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Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo

Journal of medicinal chemistry, 2023-03, Vol.66 (6), p.3852-3865

2023

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Structural basis for GPR40 allosteric agonism and incretin stimulation

Nature communications, 2018-04, Vol.9 (1), p.1645-11, Article 1645

2018

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RV-GAN: Segmenting Retinal Vascular Structure in Fundus Photographs Using a Novel Multi-scale Generative Adversarial Network

Medical Image Computing and Computer Assisted Intervention – MICCAI 2021, 2021, p.34-44

2021

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Changes in interstitial cells and gastric excitability in a mouse model of sleeve gastrectomy

PloS one, 2022-06, Vol.17 (6), p.e0269909-e0269909

2022

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Secretin Inhibits Small Intestinal Motility via Interstitial Cells of Cajal and cAMP Mechanisms

Physiology (Bethesda, Md.), 2024-05, Vol.39 (S1)

2024

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Interstitial cells of the sip syncytium regulate basal membrane potential in murine gastric corpus

The FASEB journal, 2024-08, Vol.38 (16), p.e23863-n/a

2024

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A novel postsynaptic signal pathway of sympathetic neural regulation of murine colonic motility

The FASEB journal, 2020-04, Vol.34 (4), p.5563-5577

2020

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Ca 2+ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract

Physiological reviews, 2024-01, Vol.104 (1), p.329-398

2024

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A high throughput machine-learning driven analysis of Ca2+ spatio-temporal maps

Cell calcium (Edinburgh), 2020-11, Vol.91, p.102260-102260, Article 102260

2020

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Tonic inhibition of murine proximal colon is due to nitrergic suppression of Ca2+ signaling in interstitial cells of Cajal

Scientific reports, 2019-03, Vol.9 (1), Article 4402

2019

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Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

eLife, 2021-01, Vol.10

2021

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[(H2O)Zn(Imidazole)n]2+: the vital roles of coordination number and geometry in Zn–OH2 acidity and catalytic hydrolysis

Physical chemistry chemical physics : PCCP, 2018-01, Vol.20 (38), p.24979-24991

2018

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Spontaneous Ca(2+) transients in interstitial cells of Cajal located within the deep muscular plexus of the murine small intestine

The Journal of physiology, 2016-06, Vol.594 (12), p.3317-3338

2016

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Ca2+ transients in ICC-MY define the basis for the dominance of the corpus in gastric pacemaking

Cell calcium (Edinburgh), 2021-11, Vol.99, p.102472-102472, Article 102472

2021

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Na+/Ca2 + Exchange and Pacemaker Activity of Interstitial Cells of Cajal

Frontiers in physiology, 2020-03, Vol.11, p.230-230

2020

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Distribution and Ca(2+) signalling of fibroblast-like (PDGFR(+)) cells in the murine gastric fundus

The Journal of physiology, 2013-12, Vol.591 (24), p.6193-6208

2013

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Interstitial cell of Cajal-like cells (ICC-LC) exhibit dynamic spontaneous activity but are not functionally innervated in mouse urethra

Cell calcium (Edinburgh), 2024-11, Vol.123, p.102931, Article 102931

2024

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Excitatory cholinergic responses in mouse colon intramuscular interstitial cells of Cajal are due to enhanced Ca 2+ release via M 3 receptor activation

The FASEB journal, 2020-08, Vol.34 (8), p.10073-10095

2020

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Excitatory cholinergic responses in mouse colon intramuscular interstitial cells of Cajal are due to enhanced Ca2+ release via M3 receptor activation

The FASEB journal, 2020-08, Vol.34 (8), p.10073-10095

2020

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[(H 2 O)Zn(Imidazole) n ] 2+ : the vital roles of coordination number and geometry in Zn-OH 2 acidity and catalytic hydrolysis

Physical chemistry chemical physics : PCCP, 2018-10, Vol.20 (38), p.24979-24991

2018

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Ca 2+ signalling in interstitial cells of Cajal contributes to generation and maintenance of tone in mouse and monkey lower oesophageal sphincters

The Journal of physiology, 2022-06, Vol.600 (11), p.2613-2636

2022

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Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ

Journal of visualized experiments, 2019-01 (143)

2019

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Retropubic versus Transobturator Midurethral Slings for Stress Incontinence

The New England journal of medicine, 2010-06, Vol.362 (22), p.2066-2076

2010

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The effects of mitochondrial inhibitors on Ca2+ signalling and electrical conductances required for pacemaking in interstitial cells of Cajal in the mouse small intestine

Cell calcium (Edinburgh), 2018-06, Vol.72, p.1-17

2018

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805: PDGFRα+ INTERSTITIAL CELLS INTEGRATE INHIBITORY INPUTS BY VARIOUS SIGNALS TO COLONIC MOTILITY OF MOUSE AND HUMAN

Gastroenterology (New York, N.Y. 1943), 2022-05, Vol.162 (7), p.S-197-S-197

2022

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Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo

Structural basis for GPR40 allosteric agonism and incretin stimulation

RV-GAN: Segmenting Retinal Vascular Structure in Fundus Photographs Using a Novel Multi-scale Generative Adversarial Network

Changes in interstitial cells and gastric excitability in a mouse model of sleeve gastrectomy

Secretin Inhibits Small Intestinal Motility via Interstitial Cells of Cajal and cAMP Mechanisms

Interstitial cells of the sip syncytium regulate basal membrane potential in murine gastric corpus

A novel postsynaptic signal pathway of sympathetic neural regulation of murine colonic motility

Ca 2+ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract

A high throughput machine-learning driven analysis of Ca2+ spatio-temporal maps

Tonic inhibition of murine proximal colon is due to nitrergic suppression of Ca2+ signaling in interstitial cells of Cajal

Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

[(H2O)Zn(Imidazole)n]2+: the vital roles of coordination number and geometry in Zn–OH2 acidity and catalytic hydrolysis

Spontaneous Ca(2+) transients in interstitial cells of Cajal located within the deep muscular plexus of the murine small intestine

Ca2+ transients in ICC-MY define the basis for the dominance of the corpus in gastric pacemaking

Na+/Ca2 + Exchange and Pacemaker Activity of Interstitial Cells of Cajal

Distribution and Ca(2+) signalling of fibroblast-like (PDGFR(+)) cells in the murine gastric fundus

Interstitial cell of Cajal-like cells (ICC-LC) exhibit dynamic spontaneous activity but are not functionally innervated in mouse urethra

Excitatory cholinergic responses in mouse colon intramuscular interstitial cells of Cajal are due to enhanced Ca 2+ release via M 3 receptor activation

Excitatory cholinergic responses in mouse colon intramuscular interstitial cells of Cajal are due to enhanced Ca2+ release via M3 receptor activation

[(H 2 O)Zn(Imidazole) n ] 2+ : the vital roles of coordination number and geometry in Zn-OH 2 acidity and catalytic hydrolysis

Ca 2+ signalling in interstitial cells of Cajal contributes to generation and maintenance of tone in mouse and monkey lower oesophageal sphincters

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ

Retropubic versus Transobturator Midurethral Slings for Stress Incontinence

The effects of mitochondrial inhibitors on Ca2+ signalling and electrical conductances required for pacemaking in interstitial cells of Cajal in the mouse small intestine

805: PDGFRα+ INTERSTITIAL CELLS INTEGRATE INHIBITORY INPUTS BY VARIOUS SIGNALS TO COLONIC MOTILITY OF MOUSE AND HUMAN

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