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Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress

Cardiovascular research, 2019-10, Vol.115 (12), p.1766-1777

2019

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GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure

Cells (Basel, Switzerland), 2021-01, Vol.10 (1), p.154

2021

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Mitochondrial 4-HNE derived from MAO-A promotes mitoCa2+ overload in chronic postischemic cardiac remodeling

Cell death and differentiation, 2020-06, Vol.27 (6), p.1907-1923

2020

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Acute heart failure: mechanisms and pre-clinical models—a Scientific Statement of the ESC Working Group on Myocardial Function

Cardiovascular research, 2023-11, Vol.119 (14), p.2390-2404

2023

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Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics

Journal of computer-aided molecular design, 2020-11, Vol.34 (11), p.1171-1179

2020

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Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis

Cell reports (Cambridge), 2020-08, Vol.32 (8), p.108075-20, Article 108075

2020

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Epac Function and cAMP Scaffolds in the Heart and Lung

Journal of cardiovascular development and disease, 2018-02, Vol.5 (1), p.9

2018

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Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3β Signaling

Molecular and Cellular Biology, 2010-05, Vol.30 (10), p.2498-2507

2010

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Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist

Journal of the American Chemical Society, 2018-08, Vol.140 (30), p.9624-9637

2018

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Effectiveness and Safety of a Prolonged Hemodynamic Support by the IVAC2L System in Healthy and Cardiogenic Shock Pigs

Frontiers in cardiovascular medicine, 2022-02, Vol.9, p.809143-809143

2022

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Signaling through cAMP-Epac1 induces metabolic reprogramming to protect podocytes in glomerulonephritis

Kidney international, 2024-05

2024

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Identification of Epac1 transcriptomic signature in ventricular myocytes

Journal of molecular and cellular cardiology, 2022-12, Vol.173, p.164-164

2022

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Epac1 promotes mitochondrial dysfunction and cardiomyocyte death during persistent lipid overload

Journal of molecular and cellular cardiology, 2022-12, Vol.173, p.153-154

2022

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High Constitutive NF-kappa B Activity Mediates Resistance to Oxidative Stress in Neuronal Cells

The Journal of neuroscience, 1998-05, Vol.18 (9), p.3224-3232

1998

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The Epac1 Protein: Pharmacological Modulators, Cardiac Signalosome and Pathophysiology

Cells (Basel, Switzerland), 2019-11, Vol.8 (12), p.1543

2019

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Role of exchange protein directly activated by cAMP 1 in cardiac aging

Journal of molecular and cellular cardiology, 2022-12, Vol.173, p.94-94

2022

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PO-01-171 ROLE OF THE EXCHANGE PROTEIN ACTIVATED BY CAMP (EPAC) IN ATRIAL ELECTROPHYSIOLOGY AND ATRIAL FIBRILLATION MECHANISMS

Heart rhythm, 2023-05, Vol.20 (5), p.S152-S152

2023

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Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation

Frontiers in physiology, 2023, Vol.14, p.1120336-1120336

2023

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Nanoparticles-mediated lysosomal acidification limits doxorubicin cardiotoxicity

Journal of molecular and cellular cardiology, 2022-12, Vol.173, p.37-38

2022

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GRK and Epac1 interaction in cardiac remodelling and heart failure

Cells (Basel, Switzerland), 2021-01, Vol.10 (1)

2021

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Pharmacological Inhibition of Epac1 Averts Ferroptosis Cell Death by Preserving Mitochondrial Integrity

Antioxidants, 2022-02, Vol.11 (2), p.314

2022

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Targeting epigenetic mechanisms as an emerging therapeutic strategy in pulmonary hypertension disease

Vascular biology, 2020-01, Vol.2 (1), p.R17-R34

2020

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Pharmacological characterization of the human 5‐HT4(d) receptor splice variant stably expressed in Chinese hamster ovary cells

British journal of pharmacology, 2000-10, Vol.131 (4), p.827-835

2000

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5-HT sub(4) receptor and Alzheimer's disease: The amyloid connection

Experimental neurology, 2007-06, Vol.205 (2), p.325-329

Lezoualc'h, Frank

2007

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Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress

GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure

Mitochondrial 4-HNE derived from MAO-A promotes mitoCa2+ overload in chronic postischemic cardiac remodeling

Acute heart failure: mechanisms and pre-clinical models—a Scientific Statement of the ESC Working Group on Myocardial Function

Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics

Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis

Epac Function and cAMP Scaffolds in the Heart and Lung

Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3β Signaling

Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist

Effectiveness and Safety of a Prolonged Hemodynamic Support by the IVAC2L System in Healthy and Cardiogenic Shock Pigs

Signaling through cAMP-Epac1 induces metabolic reprogramming to protect podocytes in glomerulonephritis

Identification of Epac1 transcriptomic signature in ventricular myocytes

Epac1 promotes mitochondrial dysfunction and cardiomyocyte death during persistent lipid overload

High Constitutive NF-kappa B Activity Mediates Resistance to Oxidative Stress in Neuronal Cells

The Epac1 Protein: Pharmacological Modulators, Cardiac Signalosome and Pathophysiology

Role of exchange protein directly activated by cAMP 1 in cardiac aging

PO-01-171 ROLE OF THE EXCHANGE PROTEIN ACTIVATED BY CAMP (EPAC) IN ATRIAL ELECTROPHYSIOLOGY AND ATRIAL FIBRILLATION MECHANISMS

Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation

Nanoparticles-mediated lysosomal acidification limits doxorubicin cardiotoxicity

GRK and Epac1 interaction in cardiac remodelling and heart failure

Pharmacological Inhibition of Epac1 Averts Ferroptosis Cell Death by Preserving Mitochondrial Integrity

Targeting epigenetic mechanisms as an emerging therapeutic strategy in pulmonary hypertension disease

EPAC1 inhibition protects the heart from doxorubicin-induced toxicity

Pharmacological characterization of the human 5‐HT4(d) receptor splice variant stably expressed in Chinese hamster ovary cells

5-HT sub(4) receptor and Alzheimer's disease: The amyloid connection

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