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In Silico Assisted Identification, Synthesis, and In Vitro Pharmacological Characterization of Potent and Selective Blockers of the Epilepsy-Associated KCNT1 Channel

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.9124-9149

2024

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Ion channels as drug targets in central nervous system disorders

Current medicinal chemistry, 2013-04, Vol.20 (10), p.1241-1285

2013

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Tuning Photochromic Ion Channel Blockers

ACS chemical neuroscience, 2011-09, Vol.2 (9), p.536-543

2011

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Synthetic ShK-like Peptide from the Jellyfish Nemopilema nomurai Has Human Voltage-Gated Potassium-Channel-Blocking Activity

Marine drugs, 2024-05, Vol.22 (5), p.217

2024

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Marine Toxins Targeting Kv1 Channels: Pharmacological Tools and Therapeutic Scaffolds

Marine drugs, 2020-03, Vol.18 (3), p.173

2020

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Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes

Marine drugs, 2020-08, Vol.18 (8), p.425

2020

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Medicinal Chemistry of hERG Optimizations: Highlights and Hang-Ups

Journal of medicinal chemistry, 2006-08, Vol.49 (17), p.5029-5046

2006

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Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents

Bioorganic & medicinal chemistry letters, 2019-05, Vol.29 (10), p.1241-1245

2019

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Acredinones A and B, Voltage-Dependent Potassium Channel Inhibitors from the Sponge-Derived Fungus Acremonium sp. F9A015

Journal of natural products (Washington, D.C.), 2015-03, Vol.78 (3), p.363-367

2015

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Discovery of an Inhibitor for the TREK‑1 Channel Targeting an Intermediate Transition State of Channel Gating

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.10972-10983

2020

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BK channel modulators: a comprehensive overview

Current medicinal chemistry, 2008-05, Vol.15 (11), p.1126-1146

2008

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Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2497-2511

2016

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Selective I Kur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5‑[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide

Journal of medicinal chemistry, 2017-05, Vol.60 (9), p.3795-3803

2017

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Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574

Journal of chemical information and modeling, 2020-01, Vol.60 (1), p.360-371

2020

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A binary QSAR model for classification of hERG potassium channel blockers

Bioorganic & medicinal chemistry, 2008-04, Vol.16 (7), p.4107-4119

2008

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Selective Small Molecule Activators of TREK‑2 Channels Stimulate Dorsal Root Ganglion c‑Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx

ACS chemical neuroscience, 2017-03, Vol.8 (3), p.558-568

2017

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General Purpose 2D and 3D Similarity Approach to Identify hERG Blockers

Journal of chemical information and modeling, 2016-01, Vol.56 (1), p.213-222

2016

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Myrsinane, Premyrsinane, and Cyclomyrsinane Diterpenes from Euphorbia falcata as Potassium Ion Channel Inhibitors with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effects

Journal of natural products (Washington, D.C.), 2016-08, Vol.79 (8), p.1990-2004

2016

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A Rational Design of a Selective Inhibitor for Kv1.1 Channels Prevalent in Demyelinated Nerves That Improves Their Impaired Axonal Conduction

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2245-2256

2017

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AbeTx1 Is a Novel Sea Anemone Toxin with a Dual Mechanism of Action on Shaker-Type K⁺ Channels Activation

Marine drugs, 2018-10, Vol.16 (10), p.360

2018

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Discovery of a Teraryl Oxazolidinone Compound (S)‑N‑((3-(3-Fluoro-4-(4-(pyridin-2-yl)‑1H‑pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies

Journal of medicinal chemistry, 2015-08, Vol.58 (16), p.6389

2015

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Optical Control of a Delayed Rectifier and a Two-Pore Potassium Channel with a Photoswitchable Bupivacaine

ACS chemical neuroscience, 2018-12, Vol.9 (12), p.2886-2891

2018

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Enhancement of voltage-gated K+ channels and depression of voltage-gated Ca2+ channels are involved in quercetin-induced vasorelaxation in rat coronary artery

Planta medica, 2014-04, Vol.80 (6), p.465-472

2014

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Elucidation of the possible mechanism of analgesic action of methanol stem bark extract of Uapaca togoensis pax in mice

Journal of ethnopharmacology, 2019-12, Vol.245, p.112156-112156, Article 112156

2019

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Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure

In Silico Assisted Identification, Synthesis, and In Vitro Pharmacological Characterization of Potent and Selective Blockers of the Epilepsy-Associated KCNT1 Channel

Ion channels as drug targets in central nervous system disorders

Tuning Photochromic Ion Channel Blockers

Synthetic ShK-like Peptide from the Jellyfish Nemopilema nomurai Has Human Voltage-Gated Potassium-Channel-Blocking Activity

Marine Toxins Targeting Kv1 Channels: Pharmacological Tools and Therapeutic Scaffolds

Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes

Medicinal Chemistry of hERG Optimizations: Highlights and Hang-Ups

Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents

Acredinones A and B, Voltage-Dependent Potassium Channel Inhibitors from the Sponge-Derived Fungus Acremonium sp. F9A015

Discovery of an Inhibitor for the TREK‑1 Channel Targeting an Intermediate Transition State of Channel Gating

BK channel modulators: a comprehensive overview

Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties

Selective I Kur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5‑[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide

Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574

A binary QSAR model for classification of hERG potassium channel blockers

Selective Small Molecule Activators of TREK‑2 Channels Stimulate Dorsal Root Ganglion c‑Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx

General Purpose 2D and 3D Similarity Approach to Identify hERG Blockers

Myrsinane, Premyrsinane, and Cyclomyrsinane Diterpenes from Euphorbia falcata as Potassium Ion Channel Inhibitors with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effects

A Rational Design of a Selective Inhibitor for Kv1.1 Channels Prevalent in Demyelinated Nerves That Improves Their Impaired Axonal Conduction

AbeTx1 Is a Novel Sea Anemone Toxin with a Dual Mechanism of Action on Shaker-Type K⁺ Channels Activation

Discovery of a Teraryl Oxazolidinone Compound (S)‑N‑((3-(3-Fluoro-4-(4-(pyridin-2-yl)‑1H‑pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies

Optical Control of a Delayed Rectifier and a Two-Pore Potassium Channel with a Photoswitchable Bupivacaine

Enhancement of voltage-gated K+ channels and depression of voltage-gated Ca2+ channels are involved in quercetin-induced vasorelaxation in rat coronary artery

Elucidation of the possible mechanism of analgesic action of methanol stem bark extract of Uapaca togoensis pax in mice

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