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Parallel artificial membrane permeability assay (PAMPA) - Is it better than Caco-2 for human passive permeability prediction?

Mini reviews in medicinal chemistry, 2010-10, Vol.10 (11), p.1071-1076

2010

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Prediction of Liquid–Liquid Phase Separation at the Dissolving Drug Salt Particle Surface

Molecular pharmaceutics, 2023-06, Vol.20 (6), p.3140-3149

2023

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Practical Approach to Modeling the Impact of Amorphous Drug Nanoparticles on the Oral Absorption of Poorly Soluble Drugs

Molecular pharmaceutics, 2020-01, Vol.17 (1), p.180-189

2020

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Designing a Novel Coamorphous Salt Formulation of Telmisartan with Amlodipine to Enhance Permeability and Oral Absorption

Molecular pharmaceutics, 2023-08, Vol.20 (8), p.4071-4085

2023

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Effect of Mechanical Agitation on Cationic Liposome Transport across an Unstirred Water Layer in Caco-2 Cells

Biological and Pharmaceutical Bulletin, 2016/08/01, Vol.39(8), pp.1293-1299

2016

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An Openable Artificial Intestinal Tract System Enables the Evaluation of Drug Absorption in Caco-2 Cells through the Reduction in Thickness of the Unstirred Water Layer

Biological and Pharmaceutical Bulletin, 2019/05/01, Vol.42(5), pp.840-844

2019

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The Solubility–Permeability Interplay: Mechanistic Modeling and Predictive Application of the Impact of Micellar Solubilization on Intestinal Permeation

Molecular pharmaceutics, 2011-10, Vol.8 (5), p.1848-1856

2011

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The Solubility–Permeability Interplay When Using Cosolvents for Solubilization: Revising the Way We Use Solubility-Enabling Formulations

Molecular pharmaceutics, 2012-03, Vol.9 (3), p.581-590

2012

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Toward Successful Cyclodextrin Based Solubility-Enabling Formulations for Oral Delivery of Lipophilic Drugs: Solubility–Permeability Trade-Off, Biorelevant Dissolution, and the Unstirred Water Layer

Molecular pharmaceutics, 2017-06, Vol.14 (6), p.2138-2146

2017

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Methacrylate-Copolymer Eudragit EPO as a Solubility-Enabling Excipient for Anionic Drugs: Investigation of Drug Solubility, Intestinal Permeability, and Their Interplay

Molecular pharmaceutics, 2019-07, Vol.16 (7), p.2884-2891

2019

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Importance of the unstirred water layer and hepatocyte membrane integrity in vitro for quantification of intrinsic metabolic clearance

Drug metabolism and disposition, 2018-03, Vol.46 (3), p.268-278

2018

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Impact of Drug-Rich Colloids of Itraconazole and HPMCAS on Membrane Flux in Vitro and Oral Bioavailability in Rats

Molecular pharmaceutics, 2017-07, Vol.14 (7), p.2437-2449

2017

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Quantitative Investigation of Intestinal Drug Absorption Enhancement by Drug-Rich Nanodroplets Generated via Liquid–Liquid Phase Separation

Molecular pharmaceutics, 2024-04, Vol.21 (4), p.1745-1755

2024

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Dose-Dependent Solubility-Permeability Interplay for Poorly Soluble Drugs under Non-Sink Conditions

Pharmaceutics, 2021-03, Vol.13 (3), p.323

2021

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Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia

Molecular pharmaceutics, 2021-02, Vol.18 (2), p.743-750

2021

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Non-Effective Improvement of Absorption for Some Nanoparticle Formulations Explained by Permeability under Non-Sink Conditions

Pharmaceutics, 2022-04, Vol.14 (4), p.816

2022

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Understanding peroral absorption: regulatory aspects and contemporary approaches to tackling solubility and permeability hurdles

Acta pharmaceutica Sinica. B, 2017-05, Vol.7 (3), p.260-280

2017

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P-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrile

Drug metabolism and disposition, 2006-09, Vol.34 (9), p.1468-1479

2006

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Comparisons of in Vitro Models to Evaluate the Membrane Permeability of Amorphous Drug Nanoparticles

Molecular pharmaceutics, 2022-09, Vol.19 (9), p.3412-3428

2022

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Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray

Antibiotics (Basel), 2017-09, Vol.6 (3), p.17

2017

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Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review

Drug metabolism reviews, 2023-07, Vol.55 (3), p.205-238

2023

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The Solubility–Permeability Interplay and Its Implications in Formulation Design and Development for Poorly Soluble Drugs

The AAPS journal, 2012-06, Vol.14 (2), p.244-251

2012

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Commercially Available Cell-Free Permeability Tests for Industrial Drug Development: Increased Sustainability through Reduction of In Vivo Studies

Pharmaceutics, 2023-02, Vol.15 (2), p.592

2023

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Crystalline Nanosuspensions as Potential Toxicology and Clinical Oral Formulations for BCS II/IV Compounds

The AAPS journal, 2012-12, Vol.14 (4), p.677-687

2012

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Drug Nanocrystals in Oral Absorption: Factors That Influence Pharmacokinetics

Pharmaceutics, 2024-08, Vol.16 (9), p.1141

2024

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Parallel artificial membrane permeability assay (PAMPA) - Is it better than Caco-2 for human passive permeability prediction?

Prediction of Liquid–Liquid Phase Separation at the Dissolving Drug Salt Particle Surface

Practical Approach to Modeling the Impact of Amorphous Drug Nanoparticles on the Oral Absorption of Poorly Soluble Drugs

Designing a Novel Coamorphous Salt Formulation of Telmisartan with Amlodipine to Enhance Permeability and Oral Absorption

Effect of Mechanical Agitation on Cationic Liposome Transport across an Unstirred Water Layer in Caco-2 Cells

An Openable Artificial Intestinal Tract System Enables the Evaluation of Drug Absorption in Caco-2 Cells through the Reduction in Thickness of the Unstirred Water Layer

The Solubility–Permeability Interplay: Mechanistic Modeling and Predictive Application of the Impact of Micellar Solubilization on Intestinal Permeation

The Solubility–Permeability Interplay When Using Cosolvents for Solubilization: Revising the Way We Use Solubility-Enabling Formulations

Toward Successful Cyclodextrin Based Solubility-Enabling Formulations for Oral Delivery of Lipophilic Drugs: Solubility–Permeability Trade-Off, Biorelevant Dissolution, and the Unstirred Water Layer

Methacrylate-Copolymer Eudragit EPO as a Solubility-Enabling Excipient for Anionic Drugs: Investigation of Drug Solubility, Intestinal Permeability, and Their Interplay

Importance of the unstirred water layer and hepatocyte membrane integrity in vitro for quantification of intrinsic metabolic clearance

Impact of Drug-Rich Colloids of Itraconazole and HPMCAS on Membrane Flux in Vitro and Oral Bioavailability in Rats

Quantitative Investigation of Intestinal Drug Absorption Enhancement by Drug-Rich Nanodroplets Generated via Liquid–Liquid Phase Separation

Dose-Dependent Solubility-Permeability Interplay for Poorly Soluble Drugs under Non-Sink Conditions

Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia

Non-Effective Improvement of Absorption for Some Nanoparticle Formulations Explained by Permeability under Non-Sink Conditions

Understanding peroral absorption: regulatory aspects and contemporary approaches to tackling solubility and permeability hurdles

P-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrile

Comparisons of in Vitro Models to Evaluate the Membrane Permeability of Amorphous Drug Nanoparticles

Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray

Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review

The Solubility–Permeability Interplay and Its Implications in Formulation Design and Development for Poorly Soluble Drugs

Commercially Available Cell-Free Permeability Tests for Industrial Drug Development: Increased Sustainability through Reduction of In Vivo Studies

Crystalline Nanosuspensions as Potential Toxicology and Clinical Oral Formulations for BCS II/IV Compounds

Drug Nanocrystals in Oral Absorption: Factors That Influence Pharmacokinetics

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