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Lung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and early reprogramming of oncogenic regulatory networks

American journal of physiology. Lung cellular and molecular physiology, 2019-12, Vol.317 (6), p.L816-L822

2019

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CYP3A‐dependent drug metabolism is reduced in bacterial inflammation in mice

British journal of pharmacology, 2012-08, Vol.166 (7), p.2176-2187

2012

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Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome

Lung, 2017-06, Vol.195 (3), p.323-332

2017

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Pentachlorophenol enhances 9-hydroxybenzo [a] pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro : likely inhibition of epoxide detoxication by pentachlorophenol

Archives of toxicology, 1996, Vol.70 (11), p.696-703

1996

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Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in rat hepatic and extrahepatic tissues

The Journal of pharmacology and experimental therapeutics, 2000-07, Vol.294 (1), p.313

Moorthy, B

2000

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Bioactivation of Polycyclic Aromatic Hydrocarbon Carcinogens within the vascular Wall: Implications for Human Atherogenesis

Drug metabolism reviews, 2005-01, Vol.37 (4), p.595-610

2005

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Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.512-519

2004

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Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain

Traffic (Copenhagen, Denmark), 2016-07, Vol.17 (7), p.754-768

2016

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3-Methylcholanthrene-inducible hepatic DNA adducts: a mechanistic hypothesis linking sequence-specific DNA adducts to sustained cytochrome P4501A1 induction by 3-methylcholanthrene

Redox report : communications in free radical research, 2002-01, Vol.7 (1), p.9-13

Moorthy, Bhagavatula

2002

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Effects of 3-Methylcholanthrene on Gene Expression Profiling in the Rat Using cDNA Microarray Analyses

Chemical research in toxicology, 2005-11, Vol.18 (11), p.1634-1641

2005

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Regulation of Pulmonary and Hepatic Cytochrome P4501A Expression in the Rat by Hyperoxia: Implications for Hyperoxic Lung Injury

Molecular pharmacology, 2002-03, Vol.61 (3), p.507-515

2002

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3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells

Biochemical and biophysical research communications, 2007-03, Vol.354 (4), p.1071-1077

2007

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I-compounds--endogenous DNA markers of nutritional status, ageing, tumour promotion and carcinogenesis

IARC scientific publications, 1993 (124), p.157

1993

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Pulegone mediated hepatotoxicity: Evidence for covalent binding of R(+)-[ 14C]pulegone to microsomal proteins in vitro

Chemico-biological interactions, 1989, Vol.72 (3), p.325-333

1989

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Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole

The Journal of pharmacology and experimental therapeutics, 2000-02, Vol.292 (2), p.553

2000

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Reciprocal post-translational regulation of renal 1 alpha- and 24-hydroxylases of 25-hydroxyvitamin D3 by phosphorylation of ferredoxin. mRNA-directed cell-free synthesis and immunoisolation of ferredoxin

Biochemical journal, 1990-03, Vol.266 (2), p.385-392

1990

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Phosphorylation of ferredoxin and regulation of renal mitochondrial 25-hydroxyvitamin D-1 α-hydroxylase activity in vitro

The Journal of biological chemistry, 1989-09, Vol.264 (26), p.15361-15366

1989

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Modulation of pulmonary cytochrome P4501A1 expression by hyperoxia and inhaled nitric oxide in the newborn rat : Implications for lung injury

Pediatric research, 2006-03, Vol.59 (3), p.401-406

2006

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Tamoxifen metabolic activation : comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo

Cancer research (Chicago, Ill.), 1996, Vol.56 (1), p.53-57

1996

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Metabolism of a monoterpene ketone, R-(+)-pulegone-a hepatotoxin in rat

Xenobiotica, 1989, Vol.19 (2), p.217-224

1989

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In situ immune complex formation in isolated perfused kidney using homologous antibody

Laboratory investigation, 1981-01, Vol.44 (1), p.1

1981

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Acetaminophen Binds to Mouse Hepatic and Renal DNA at Human Therapeutic Doses

Chemical research in toxicology, 1997-04, Vol.10 (4), p.470-476

1997

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Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity

Toxicology and applied pharmacology, 2005-02, Vol.202 (3), p.244-257

2005

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Characterization of a major aromatic DNA adduct detected in human breast tissues

Environmental and Molecular Mutagenesis, 2002, Vol.39 (2-3), p.193-200

2002

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Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo

Biochemical pharmacology, 1997-03, Vol.53 (5), p.663-669

1997

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Lung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and early reprogramming of oncogenic regulatory networks

CYP3A‐dependent drug metabolism is reduced in bacterial inflammation in mice

Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome

Pentachlorophenol enhances 9-hydroxybenzo [a] pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro : likely inhibition of epoxide detoxication by pentachlorophenol

Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in rat hepatic and extrahepatic tissues

Bioactivation of Polycyclic Aromatic Hydrocarbon Carcinogens within the vascular Wall: Implications for Human Atherogenesis

Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury

Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain

3-Methylcholanthrene-inducible hepatic DNA adducts: a mechanistic hypothesis linking sequence-specific DNA adducts to sustained cytochrome P4501A1 induction by 3-methylcholanthrene

Effects of 3-Methylcholanthrene on Gene Expression Profiling in the Rat Using cDNA Microarray Analyses

Regulation of Pulmonary and Hepatic Cytochrome P4501A Expression in the Rat by Hyperoxia: Implications for Hyperoxic Lung Injury

3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells

I-compounds--endogenous DNA markers of nutritional status, ageing, tumour promotion and carcinogenesis

Pulegone mediated hepatotoxicity: Evidence for covalent binding of R(+)-[ 14C]pulegone to microsomal proteins in vitro

Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole

Reciprocal post-translational regulation of renal 1 alpha- and 24-hydroxylases of 25-hydroxyvitamin D3 by phosphorylation of ferredoxin. mRNA-directed cell-free synthesis and immunoisolation of ferredoxin

Phosphorylation of ferredoxin and regulation of renal mitochondrial 25-hydroxyvitamin D-1 α-hydroxylase activity in vitro

Modulation of pulmonary cytochrome P4501A1 expression by hyperoxia and inhaled nitric oxide in the newborn rat : Implications for lung injury

Tamoxifen metabolic activation : comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo

Metabolism of a monoterpene ketone, R-(+)-pulegone-a hepatotoxin in rat

In situ immune complex formation in isolated perfused kidney using homologous antibody

Acetaminophen Binds to Mouse Hepatic and Renal DNA at Human Therapeutic Doses

Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity

Characterization of a major aromatic DNA adduct detected in human breast tissues

Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo

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