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Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection

Xenobiotica, 2022-11, Vol.52 (9-11), p.973-985

2022

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Morphine metabolism, transport and brain disposition

Metabolic brain disease, 2012-03, Vol.27 (1), p.1-5

2012

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Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans

Acta pharmacologica Sinica, 2022-02, Vol.43 (2), p.494-503

2022

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Metabolism and disposition of [14C]tivantinib after oral administration to humans, dogs and rats

Xenobiotica, 2014-11, Vol.44 (11), p.996-1008

2014

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Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

Journal of pharmacokinetics and pharmacodynamics, 2012-02, Vol.39 (1), p.67-86

2012

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Age-and Region-Dependent Disposition of Raloxifene in Rats

Pharmaceutical research, 2021-08, Vol.38 (8), p.1357-1367

2021

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Deferiprone ameliorates memory impairment in Scopolamine-treated rats: The impact of its iron-chelating effect on β-amyloid disposition

Behavioural brain research, 2020-01, Vol.378, p.112314, Article 112314

2020

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Metabolic disposition of the anti-cancer agent [14C]laromustine in male rats

Xenobiotica, 2015-08, Vol.45 (8), p.711-721

2015

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A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models

CPT: pharmacometrics and systems pharmacology, 2023-03, Vol.12 (3), p.346-359

2023

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Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species

Acta pharmacologica Sinica, 2018-06, Vol.39 (6), p.1048-1063

2018

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Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin‐drug interactions

Phytotherapy research, 2021-06, Vol.35 (6), p.3286-3297

2021

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A translational platform PBPK model for antibody disposition in the brain

Journal of pharmacokinetics and pharmacodynamics, 2019-08, Vol.46 (4), p.319-338

2019

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Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules

European journal of pharmaceutical sciences, 2023-09, Vol.188, p.106481-106481, Article 106481

2023

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Disposition of β-N-methylamino-l-alanine (L-BMAA), a neurotoxin, in rodents following a single or repeated oral exposure

Toxicology and applied pharmacology, 2018-01, Vol.339, p.151-160

2018

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PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy

International journal of pharmaceutics, 2011-06, Vol.412 (1), p.132-141

2011

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Preclinical pharmacokinetics, disposition, and translational pharmacokinetic/pharmacodynamic modeling of savolitinib, a novel selective cMet inhibitor

European journal of pharmaceutical sciences, 2019-08, Vol.136, p.104938, Article 104938

2019

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In-vivo disposition characteristics of PEG niosome and its interaction with serum proteins

International journal of pharmaceutics, 2016-10, Vol.512 (1), p.322-328

2016

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Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Pharmaceutical research, 2014-08, Vol.31 (8), p.2203-2219

2014

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Pharmacokinetic Modeling of the Impact of P-glycoprotein on Ondansetron Disposition in the Central Nervous System

Pharmaceutical research, 2020-10, Vol.37 (10), p.205-205, Article 205

2020

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In vitro disposition profiling of heterocyclic compounds

International journal of pharmaceutics, 2015-08, Vol.491 (1-2), p.78-90

2015

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Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Pharmaceutical research, 2023-11, Vol.40 (11), p.2513-2523

2023

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Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration

Toxicology and applied pharmacology, 2019-09, Vol.378, p.114592-114592, Article 114592

2019

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Metabolism and disposition of the SGLT2 inhibitor bexagliflozin in rats, monkeys and humans

Xenobiotica, 2020-05, Vol.50 (5), p.559-569

2020

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Aging and the disposition and toxicity of mercury in rats

Experimental gerontology, 2014-05, Vol.53, p.31-39

2014

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Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells

Xenobiotica, 2020-08, Vol.50 (8), p.997-1008

2020

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Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection

Morphine metabolism, transport and brain disposition

Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans

Metabolism and disposition of [14C]tivantinib after oral administration to humans, dogs and rats

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

Age-and Region-Dependent Disposition of Raloxifene in Rats

Deferiprone ameliorates memory impairment in Scopolamine-treated rats: The impact of its iron-chelating effect on β-amyloid disposition

Metabolic disposition of the anti-cancer agent [14C]laromustine in male rats

A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models

Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species

Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin‐drug interactions

A translational platform PBPK model for antibody disposition in the brain

Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules

Disposition of β-N-methylamino-l-alanine (L-BMAA), a neurotoxin, in rodents following a single or repeated oral exposure

PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy

Preclinical pharmacokinetics, disposition, and translational pharmacokinetic/pharmacodynamic modeling of savolitinib, a novel selective cMet inhibitor

In-vivo disposition characteristics of PEG niosome and its interaction with serum proteins

Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Pharmacokinetic Modeling of the Impact of P-glycoprotein on Ondansetron Disposition in the Central Nervous System

In vitro disposition profiling of heterocyclic compounds

Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration

Metabolism and disposition of the SGLT2 inhibitor bexagliflozin in rats, monkeys and humans

Aging and the disposition and toxicity of mercury in rats

Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells

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