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Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses

European journal of medicinal chemistry, 2024-05, Vol.271, p.116412-116412, Article 116412

2024

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Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy

European journal of medicinal chemistry, 2024-04, Vol.269, p.116302-116302, Article 116302

2024

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Recent advances of honokiol：pharmacological activities, manmade derivatives and structure-activity relationship

European journal of medicinal chemistry, 2024-06, Vol.272, p.116471-116471, Article 116471

2024

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Perspectives and challenges in developing small molecules targeting purine nucleoside phosphorylase

European journal of medicinal chemistry, 2024-05, Vol.271, p.116437-116437, Article 116437

2024

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Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships

European journal of medicinal chemistry, 2024-05, Vol.271, p.116357-116357, Article 116357

2024

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Quinazolines annelated at the N(3)–C(4) bond: Synthesis and biological activity

European journal of medicinal chemistry, 2024-05, Vol.271, p.116411-116411, Article 116411

2024

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Synthesis and biological evaluation of 1-phenyl-tetrahydro-β-carboline-based first dual PRMT5/EGFR inhibitors as potential anticancer agents

European journal of medicinal chemistry, 2024-04, Vol.269, p.116341-116341, Article 116341

2024

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Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation

European journal of medicinal chemistry, 2024-04, Vol.269, p.116323-116323, Article 116323

2024

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Novel natural osthole-inspired amphiphiles as membrane targeting antibacterials against methicillin-resistant Staphylococcus aureus (MRSA)

European journal of medicinal chemistry, 2024-05, Vol.271, p.116449-116449, Article 116449

2024

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Discovery of N-(4-((6-(3,5- Dimethoxyphenyl)-9H-purine derivatives as irreversible covalent FGFR inhibitors

European journal of medicinal chemistry, 2024-05, Vol.271, p.116415-116415, Article 116415

2024

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Discovery of novel ocotillol derivatives modulating glucocorticoid receptor/NF-κB signaling for the treatment of sepsis

European journal of medicinal chemistry, 2024-05, Vol.271, p.116427-116427, Article 116427

2024

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Analogues of the Pan-Selectin Antagonist Rivipansel (GMI-1070)

European journal of medicinal chemistry, 2024-06, Vol.272, p.116455-116455, Article 116455

2024

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Tetrazole derivatives in the management of neurological disorders: Recent advances on synthesis and pharmacological aspects

European journal of medicinal chemistry, 2024-05, Vol.271, p.116388-116388, Article 116388

2024

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Data-oriented protein kinase drug discovery

European journal of medicinal chemistry, 2024-05, Vol.271, p.116413-116413, Article 116413

2024

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Structure-activity relationship in NOD2 agonistic muramyl dipeptides

European journal of medicinal chemistry, 2024-05, Vol.271, p.116439-116439, Article 116439

2024

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Proline-derived quinoline formamide compounds as human urate transporter 1 inhibitors with potent uric acid-lowering activities

European journal of medicinal chemistry, 2024-04, Vol.269, p.116327-116327, Article 116327

2024

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Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases

European journal of medicinal chemistry, 2024-04, Vol.269, p.116292-116292, Article 116292

2024

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Inhibitory interactions of the 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one scaffold with Bunyavirales cap-snatching endonucleases expose relevant drug design features

European journal of medicinal chemistry, 2024-06, Vol.272, p.116467-116467, Article 116467

2024

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An oleanic acid decorated gold nanorod for highly efficient inhibition of hemagglutinin and visible rapid detection of the influenza virus

European journal of medicinal chemistry, 2024-06, Vol.272, p.116469-116469, Article 116469

2024

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Novel angiogenesis inhibitors with superoxide anion radical amplification effect: Surmounting the Achilles' heels of angiogenesis inhibitors and photosensitizers

European journal of medicinal chemistry, 2024-06, Vol.272, p.116495-116495

2024

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Antiviral drug discovery: Pyrimidine entry inhibitors for Zika and dengue viruses

European journal of medicinal chemistry, 2024-06, Vol.272, p.116465-116465, Article 116465

2024

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Recent advances in c-Met-based dual inhibitors in the treatment of cancers

European journal of medicinal chemistry, 2024-06, Vol.272, p.116477-116477, Article 116477

2024

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Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors

European journal of medicinal chemistry, 2024-05, Vol.271, p.116443-116443, Article 116443

2024

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Arginine and tryptophan-rich dendritic antimicrobial peptides that disrupt membranes for bacterial infection in vivo

European journal of medicinal chemistry, 2024-05, Vol.271, p.116451-116451, Article 116451

2024

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Identification of a new bisindolinone arresting IGROV1 cells proliferation

European journal of medicinal chemistry, 2024-05, Vol.271, p.116365-116365, Article 116365

2024

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Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses

Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy

Recent advances of honokiol：pharmacological activities, manmade derivatives and structure-activity relationship

Perspectives and challenges in developing small molecules targeting purine nucleoside phosphorylase

Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships

Quinazolines annelated at the N(3)–C(4) bond: Synthesis and biological activity

Synthesis and biological evaluation of 1-phenyl-tetrahydro-β-carboline-based first dual PRMT5/EGFR inhibitors as potential anticancer agents

Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation

Novel natural osthole-inspired amphiphiles as membrane targeting antibacterials against methicillin-resistant Staphylococcus aureus (MRSA)

Discovery of N-(4-((6-(3,5- Dimethoxyphenyl)-9H-purine derivatives as irreversible covalent FGFR inhibitors

Discovery of novel ocotillol derivatives modulating glucocorticoid receptor/NF-κB signaling for the treatment of sepsis

Analogues of the Pan-Selectin Antagonist Rivipansel (GMI-1070)

Tetrazole derivatives in the management of neurological disorders: Recent advances on synthesis and pharmacological aspects

Data-oriented protein kinase drug discovery

Structure-activity relationship in NOD2 agonistic muramyl dipeptides

Proline-derived quinoline formamide compounds as human urate transporter 1 inhibitors with potent uric acid-lowering activities

Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases

Inhibitory interactions of the 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one scaffold with Bunyavirales cap-snatching endonucleases expose relevant drug design features

An oleanic acid decorated gold nanorod for highly efficient inhibition of hemagglutinin and visible rapid detection of the influenza virus

Novel angiogenesis inhibitors with superoxide anion radical amplification effect: Surmounting the Achilles' heels of angiogenesis inhibitors and photosensitizers

Antiviral drug discovery: Pyrimidine entry inhibitors for Zika and dengue viruses

Recent advances in c-Met-based dual inhibitors in the treatment of cancers

Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors

Arginine and tryptophan-rich dendritic antimicrobial peptides that disrupt membranes for bacterial infection in vivo

Identification of a new bisindolinone arresting IGROV1 cells proliferation

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