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NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

Clinical science (1979), 2016-03, Vol.130 (5), p.317-335

2016

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MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension

PloS one, 2016-05, Vol.11 (5), p.e0153780-e0153780

2016

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Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension

Hypertension (Dallas, Tex. 1979), 2020-10, Vol.76 (4), p.1208-1218

2020

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Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors

Current pharmaceutical design, 2015-01, Vol.21 (41), p.6023-6035

2015

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Nox and Inflammation in the Vascular Adventitia

Hypertension (Dallas, Tex. 1979), 2016-01, Vol.67 (1), p.14-19

2016

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The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls

Antioxidants & redox signaling, 2014-06, Vol.20 (17), p.2741-2754

2014

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Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation

Clinical science (1979), 2017-08, Vol.131 (15), p.2019-2035

2017

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Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo

Clinical science (1979), 2024-05, Vol.138 (10), p.573-597

2024

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The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1

Science signaling, 2017-10, Vol.10 (501)

2017

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The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors

Biochemical journal, 2021-06, Vol.478 (11), p.2059-2079

2021

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Of Mouse and Man: Cross-Species Characterization of Hypertensive Cardiac Remodeling

International journal of molecular sciences, 2022-07, Vol.23 (14), p.7709

2022

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The cardiomyocyte “redox rheostat”: Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death

Journal of molecular and cellular cardiology, 2019-04, Vol.129, p.118-129

2019

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Deficiency in SIRP‐α cytoplasmic recruitment confers protection from acute kidney injury

The FASEB journal, 2019-10, Vol.33 (10), p.11528-11540

2019

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The impact of the cytoplasmic ubiquitin ligase TNFAIP3 gene variation on transcription factor NF-κB activation in acute kidney injury

Kidney international, 2023-06, Vol.103 (6), p.1105-1119

2023

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Vascular Collagen Type-IV in Hypertension and Cerebral Small Vessel Disease

Stroke (1970), 2022-12, Vol.53 (12), p.3696-3705

2022

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MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins

Biochemical journal, 2021-06, Vol.478 (11), p.2121-2143

2021

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CD47 and Nox1 Mediate Dynamic Fluid-Phase Macropinocytosis of Native LDL

Antioxidants & redox signaling, 2017-06, Vol.26 (16), p.886-901

2017

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The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

Clinical science (1979), 2021-07, Vol.135 (14), p.1631-1647

2021

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PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses

Biochemical journal, 2022-07, Vol.479 (13), p.1467-1486

2022

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Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

Biochemical journal, 2022-02, Vol.479 (3), p.401-424

2022

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Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype

Proceedings of the National Academy of Sciences - PNAS, 2016-09, Vol.113 (36), p.E5308-E5317

2016

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Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease

JACC. Basic to translational science, 2024-05, Vol.9 (5), p.607-627

2024

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Molecular Insights of p47phox Phosphorylation Dynamics in the Regulation of NADPH Oxidase Activation and Superoxide Production

The Journal of biological chemistry, 2014-08, Vol.289 (33), p.22759-22770

2014

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BS8 RAF ‘paradox breaker’ PLX8394 activates ERK1/2 VIA craf, with no effect on angii-induced cardiac remodelling in mice

Heart (British Cardiac Society), 2022-06, Vol.108 (Suppl 1), p.A148-A148

2022

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BS33 The RAF ‘paradox breaker’ inhibitor, PLX8394, activates ERK1/2 in endothelial cells and promotes cardiac remodelling

Heart (British Cardiac Society), 2021-06, Vol.107 (Suppl 1), p.A174-A174

2021

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NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension

Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension

Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors

Nox and Inflammation in the Vascular Adventitia

The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls

Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation

Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo

The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1

The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors

Of Mouse and Man: Cross-Species Characterization of Hypertensive Cardiac Remodeling

The cardiomyocyte “redox rheostat”: Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death

Deficiency in SIRP‐α cytoplasmic recruitment confers protection from acute kidney injury

The impact of the cytoplasmic ubiquitin ligase TNFAIP3 gene variation on transcription factor NF-κB activation in acute kidney injury

Vascular Collagen Type-IV in Hypertension and Cerebral Small Vessel Disease

MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins

CD47 and Nox1 Mediate Dynamic Fluid-Phase Macropinocytosis of Native LDL

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype

Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease

Molecular Insights of p47phox Phosphorylation Dynamics in the Regulation of NADPH Oxidase Activation and Superoxide Production

BS8 RAF ‘paradox breaker’ PLX8394 activates ERK1/2 VIA craf, with no effect on angii-induced cardiac remodelling in mice

BS33 The RAF ‘paradox breaker’ inhibitor, PLX8394, activates ERK1/2 in endothelial cells and promotes cardiac remodelling

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