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R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

The Journal of experimental medicine, 2017-12, Vol.214 (12), p.3507-3518

2017

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Targeted delivery to macrophages and dendritic cells by chemically modified mannose ligand-conjugated siRNA

Nucleic acids research, 2022-05, Vol.50 (9), p.4840-4859

2022

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The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells

The Journal of experimental medicine, 2011-02, Vol.208 (2), p.285-294

2011

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R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

Human molecular genetics, 2008-05, Vol.17 (9), p.1278-1291

2008

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Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium

Science (American Association for the Advancement of Science), 2005-08, Vol.309 (5738), p.1256-1259

2005

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Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism

American journal of physiology. Renal physiology, 2005-11, Vol.289 (5), p.F1088-F1095

2005

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Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency

Molecular therapy. Nucleic acids, 2023-09, Vol.33, p.391-403

2023

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Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans

Human molecular genetics, 2013-02, Vol.22 (3), p.578-592

2013

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R-Spondin Proteins: A Novel Link to β-catenin Activation

Cell cycle (Georgetown, Tex.), 2006-01, Vol.5 (1), p.23-26

2006

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Craniofacial malformation in R-spondin2 knockout mice

Biochemical and biophysical research communications, 2009-04, Vol.381 (3), p.453-458

2009

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Adult-specific systemic over-expression reveals novel in vivo effects of the soluble forms of ActRIIA, ActRIIB and BMPRII

PloS one, 2013-10, Vol.8 (10), p.e78076-e78076

2013

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Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling

Molecular therapy. Nucleic acids, 2021-03, Vol.23, p.629-639

2021

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Identification of osteoblast stimulating factor 5 as a negative regulator in the B-lymphopoietic niche

Experimental hematology, 2015-11, Vol.43 (11), p.963-973.e4

2015

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Development and evaluation of a novel antibody-photon absorber conjugate reveals the possibility of photoimmunotherapy-induced vascular occlusion during treatment in vivo

Oncotarget, 2018-07, Vol.9 (59), p.31422-31431

2018

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The Infantile Leukoencephalopathy-Associated Mutation of C11ORF73/HIKESHI Proteins Generates de novo Interactive Activity with Filamin A, Inhibiting Oligodendroglial Cell Morphological Differentiation

Medicines (Basel, Switzerland), 2021-02, Vol.8 (2), p.9

2021

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Functional redundancy of the Notch gene family during mouse embryogenesis: Analysis of Notch gene expression in Notch3-deficient mice

Biochemical and biophysical research communications, 2005-06, Vol.331 (4), p.1154-1162

2005

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A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells

Biochemical and biophysical research communications, 2011-11, Vol.415 (3), p.439-444

2011

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Double Trans-Chromosomic Mice: Maintenance of Two Individual Human Chromosome Fragments Containing Ig Heavy and κ Loci and Expression of Fully Human Antibodies

Proceedings of the National Academy of Sciences - PNAS, 2000-01, Vol.97 (2), p.722-727

2000

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Novel anticarcinoembryonic antigen antibody–drug conjugate has antitumor activity in the existence of soluble antigen

Cancer medicine (Malden, MA), 2017-04, Vol.6 (4), p.798-808

2017

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novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region

Transgenic research, 2014-06, Vol.23 (3), p.441-453

2014

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Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome (HAC) vector

Biochemical and biophysical research communications, 2008-05, Vol.369 (3), p.807-811

2008

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Rapid human genomic DNA cloning into mouse artificial chromosome via direct chromosome transfer from human iPSC and CRISPR/Cas9-mediated translocation

Nucleic acids research, 2024-02, Vol.52 (3), p.1498-1511

2024

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Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

The Journal of clinical investigation, 2004-02, Vol.113 (4), p.561-568

2004

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Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand–siRNA Conjugates

ACS chemical biology, 2022-02, Vol.17 (2), p.292-298

2022

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S2B1-1 Nobel approaches to facilitate the genome-based discovery of drug targets and the development of human antiboby therapeutics

Journal of Pharmacological Sciences, 2008, Vol.106 (suppl.1), p.27-27

Kazuma Tomizuka

2008

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R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

Targeted delivery to macrophages and dendritic cells by chemically modified mannose ligand-conjugated siRNA

The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium

Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism

Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans

R-Spondin Proteins: A Novel Link to β-catenin Activation

Craniofacial malformation in R-spondin2 knockout mice

Adult-specific systemic over-expression reveals novel in vivo effects of the soluble forms of ActRIIA, ActRIIB and BMPRII

Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling

Identification of osteoblast stimulating factor 5 as a negative regulator in the B-lymphopoietic niche

Development and evaluation of a novel antibody-photon absorber conjugate reveals the possibility of photoimmunotherapy-induced vascular occlusion during treatment in vivo

The Infantile Leukoencephalopathy-Associated Mutation of C11ORF73/HIKESHI Proteins Generates de novo Interactive Activity with Filamin A, Inhibiting Oligodendroglial Cell Morphological Differentiation

Functional redundancy of the Notch gene family during mouse embryogenesis: Analysis of Notch gene expression in Notch3-deficient mice

A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells

Double Trans-Chromosomic Mice: Maintenance of Two Individual Human Chromosome Fragments Containing Ig Heavy and κ Loci and Expression of Fully Human Antibodies

Novel anticarcinoembryonic antigen antibody–drug conjugate has antitumor activity in the existence of soluble antigen

novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region

Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome (HAC) vector

Rapid human genomic DNA cloning into mouse artificial chromosome via direct chromosome transfer from human iPSC and CRISPR/Cas9-mediated translocation

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand–siRNA Conjugates

S2B1-1 Nobel approaches to facilitate the genome-based discovery of drug targets and the development of human antiboby therapeutics

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