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Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity

Cancer research (Chicago, Ill.), 2015-09, Vol.75 (17), p.3505-3518

2015

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Efficacy and safety of Sleeping Beauty transposon-mediated gene transfer in preclinical animal studies

Current gene therapy, 2011-10, Vol.11 (5), p.341-349

2011

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CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells

Cancer research (Chicago, Ill.), 2006-11, Vol.66 (22), p.10995-11004

2006

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Dihydrofolate Reductase and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation

The Journal of biological chemistry, 2015-09, Vol.290 (38), p.22970-22976

2015

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Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system

Cancer research (Chicago, Ill.), 2008-04, Vol.68 (8), p.2961-2971

2008

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Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (38), p.14342-14346

2008

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Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

Cancer cell, 2015-05, Vol.27 (5), p.644-657

2015

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Peripheral and thymic foxp3(+) regulatory T cells in search of origin, distinction, and function

Frontiers in immunology, 2013-01, Vol.4, p.253-253

2013

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Third-party umbilical cord blood–derived regulatory T cells prevent xenogenic graft-versus-host disease

Cytotherapy (Oxford, England), 2014-01, Vol.16 (1), p.90-100

2014

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Persuading Natural Killer Cells to Eliminate Bad B Cells

Clinical cancer research, 2009-08, Vol.15 (15), p.4790-4791

Cooper, Laurence J N

2009

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Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor

Blood, 2010-08, Vol.116 (7), p.1035-1044

2010

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Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (48), p.E7788-E7797

2016

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Antigen-independent and antigen-dependent methods to numerically expand CD19-specific CD8+ T cells

Experimental hematology, 2007-07, Vol.35 (7), p.1083-1090

2007

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A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR

Blood, 2012-06, Vol.119 (24), p.5697-5705

2012

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Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells

PloS one, 2012-01, Vol.7 (1), p.e30264-e30264

2012

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Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors

Molecular therapy, 2016-07, Vol.24 (7), p.1178-1186

2016

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A Transposon and Transposase System for Human Application

Molecular therapy, 2010-04, Vol.18 (4), p.674-683

2010

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Amplification of RNAi—Targeting HLA mRNAs

Molecular therapy, 2005-05, Vol.11 (5), p.811-818

2005

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Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (29), p.10660-10665

2014

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Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

Blood, 2013-08, Vol.122 (8), p.1341-1349

2013

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Preclinical Efficacy and Safety of CD19CAR Cytokine-Induced Killer Cells Transfected with Sleeping Beauty Transposon for the Treatment of Acute Lymphoblastic Leukemia

Human gene therapy, 2018-05, Vol.29 (5), p.602-613

2018

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Haploidentical Hematopoietic Stem Cell Transplantation as a Platform for Post-Transplantation Cellular Therapy

Biology of blood and marrow transplantation, 2015-10, Vol.21 (10), p.1714-1720

2015

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Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity

PloS one, 2013-10, Vol.8 (10), p.e76781-e76781

2013

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Reprogramming CD19-Specific T Cells with IL-21 Signaling Can Improve Adoptive Immunotherapy of B-Lineage Malignancies

Cancer research (Chicago, Ill.), 2011-05, Vol.71 (10), p.3516-3527

2011

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Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity

Efficacy and safety of Sleeping Beauty transposon-mediated gene transfer in preclinical animal studies

CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells

Dihydrofolate Reductase and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation

Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system

Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

Peripheral and thymic foxp3(+) regulatory T cells in search of origin, distinction, and function

Third-party umbilical cord blood–derived regulatory T cells prevent xenogenic graft-versus-host disease

Persuading Natural Killer Cells to Eliminate Bad B Cells

Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

Antigen-independent and antigen-dependent methods to numerically expand CD19-specific CD8+ T cells

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR

Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells

Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors

A Transposon and Transposase System for Human Application

Phase 1 studies of central memory–derived CD19 CAR T–cell therapy following autologous HSCT in patients with B-cell NHL

Amplification of RNAi—Targeting HLA mRNAs

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

Preclinical Efficacy and Safety of CD19CAR Cytokine-Induced Killer Cells Transfected with Sleeping Beauty Transposon for the Treatment of Acute Lymphoblastic Leukemia

Haploidentical Hematopoietic Stem Cell Transplantation as a Platform for Post-Transplantation Cellular Therapy

Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity

Reprogramming CD19-Specific T Cells with IL-21 Signaling Can Improve Adoptive Immunotherapy of B-Lineage Malignancies

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