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From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity

Bioorganic & medicinal chemistry, 2021-07, Vol.42, p.116266-116266, Article 116266

2021

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Design, synthesis and antitumor activity of novel thiophene- triazine derivatives bearing arylurea unit as potent PI3K/mTOR inhibitorss

Bioorganic & medicinal chemistry, 2023-01, Vol.78, p.117133, Article 117133

2023

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Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy

Bioorganic & medicinal chemistry, 2017-08, Vol.25 (15), p.4100-4109

2017

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VEGFR-2 inhibiting effect and molecular modeling of newly synthesized coumarin derivatives as anti-breast cancer agents

Bioorganic & medicinal chemistry, 2020-03, Vol.28 (5), p.115328, Article 115328

2020

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Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents

Bioorganic & medicinal chemistry, 2010-05, Vol.18 (10), p.3543-3550

2010

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Design, synthesis, and biological evaluation of quinoxalinone derivatives as potent BRD4 inhibitors

Bioorganic & medicinal chemistry, 2023-01, Vol.78, p.117152, Article 117152

2023

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Design and synthesis of new coumarin hybrids and insight into their mode of antiproliferative action

Bioorganic & medicinal chemistry, 2017-02, Vol.25 (3), p.1066-1075

2017

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Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models

Bioorganic & medicinal chemistry, 2021-05, Vol.37, p.116097-116097, Article 116097

2021

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Design, synthesis and biological evaluation of indoline-maleimide conjugates as potential antitumor agents for the treatment of colorectal cancer

Bioorganic & medicinal chemistry, 2024-06, Vol.108, p.117786, Article 117786

2024

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Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential

Bioorganic & medicinal chemistry, 2021-11, Vol.50, p.116453, Article 116453

2021

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Triptonide induces apoptosis and inhibits the proliferation of ovarian cancer cells by activating the p38/p53 pathway and autophagy

Bioorganic & medicinal chemistry, 2024-08, Vol.110, p.117788, Article 117788

2024

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Design, synthesis and biological evaluation of 4,6-diarylquinoxaline-based KDM4D inhibitors

Bioorganic & medicinal chemistry, 2024-11, Vol.114, p.117945, Article 117945

2024

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Novel naphthoquinone-1H-1,2,3-triazole hybrids: Design, synthesis and evaluation as inductors of ROS-mediated apoptosis in the MCF-7 cells

Bioorganic & medicinal chemistry, 2024-03, Vol.102, p.117671-117671, Article 117671

2024

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Design, synthesis, and antitumor activity evaluation of novel acyl sulfonamide spirodienones

Bioorganic & medicinal chemistry, 2022-04, Vol.60, p.116626-116626, Article 116626

2022

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Novel inhibitors of bromodomain and extra-terminal domain trigger cell death in breast cancer cell lines

Bioorganic & medicinal chemistry, 2024-10, Vol.112, p.117884, Article 117884

2024

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Design, synthesis and biological evaluation of novel pyrazinone derivatives as PI3K/HDAC dual inhibitors

Bioorganic & medicinal chemistry, 2022-11, Vol.74, p.117067-117067, Article 117067

2022

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Photodynamic anticancer activity evaluation of novel 5-aminolevulinic acid and 3-hydroxypyridinone conjugates

Bioorganic & medicinal chemistry, 2024-05, Vol.105, p.117726-117726, Article 117726

2024

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Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies

Bioorganic & medicinal chemistry, 2021-09, Vol.46, p.116384-116384, Article 116384

2021

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Design, synthesis, and biological evaluation of novel 1-amido-2-one-4-thio-deoxypyranose as potential antitumor agents for multiple myeloma

Bioorganic & medicinal chemistry, 2024-09, Vol.111, p.117843, Article 117843

2024

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Progress in the development of small molecular inhibitors of the Bruton’s tyrosine kinase (BTK) as a promising cancer therapy

Bioorganic & medicinal chemistry, 2021-10, Vol.47, p.116358-116358, Article 116358

2021

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Design, synthesis, and biological evaluation of 2-(naphthalen-1-yloxy)-N-phenylacetamide derivatives as TRPM4 inhibitors for the treatment of prostate cancer

Bioorganic & medicinal chemistry, 2024-01, Vol.98, p.117584-117584, Article 117584

2024

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Synthesis, biological activity and mechanism of action of novel allosecurinine derivatives as potential antitumor agents

Bioorganic & medicinal chemistry, 2023-03, Vol.82, p.117234-117234, Article 117234

2023

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Novel gold-based complex GC7 suppresses cancer cell proliferation via impacting energy metabolism mediated by mitochondria

Bioorganic & medicinal chemistry, 2024-10, Vol.112, p.117897, Article 117897

2024

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Synthesis and evaluation of novel tetrahydroisoquinoline-benzo[h]chromen-4-one conjugates as dual ABCB1/CYP1B1 inhibitors for overcoming MDR in cancer

Bioorganic & medicinal chemistry, 2024-11, Vol.114, p.117944, Article 117944

2024

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Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents

Bioorganic & medicinal chemistry, 2014-04, Vol.22 (7), p.2060-2079

2014

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From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity

Design, synthesis and antitumor activity of novel thiophene- triazine derivatives bearing arylurea unit as potent PI3K/mTOR inhibitorss

Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy

VEGFR-2 inhibiting effect and molecular modeling of newly synthesized coumarin derivatives as anti-breast cancer agents

Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents

Design, synthesis, and biological evaluation of quinoxalinone derivatives as potent BRD4 inhibitors

Design and synthesis of new coumarin hybrids and insight into their mode of antiproliferative action

Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models

Design, synthesis and biological evaluation of indoline-maleimide conjugates as potential antitumor agents for the treatment of colorectal cancer

Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential

Triptonide induces apoptosis and inhibits the proliferation of ovarian cancer cells by activating the p38/p53 pathway and autophagy

Design, synthesis and biological evaluation of 4,6-diarylquinoxaline-based KDM4D inhibitors

Novel naphthoquinone-1H-1,2,3-triazole hybrids: Design, synthesis and evaluation as inductors of ROS-mediated apoptosis in the MCF-7 cells

Design, synthesis, and antitumor activity evaluation of novel acyl sulfonamide spirodienones

Novel inhibitors of bromodomain and extra-terminal domain trigger cell death in breast cancer cell lines

Design, synthesis and biological evaluation of novel pyrazinone derivatives as PI3K/HDAC dual inhibitors

Photodynamic anticancer activity evaluation of novel 5-aminolevulinic acid and 3-hydroxypyridinone conjugates

Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies

Design, synthesis, and biological evaluation of novel 1-amido-2-one-4-thio-deoxypyranose as potential antitumor agents for multiple myeloma

Progress in the development of small molecular inhibitors of the Bruton’s tyrosine kinase (BTK) as a promising cancer therapy

Design, synthesis, and biological evaluation of 2-(naphthalen-1-yloxy)-N-phenylacetamide derivatives as TRPM4 inhibitors for the treatment of prostate cancer

Synthesis, biological activity and mechanism of action of novel allosecurinine derivatives as potential antitumor agents

Novel gold-based complex GC7 suppresses cancer cell proliferation via impacting energy metabolism mediated by mitochondria

Synthesis and evaluation of novel tetrahydroisoquinoline-benzo[h]chromen-4-one conjugates as dual ABCB1/CYP1B1 inhibitors for overcoming MDR in cancer

Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents

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