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A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

Nature communications, 2018-08, Vol.9 (1), p.3165-14, Article 3165

2018

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MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

Journal of allergy and clinical immunology, 2015-08, Vol.136 (2), p.462-473

2015

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Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

ACS chemical biology, 2017-03, Vol.12 (3), p.825-832

2017

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Insights into the Interaction between Immobilized Biocatalysts and Metal–Organic Frameworks: A Case Study of PCN-333

JACS Au, 2021-12, Vol.1 (12), p.2172-2181

2021

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Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A

Journal of allergy and clinical immunology, 2014-06, Vol.133 (6), p.1720-1727

2014

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TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis

BMC pulmonary medicine, 2019-02, Vol.19 (1), p.31-11, Article 31

2019

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A fluorescent assay for ceramide synthase activity

Journal of lipid research, 2012-08, Vol.53 (8), p.1701-1707

2012

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Use of modulators and light to control crystallisation of a hydrogen bonded framework

Chemical communications (Cambridge, England), 2021-12, Vol.58 (2), p.36-39

2021

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Development of novel PP2A activators for use in the treatment of acute myeloid leukaemia

Organic & biomolecular chemistry, 2016-01, Vol.14 (20), p.4605-4616

2016

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Tumor necrosis factor-related apoptosis-inducing ligand regulates hallmark features of airways remodeling in allergic airways disease

American journal of respiratory cell and molecular biology, 2014-07, Vol.51 (1), p.86-93

2014

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Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors

Organic & biomolecular chemistry, 2015-12, Vol.13 (48), p.11593-11596

2015

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Shwachman-Bodian-Diamond syndrome activity and overexpressed in acute myeloid leukaemia

Leukemia, 2020-12, Vol.34 (12), p.3393

2020

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Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitorsElectronic supplementary information (ESI) available: Synthetic procedures and characterisation data for all new compounds. See DOI: 10.1039/c5ob01931a

2015-12

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Development of novel PP2A activators for use in the treatment of acute myeloid leukaemiaElectronic supplementary information (ESI) available: Synthetic procedures and characterisation data for all new compounds. See DOI: 10.1039/c6ob00556j

2016-05

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Concise Total Synthesis of Dioncophylline E through an ortho‐Arylation Strategy

Angewandte Chemie, 2017-07, Vol.129 (29), p.8656-8658

2017

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Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

Oncotarget, 2016-07, Vol.7 (30), p.47465-47478

2016

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A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

Insights into the Interaction between Immobilized Biocatalysts and Metal–Organic Frameworks: A Case Study of PCN-333

Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A

TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis

A fluorescent assay for ceramide synthase activity

Use of modulators and light to control crystallisation of a hydrogen bonded framework

Shwachman-Bodian-Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia

Development of novel PP2A activators for use in the treatment of acute myeloid leukaemia

Tumor necrosis factor-related apoptosis-inducing ligand regulates hallmark features of airways remodeling in allergic airways disease

Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors

Shwachman-Bodian-Diamond syndrome activity and overexpressed in acute myeloid leukaemia

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitorsElectronic supplementary information (ESI) available: Synthetic procedures and characterisation data for all new compounds. See DOI: 10.1039/c5ob01931a

Development of novel PP2A activators for use in the treatment of acute myeloid leukaemiaElectronic supplementary information (ESI) available: Synthetic procedures and characterisation data for all new compounds. See DOI: 10.1039/c6ob00556j

Concise Total Synthesis of Dioncophylline E through an ortho‐Arylation Strategy

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

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