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Cellular senescence and the skeleton: pathophysiology and therapeutic implications

The Journal of clinical investigation, 2022-02, Vol.132 (3), p.1-9

2022

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Identification of Senescent Cells in the Bone Microenvironment

Journal of bone and mineral research, 2016-11, Vol.31 (11), p.1920-1929

2016

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Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice

Journal of periodontology (1970), 2021-10, Vol.92 (10), p.1483-1495

2021

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Periodontal Disease and Senescent Cells: New Players for an Old Oral Health Problem?

International journal of molecular sciences, 2020-10, Vol.21 (20), p.7441

2020

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The role of senolytics in osteoporosis and other skeletal pathologies

Mechanisms of ageing and development, 2021-10, Vol.199, p.111565-111565, Article 111565

2021

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Sympathetic β1-adrenergic signaling contributes to regulation of human bone metabolism

The Journal of clinical investigation, 2018-11, Vol.128 (11), p.4832-4842

2018

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Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing

PloS one, 2015-09, Vol.10 (9), p.e0138347-e0138347

2015

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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

The Journal of clinical investigation, 2023-04, Vol.133 (8), p.1-16

2023

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Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans

Bone (New York, N.Y.), 2014-02, Vol.59, p.1-6

2014

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Regulation of Bone Metabolism by Sex Steroids

Cold Spring Harbor perspectives in medicine, 2018-01, Vol.8 (1), p.a031211

2018

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Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration

PloS one, 2019-01, Vol.14 (1), p.e0210301-e0210301

2019

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Effects of Estrogen on Bone mRNA Levels of Sclerostin and Other Genes Relevant to Bone Metabolism in Postmenopausal Women

The journal of clinical endocrinology and metabolism, 2014-01, Vol.99 (1), p.E81-E88

2014

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Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus

Nature reviews. Endocrinology, 2021-11, Vol.17 (11), p.685-697

2021

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TIEG and estrogen modulate SOST expression in the murine skeleton

Journal of cellular physiology, 2018-04, Vol.233 (4), p.3540-3551

2018

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Estrogen and the skeleton

Trends in endocrinology and metabolism, 2012-11, Vol.23 (11), p.576-581

2012

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MicroRNA‐19a‐3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence

JBMR plus, 2023-06, Vol.7 (6), p.e10745-n/a

2023

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Relationship of Sympathetic Activity to Bone Microstructure, Turnover, and Plasma Osteopontin Levels in Women

The journal of clinical endocrinology and metabolism, 2012-11, Vol.97 (11), p.4219-4227

2012

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Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women

Bone (New York, N.Y.), 2015-07, Vol.76, p.49-57

2015

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Update on Wnt signaling in bone cell biology and bone disease

Gene, 2012-01, Vol.492 (1), p.1-18

2012

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Modest Effects of Osteoclast‐Specific ERα Deletion after Skeletal Maturity

JBMR plus, 2023-10, Vol.7 (10), p.e10797-e10797

2023

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LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis

Bone (New York, N.Y.), 2020-03, Vol.132, p.115220-115220, Article 115220

2020

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miRNAs in osteoclast biology

Bone (New York, N.Y.), 2021-02, Vol.143, p.115757-115757, Article 115757

2021

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Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Journal of bone and mineral research, 2019-08, Vol.34 (8), p.1407-1418

2019

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Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy‐Related Bone Loss

Journal of bone and mineral research, 2020-06, Vol.35 (6), p.1119-1131

2020

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TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro

Molecular and Cellular Biology, 2005-02, Vol.25 (3), p.1191-1199

2005

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Cellular senescence and the skeleton: pathophysiology and therapeutic implications

Identification of Senescent Cells in the Bone Microenvironment

Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice

Periodontal Disease and Senescent Cells: New Players for an Old Oral Health Problem?

The role of senolytics in osteoporosis and other skeletal pathologies

Sympathetic β1-adrenergic signaling contributes to regulation of human bone metabolism

Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans

Regulation of Bone Metabolism by Sex Steroids

Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration

Effects of Estrogen on Bone mRNA Levels of Sclerostin and Other Genes Relevant to Bone Metabolism in Postmenopausal Women

Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus

TIEG and estrogen modulate SOST expression in the murine skeleton

Estrogen and the skeleton

MicroRNA‐19a‐3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence

Relationship of Sympathetic Activity to Bone Microstructure, Turnover, and Plasma Osteopontin Levels in Women

Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women

Update on Wnt signaling in bone cell biology and bone disease

Modest Effects of Osteoclast‐Specific ERα Deletion after Skeletal Maturity

LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis

miRNAs in osteoclast biology

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy‐Related Bone Loss

TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro

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