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Morphine metabolism, transport and brain disposition

Metabolic brain disease, 2012-03, Vol.27 (1), p.1-5

2012

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Age-and Region-Dependent Disposition of Raloxifene in Rats

Pharmaceutical research, 2021-08, Vol.38 (8), p.1357-1367

2021

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Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

Journal of pharmacokinetics and pharmacodynamics, 2012-02, Vol.39 (1), p.67-86

2012

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A translational platform PBPK model for antibody disposition in the brain

Journal of pharmacokinetics and pharmacodynamics, 2019-08, Vol.46 (4), p.319-338

2019

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Sinusoidal Organic Anion-Transporting Polypeptide 1B1/1B3 and Bile Canalicular Multidrug Resistance-Associated Protein 2 Play an Essential Role in the Hepatobiliary Disposition of a Synthetic Cyclic Dinucleotide (STING Agonist)

The AAPS journal, 2022-09, Vol.24 (6), p.99, Article 99

2022

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Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Pharmaceutical research, 2014-08, Vol.31 (8), p.2203-2219

2014

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Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Pharmaceutical research, 2023-11, Vol.40 (11), p.2513-2523

2023

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Pharmacokinetic Modeling of the Impact of P-glycoprotein on Ondansetron Disposition in the Central Nervous System

Pharmaceutical research, 2020-10, Vol.37 (10), p.205-205, Article 205

2020

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Metabolism and Disposition of the Novel Oral Factor XIa Inhibitor Asundexian in Rats and in Humans

European journal of drug metabolism and pharmacokinetics, 2023-07, Vol.48 (4), p.411-425

2023

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Translational CNS Steady-State Drug Disposition Model in Rats, Monkeys, and Humans for Quantitative Prediction of Brain-to-Plasma and Cerebrospinal Fluid-to-Plasma Unbound Concentration Ratios

The AAPS journal, 2021-06, Vol.23 (4), p.81-81, Article 81

2021

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Acyclovir Brain Disposition: Interactions with P-gp, Bcrp, Mrp2, and Oat3 at the Blood–Brain Barrier

European journal of drug metabolism and pharmacokinetics, 2022-03, Vol.47 (2), p.279-289

2022

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Mechanisms responsible for poor oral bioavailability of paeoniflorin : Role of intestinal disposition and interactions with sinomenine

Pharmaceutical research, 2006-12, Vol.23 (12), p.2768-2780

2006

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Co-administration of Selenium with Inorganic Mercury Alters the Disposition of Mercuric Ions in Rats

Biological trace element research, 2020-05, Vol.195 (1), p.187-195

2020

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Characterization of the Stereoselective Disposition of Bupropion and Its Metabolites in Rat Plasma and Brain

European journal of drug metabolism and pharmacokinetics, 2023-03, Vol.48 (2), p.171-187

2023

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Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human

Cancer chemotherapy and pharmacology, 2016, Vol.77 (1), p.43-62

2016

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Dual Physiologically Based Pharmacokinetic Model of Liposomal and Nonliposomal Amphotericin B Disposition

Pharmaceutical research, 2014-01, Vol.31 (1), p.35-45

2014

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Paclitaxel Prodrugs with Sustained Release and High Solubility in Poly(ethylene glycol)-b-poly(ε-caprolactone) Micelle Nanocarriers: Pharmacokinetic Disposition, Tolerability, and Cytotoxicity

Pharmaceutical research, 2008-01, Vol.25 (1), p.194-206

2008

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FG-3019, a Human Monoclonal Antibody Recognizing Connective Tissue Growth Factor, is Subject to Target-Mediated Drug Disposition

Pharmaceutical research, 2016-08, Vol.33 (8), p.1833-1849

2016

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Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences

The AAPS journal, 2011-09, Vol.13 (3), p.378, Article 378

2011

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Comparison of Intestinal Absorption and Disposition of Structurally Similar Bioactive Flavones in Radix Scutellariae

The AAPS journal, 2012-03, Vol.14 (1), p.23-34

2012

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Breast Cancer Resistance Protein (BCRP) and Sulfotransferases Contribute Significantly to the Disposition of Genistein in Mouse Intestine

The AAPS journal, 2010-12, Vol.12 (4), p.525-536

2010

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Brain Disposition and Catalepsy After Intranasal Delivery of Loxapine: Role of Metabolism in PK/PD of Intranasal CNS Drugs

Pharmaceutical research, 2013-09, Vol.30 (9), p.2368-2384

2013

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The effect of increased lipoproteins levels on the disposition of vincristine in rat

Lipids in health and disease, 2016-09, Vol.15 (1), p.152, Article 152

2016

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Single- and multiple-dose disposition kinetics of sunitinib malate, a multitargeted receptor tyrosine kinase inhibitor: comparative plasma kinetics in non-clinical species

Cancer chemotherapy and pharmacology, 2009-09, Vol.64 (4), p.691-706

2009

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P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide

Pharmaceutical research, 2004-07, Vol.21 (7), p.1294-1302

2004

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Morphine metabolism, transport and brain disposition

Age-and Region-Dependent Disposition of Raloxifene in Rats

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

A translational platform PBPK model for antibody disposition in the brain

Sinusoidal Organic Anion-Transporting Polypeptide 1B1/1B3 and Bile Canalicular Multidrug Resistance-Associated Protein 2 Play an Essential Role in the Hepatobiliary Disposition of a Synthetic Cyclic Dinucleotide (STING Agonist)

Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Pharmacokinetic Modeling of the Impact of P-glycoprotein on Ondansetron Disposition in the Central Nervous System

Metabolism and Disposition of the Novel Oral Factor XIa Inhibitor Asundexian in Rats and in Humans

Translational CNS Steady-State Drug Disposition Model in Rats, Monkeys, and Humans for Quantitative Prediction of Brain-to-Plasma and Cerebrospinal Fluid-to-Plasma Unbound Concentration Ratios

Acyclovir Brain Disposition: Interactions with P-gp, Bcrp, Mrp2, and Oat3 at the Blood–Brain Barrier

Mechanisms responsible for poor oral bioavailability of paeoniflorin : Role of intestinal disposition and interactions with sinomenine

Co-administration of Selenium with Inorganic Mercury Alters the Disposition of Mercuric Ions in Rats

Characterization of the Stereoselective Disposition of Bupropion and Its Metabolites in Rat Plasma and Brain

Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human

Dual Physiologically Based Pharmacokinetic Model of Liposomal and Nonliposomal Amphotericin B Disposition

Paclitaxel Prodrugs with Sustained Release and High Solubility in Poly(ethylene glycol)-b-poly(ε-caprolactone) Micelle Nanocarriers: Pharmacokinetic Disposition, Tolerability, and Cytotoxicity

FG-3019, a Human Monoclonal Antibody Recognizing Connective Tissue Growth Factor, is Subject to Target-Mediated Drug Disposition

Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences

Comparison of Intestinal Absorption and Disposition of Structurally Similar Bioactive Flavones in Radix Scutellariae

Breast Cancer Resistance Protein (BCRP) and Sulfotransferases Contribute Significantly to the Disposition of Genistein in Mouse Intestine

Brain Disposition and Catalepsy After Intranasal Delivery of Loxapine: Role of Metabolism in PK/PD of Intranasal CNS Drugs

The effect of increased lipoproteins levels on the disposition of vincristine in rat

Single- and multiple-dose disposition kinetics of sunitinib malate, a multitargeted receptor tyrosine kinase inhibitor: comparative plasma kinetics in non-clinical species

P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide

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