediating neurotoxicity in rTg4510 mice

Scientific reports, 2022-05, Vol.12 (1), p.7372-7372, Article 7372

2022

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Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain

International journal of molecular sciences, 2022-01, Vol.23 (2), p.851

2022

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The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

The Journal of neuroscience, 2010-01, Vol.30 (2), p.591-599

2010

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Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice

Acta neuropathologica communications, 2021-04, Vol.9 (1), p.65-65, Article 65

2021

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Imbalance of Hsp70 family variants fosters tau accumulation

The FASEB journal, 2013-04, Vol.27 (4), p.1450-1459

2013

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Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

Scientific reports, 2017-12, Vol.7 (1), p.17951-9, Article 17951

2017

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SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk

Molecular therapy. Methods & clinical development, 2022-12, Vol.27, p.217-229

2022

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Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance

PloS one, 2012-04, Vol.7 (4), p.e35566

2012

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Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels

International journal of molecular sciences, 2020-07, Vol.21 (15), p.5442

2020

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Heparan Sulfate Proteoglycans in Tauopathy

Biomolecules (Basel, Switzerland), 2022-11, Vol.12 (12), p.1792

2022

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Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice

The Journal of neuroscience, 2010-11, Vol.30 (46), p.15374-15382

2010

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Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease

The emerging role of peptidyl‐prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease

Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease

Hsp90 activator Aha1 drives production of pathological tau aggregates

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies

Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war

Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency

Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model

Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases

Human cyclophilin 40 unravels neurotoxic amyloids

Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology

Evidence against a contribution of the CCAAT-enhancer binding protein homologous protein (CHOP) in mediating neurotoxicity in rTg4510 mice

Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain

The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice

Imbalance of Hsp70 family variants fosters tau accumulation

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk

Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance

Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels

Heparan Sulfate Proteoglycans in Tauopathy

Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice

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