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Tongxinluo (TXL), a Traditional Chinese Medicinal Compound, Improves Endothelial Function After Chronic Hypoxia Both In Vivo and In Vitro

Journal of cardiovascular pharmacology, 2015-06, Vol.65 (6), p.579-586

2015

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Tongxinluo may stabilize atherosclerotic plaque via multiple mechanisms scanning by genechip

Biomedicine & pharmacotherapy, 2019-05, Vol.113, p.108767-108767, Article 108767

2019

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Chinese medicine Tongxinluo reduces atherosclerotic lesion by attenuating oxidative stress and inflammation in microvascular endothelial cells

International journal of clinical and experimental pathology, 2015-01, Vol.8 (6), p.6323-6333

2015

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The protective role of Tongxinluo on blood–brain barrier after ischemia–reperfusion brain injury

Journal of ethnopharmacology, 2013-07, Vol.148 (2), p.632-639

2013

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A case of advanced gastric cancer effectively treated by combined chemotherapy of paclitaxel (TXL) and CDDP

Gan to kagaku ryoho, 2004-04, Vol.31 (4), p.585

2004

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Protective effects of Tongxinluo on cerebral ischemia/reperfusion injury related to Connexin 43/Calpain II/Bax/Caspase-3 pathway in rat

Journal of ethnopharmacology, 2017-02, Vol.198, p.148-157

2017

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Tongxinluo attenuates reperfusion injury in diabetic hearts by angiopoietin-like 4-mediated protection of endothelial barrier integrity via PPAR-α pathway

PloS one, 2018-06, Vol.13 (6), p.e0198403-e0198403

2018

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A patient with advanced gastric cancer that response remarkably to combination chemotherapy of TS-1 and biweekly paclitaxel (TXL)

Gan to kagaku ryoho, 2003-09, Vol.30 (9), p.1347

2003

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Tongxinluo exerts protective effects via anti‐apoptotic and pro‐autophagic mechanisms by activating AMPK pathway in infarcted rat hearts

Experimental physiology, 2017-04, Vol.102 (4), p.422-435

2017

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The protective effect of melatonin supplementation against taxol-induced testicular cytotoxicity in adult rats

Brazilian journal of medical and biological research, 2022-01, Vol.55 (1), p.e11614-e11614

2022

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A case of advanced gastric cancer showing pylorus stenosis with multiple liver metastases, that respond remarkably to neoadjuvant chemotherapy of combined TXL and low-dose FP

Gan to kagaku ryoho, 2003-03, Vol.30 (3), p.407

2003

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Tongxinluo reduces brain edema and inhibits post-ischemic inflammation after middle cerebral artery occlusion in rats

Journal of ethnopharmacology, 2016-04, Vol.181, p.136-145

2016

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Effect of Tongxinluo on pulmonary hypertension and pulmonary vascular remodeling in rats exposed to a low pressure hypoxic environment

Journal of ethnopharmacology, 2016-12, Vol.194, p.668-673

2016

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Chinese medicine Tongxinluo increases tight junction protein levels by inducing KLF5 expression in microvascular endothelial cells

Cell biochemistry and function, 2015-06, Vol.33 (4), p.226-234

2015

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PI3K/Akt pathway contributes to neuroprotective effect of Tongxinluo against focal cerebral ischemia and reperfusion injury in rats

Journal of ethnopharmacology, 2016-04, Vol.181, p.8-19

2016

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Tongxinluo protects against pressure overload-induced heart failure in mice involving VEGF/Akt/eNOS pathway activation

PloS one, 2014-06, Vol.9 (6), p.e98047-e98047

2014

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Effects of tongxinluo on the neointima formation and expression of inflammatory cytokines in rats after carotid artery balloon injury

Indian journal of pharmacology, 2014-09, Vol.46 (5), p.510-514

2014

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Neuroprotective effects of Tongxinluo on focal cerebral ischemia and reperfusion injury in rats associated with the activation of the MEK1/2/ERK1/2/p90RSK signaling pathway

Brain research, 2018-04, Vol.1685, p.9-18

2018

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Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: a comparison with a high-dose simvastatin therapy

American journal of physiology. Heart and circulatory physiology, 2009-12, Vol.297 (6), p.H2004-H2014

2009

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Effects of tongxinluo on angiogenesis in the carotid adventitia of hyperlipidemic rabbits

Molecular medicine reports, 2016-10, Vol.14 (4), p.3832-3840

2016

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Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blockade of the positive feedback loop between miR-155 and TNF-α

American journal of physiology. Heart and circulatory physiology, 2014-08, Vol.307 (4), p.H552-H562

2014

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Combination therapy induces unfolded protein response and cytoskeletal rearrangement leading to mitochondrial apoptosis in prostate cancer

Molecular oncology, 2016-08, Vol.10 (7), p.949-965

2016

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Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction

Biomedicine & pharmacotherapy, 2022-01, Vol.145, p.112367-112367, Article 112367

2022

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Tongxinluo promotes mesenchymal stem cell tube formation in vitro

Journal of Zhejiang University. B. Science, 2011-08, Vol.12 (8), p.644-651

2011

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Tongxinluo Induces nNOS Expression Through ERK Activation: Possible Contribution to the Effects of Tongxinluo to Attenuate Vasoconstriction

Journal of cardiovascular pharmacology, 2015-07, Vol.66 (1), p.9-15

2015

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Tongxinluo (TXL), a Traditional Chinese Medicinal Compound, Improves Endothelial Function After Chronic Hypoxia Both In Vivo and In Vitro

Tongxinluo may stabilize atherosclerotic plaque via multiple mechanisms scanning by genechip

Chinese medicine Tongxinluo reduces atherosclerotic lesion by attenuating oxidative stress and inflammation in microvascular endothelial cells

The protective role of Tongxinluo on blood–brain barrier after ischemia–reperfusion brain injury

A case of advanced gastric cancer effectively treated by combined chemotherapy of paclitaxel (TXL) and CDDP

Protective effects of Tongxinluo on cerebral ischemia/reperfusion injury related to Connexin 43/Calpain II/Bax/Caspase-3 pathway in rat

Tongxinluo attenuates reperfusion injury in diabetic hearts by angiopoietin-like 4-mediated protection of endothelial barrier integrity via PPAR-α pathway

A patient with advanced gastric cancer that response remarkably to combination chemotherapy of TS-1 and biweekly paclitaxel (TXL)

Tongxinluo exerts protective effects via anti‐apoptotic and pro‐autophagic mechanisms by activating AMPK pathway in infarcted rat hearts

The protective effect of melatonin supplementation against taxol-induced testicular cytotoxicity in adult rats

A case of advanced gastric cancer showing pylorus stenosis with multiple liver metastases, that respond remarkably to neoadjuvant chemotherapy of combined TXL and low-dose FP

Tongxinluo reduces brain edema and inhibits post-ischemic inflammation after middle cerebral artery occlusion in rats

Effect of Tongxinluo on pulmonary hypertension and pulmonary vascular remodeling in rats exposed to a low pressure hypoxic environment

Chinese medicine Tongxinluo increases tight junction protein levels by inducing KLF5 expression in microvascular endothelial cells

PI3K/Akt pathway contributes to neuroprotective effect of Tongxinluo against focal cerebral ischemia and reperfusion injury in rats

Tongxinluo protects against pressure overload-induced heart failure in mice involving VEGF/Akt/eNOS pathway activation

Effects of tongxinluo on the neointima formation and expression of inflammatory cytokines in rats after carotid artery balloon injury

Neuroprotective effects of Tongxinluo on focal cerebral ischemia and reperfusion injury in rats associated with the activation of the MEK1/2/ERK1/2/p90RSK signaling pathway

Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: a comparison with a high-dose simvastatin therapy

Effects of tongxinluo on angiogenesis in the carotid adventitia of hyperlipidemic rabbits

Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blockade of the positive feedback loop between miR-155 and TNF-α

Combination therapy induces unfolded protein response and cytoskeletal rearrangement leading to mitochondrial apoptosis in prostate cancer

Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction

Tongxinluo promotes mesenchymal stem cell tube formation in vitro

Tongxinluo Induces nNOS Expression Through ERK Activation: Possible Contribution to the Effects of Tongxinluo to Attenuate Vasoconstriction

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