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The next generation of CRISPR-Cas technologies and applications

Nature reviews. Molecular cell biology, 2019-08, Vol.20 (8), p.490-507

2019

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The once and future gene therapy

Nature communications, 2020-11, Vol.11 (1), p.5820-5820, Article 5820

2020

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A light-inducible CRISPR-Cas9 system for control of endogenous gene activation

Nature chemical biology, 2015-03, Vol.11 (3), p.198-200

2015

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ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

Trends in biotechnology (Regular ed.), 2013-07, Vol.31 (7), p.397-405

2013

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Light-Inducible Spatiotemporal Control of Gene Activation by Customizable Zinc Finger Transcription Factors

Journal of the American Chemical Society, 2012-10, Vol.134 (40), p.16480-16483

2012

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Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

Nature methods, 2015-12, Vol.12 (12), p.1143-1149

2015

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In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

Science (American Association for the Advancement of Science), 2016-01, Vol.351 (6271), p.403-407

2016

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Synthetic Zinc Finger Proteins: The Advent of Targeted Gene Regulation and Genome Modification Technologies

Accounts of chemical research, 2014-08, Vol.47 (8), p.2309-2318

2014

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RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors

Nature communications, 2018-04, Vol.9 (1), p.1674-9, Article 1674

2018

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Engineering Delivery Vehicles for Genome Editing

Annual review of chemical and biomolecular engineering, 2016-06, Vol.7 (1), p.637-662

2016

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Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells

Cell stem cell, 2016-09, Vol.19 (3), p.406-414

2016

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Loss-of-function genetic tools for animal models: cross-species and cross-platform differences

Nature reviews. Genetics, 2017-01, Vol.18 (1), p.24-40

2017

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A CRISPR/Cas9-Based System for Reprogramming Cell Lineage Specification

Stem cell reports, 2014-12, Vol.3 (6), p.940-947

2014

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Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Nature communications, 2021-11, Vol.12 (1), p.6769-12, Article 6769

2021

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Synergistic and tunable human gene activation by combinations of synthetic transcription factors

Nature methods, 2013-03, Vol.10 (3), p.239-242

2013

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Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum

Nature neuroscience, 2015-05, Vol.18 (5), p.647-656

2015

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Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage

Nucleic acids research, 2015-10, Vol.43 (18), p.8924-8941

2015

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How vinculin regulates force transmission

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (24), p.9788-9793

2013

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Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

Genome research, 2015-08, Vol.25 (8), p.1158-1169

2015

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Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes

Cell reports (Cambridge), 2019-01, Vol.26 (5), p.1174-1188.e5

2019

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Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

Nature communications, 2021-03, Vol.12 (1), p.1680-1680, Article 1680

2021

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An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Nature communications, 2019-11, Vol.10 (1), p.5012-19, Article 5012

2019

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Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2

Nucleic acids research, 2017-11, Vol.45 (20), p.e167-e167

2017

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Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding

Genome research, 2018-09, Vol.28 (9), p.1272-1284

2018

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Reading Frame Correction by Targeted Genome Editing Restores Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients

Molecular therapy, 2013-09, Vol.21 (9), p.1718-1726

2013

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The next generation of CRISPR-Cas technologies and applications

The once and future gene therapy

A light-inducible CRISPR-Cas9 system for control of endogenous gene activation

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

Light-Inducible Spatiotemporal Control of Gene Activation by Customizable Zinc Finger Transcription Factors

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

Synthetic Zinc Finger Proteins: The Advent of Targeted Gene Regulation and Genome Modification Technologies

RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors

Engineering Delivery Vehicles for Genome Editing

Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences

A CRISPR/Cas9-Based System for Reprogramming Cell Lineage Specification

Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Synergistic and tunable human gene activation by combinations of synthetic transcription factors

Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum

Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage

How vinculin regulates force transmission

Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes

Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2

Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding

Reading Frame Correction by Targeted Genome Editing Restores Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients

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