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Improving the predictive power of xenograft and syngeneic anti-tumour studies using mice humanised for pathways of drug metabolism [version 2; peer review: 2 approved]

F1000 research, 2022-01, Vol.11, p.1081-1081

2022

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Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies [version 2; peer review: 2 approved]

F1000 research, 2022-01, Vol.11, p.1164-1164

2022

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No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARδ and PPARγ act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma

Pharmacogenetics and genomics, 2005-10, Vol.15 (10), p.713-721

2005

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Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Toxicology and applied pharmacology, 2019-03, Vol.366, p.64-74

2019

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Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

British journal of cancer, 2017-08, Vol.117 (5), p.e1-e1

2017

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Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo

PPAR Research, 2012-01, Vol.2012 (2012), p.1-12

2012

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Pharmacogenetics

BMJ. British medical journal (International ed.), 2000-04, Vol.320 (7240), p.987

International edition, 2000

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The application of knockout and humanized models to study human pathways of anti-cancer drug metabolism

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S6-S7

2017

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Removal notice to “Non-catalytic mechanisms involved in glutathione S-transferase Pi mediated cytoprotection” [Toxicology 290 (2011) 130]

Toxicology (Amsterdam), 2012-12, Vol.302 (2), p.321-321

2012

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Recombinant DNA technology as an investigative tool in drug metabolism research

Advanced drug delivery reviews, 1996-11, Vol.22 (1), p.187-213

1996

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Cytochrome b ₅ null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

Transgenic research, 2011-06, Vol.20 (3), p.491-502

2011

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Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi

Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (49), p.20859-20864

2009

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Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

Expert review of clinical pharmacology, 2009-03, Vol.2 (2), p.105-109

2009

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Abstract 2933: Application of a mouse model humanized for the major pathways of drug disposition in anticancer drug development and use

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2933-2933

2019

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MOLECULAR MECHANISM OF GENOTOXICITY OF THE ENVIRONMENTAL POLLUTANT 3-NITROBENZANTHRONE

Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia, 2005-12, Vol.149 (2), p.191-197

2005

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Xenobiotic receptor humanized mice and their utility: Nuclear Receptor

Drug metabolism reviews, 2013, Vol.45 (1), p.110-121

2013

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Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Toxicology and applied pharmacology, 2019-03, Vol.366, p.64-74

2019

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Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice

Archives of toxicology, 2018, Vol.92 (4), p.1625-1638

2018

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Olaparib, alone or in combination with ionizing radiation, exacerbates DNA damage in normal tissues, as revealed by a new p21 reporter mouse

Molecular cancer research, 2016-09, Vol.14 (12), p.1195-1203

2016

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The cap 'n' collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

Cancer research (Chicago, Ill.), 2001-04, Vol.61 (8), p.3299-3307

2001

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Why Is Quinidine an Inhibitor of Cytochrome P450 2D6?

The Journal of biological chemistry, 2005-11, Vol.280 (46), p.38617-38624

2005

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Evidence That Cytochrome b 5 and Cytochrome b 5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System

Molecular pharmacology, 2013-06, Vol.83 (6), p.1209-1217

2013

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Cytochrome b 5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo

Molecular pharmacology, 2015-04, Vol.87 (4), p.733-739

2015

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Improving the predictive power of xenograft and syngeneic anti-tumour studies using mice humanised for pathways of drug metabolism [version 2; peer review: 2 approved]

Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies [version 2; peer review: 2 approved]

Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors

No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARδ and PPARγ act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo

Pharmacogenetics

The application of knockout and humanized models to study human pathways of anti-cancer drug metabolism

Removal notice to “Non-catalytic mechanisms involved in glutathione S-transferase Pi mediated cytoprotection” [Toxicology 290 (2011) 130]

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione- S -transferase π

Recombinant DNA technology as an investigative tool in drug metabolism research

Cytochrome b ₅ null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

Abstract 2933: Application of a mouse model humanized for the major pathways of drug disposition in anticancer drug development and use

MOLECULAR MECHANISM OF GENOTOXICITY OF THE ENVIRONMENTAL POLLUTANT 3-NITROBENZANTHRONE

Xenobiotic receptor humanized mice and their utility: Nuclear Receptor

Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice

Olaparib, alone or in combination with ionizing radiation, exacerbates DNA damage in normal tissues, as revealed by a new p21 reporter mouse

The cap 'n' collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

Why Is Quinidine an Inhibitor of Cytochrome P450 2D6?

Evidence That Cytochrome b 5 and Cytochrome b 5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System

Cytochrome b 5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo

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