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Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

Nature (London), 2016-10, Vol.538 (7625), p.350-355

2016

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Mechanisms and impact of antimicrobial resistance in Clostridioides difficile

Current opinion in microbiology, 2022-04, Vol.66, p.63-72

2022

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Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

Nature communications, 2023-07, Vol.14 (1), p.4130-4130, Article 4130

2023

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Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics

Journal of antibiotics, 2017-01, Vol.70 (1), p.65-72

2017

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Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review

Current topics in medicinal chemistry, 2014-01, Vol.14 (1), p.152

2014

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Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing

Microbiology spectrum, 2021-10, Vol.9 (2), p.e0044821-e0044821

2021

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Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis

PloS one, 2014-02, Vol.9 (2), p.e87909

2014

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Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases

Antimicrobial agents and chemotherapy, 2020-07, Vol.64 (8)

2020

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Bacterial persister cells tackled

Nature (London), 2018-04, Vol.556 (7699), p.40-41

2018

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Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile

Antimicrobial agents and chemotherapy, 2015-09, Vol.59 (9), p.5165-5170

2015

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In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy

Antimicrobial agents and chemotherapy, 2024-03, Vol.68 (3), p.e0122223

2024

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The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests

Journal of clinical microbiology, 2021-08, Vol.59 (9), p.e0058521-e0058521

2021

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C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation

Nature (London), 2023-10, Vol.622 (7983), p.611-618

2023

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Action of nitroheterocyclic drugs against Clostridium difficile

International journal of antimicrobial agents, 2014-10, Vol.44 (4), p.314-319

2014

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The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection

Canadian journal of microbiology, 2014-04, Vol.60 (4), p.251

2014

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Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden

Antimicrobial agents and chemotherapy, 2016-09, Vol.60 (9), p.5604-5607

2016

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The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection

Anaerobe, 2020-02, Vol.61, p.102129-102129, Article 102129

2020

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The structure–activity relationship of urea derivatives as anti-tuberculosis agents

Bioorganic & medicinal chemistry, 2011-09, Vol.19 (18), p.5585-5595

2011

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NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462

Scientific reports, 2017-09, Vol.7 (1), p.10424, Article 10424

2017

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Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation

Anaerobe, 2021-08, Vol.70, p.102387-102387, Article 102387

2021

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Solid-Phase Synthesis and Antibacterial Activity of Cyclohexapeptide Wollamide B Analogs

ACS combinatorial science, 2018-03, Vol.20 (3), p.172-185

2018

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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.166-177

2010

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The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection

ACS infectious diseases, 2019-02, Vol.5 (2), p.208-217

2019

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A simple in vitro PK/PD model system to determine time–kill curves of drugs against Mycobacteria

Tuberculosis (Edinburgh, Scotland), 2009-09, Vol.89 (5), p.378-385

2009

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Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

Mechanisms and impact of antimicrobial resistance in Clostridioides difficile

Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics

Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review

Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis

Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases

Bacterial persister cells tackled

Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile

In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy

The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests

C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation

Action of nitroheterocyclic drugs against Clostridium difficile

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux

The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection

Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden

The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection

The structure–activity relationship of urea derivatives as anti-tuberculosis agents

NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462

Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation

Solid-Phase Synthesis and Antibacterial Activity of Cyclohexapeptide Wollamide B Analogs

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection

A simple in vitro PK/PD model system to determine time–kill curves of drugs against Mycobacteria

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