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Altered bile acid and coproporphyrin-I disposition in patients with autosomal dominant polycystic kidney disease

British journal of clinical pharmacology, 2024-09

2024

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Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework

CPT: pharmacometrics and systems pharmacology, 2024-06

2024

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Physiologically Based Pharmacokinetic

Pharmaceutical research, 2024-03, Vol.41 (3), p.441

2024

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Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro

Frontiers in pharmacology, 2023-03, Vol.14, p.1147495-1147495

2023

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Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences

PloS one, 2022-12, Vol.17 (12), p.e0278297

2022

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Clinical Relevance of Hepatic and Renal P‐gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective

Clinical pharmacology and therapeutics, 2022-09, Vol.112 (3), p.573-592

2022

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Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

Clinical pharmacology and therapeutics, 2022-09, Vol.112 (3), p.461-484

2022

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Correction to Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer’s Disease

Molecular pharmaceutics, 2021-10, Vol.18 (10), p.3928-3929

2021

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Recent advances in drug transporter sciences: highlights from the year 2020

Drug metabolism reviews, 2021-07, Vol.53 (3), p.321-349

2021

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Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes

Frontiers in pharmacology, 2021-04, Vol.12, p.655320

2021

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E‑Cigarette Flavoring Chemicals Induce Cytotoxicity in HepG2 Cells

ACS omega, 2021-03, Vol.6 (10), p.6708-6713

2021

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A Phase 2 Study of Odronextamab (REGN1979), a CD20 x CD3 Bispecific Antibody, in Patients with Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma

Blood, 2020-11, Vol.136 (Supplement 1), p.28-29

2020

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Intestinal P-gp and Putative Hepatic OATP1B Induction: ITC Perspective on Drug Development Implications

Clinical pharmacology and therapeutics, 2020-07, Vol.109 (1), p.55-64

2020

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Intestinal Permeability and Oral Absorption of Selected Drugs Are Reduced in a Mouse Model of Familial Alzheimer’s Disease

Molecular pharmaceutics, 2020-05, Vol.17 (5), p.1527-1537

2020

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Mechanistic Modeling of the Hepatic Disposition of Estradiol-17 β -Glucuronide in Sandwich-Cultured Human Hepatocytes

Drug metabolism and disposition, 2020-02, Vol.48 (2), p.116-122

2020

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Progressive Pulmonary Artery Dilatation is Associated with Type B Aortic Dissection in Patients with Marfan Syndrome

Journal of clinical medicine, 2019-11, Vol.8 (11), p.1848

2019

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Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1222-1230

2019

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Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization

Toxicological sciences, 2019-10, Vol.171 (2), p.431-442

2019

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Novel In Vitro Method Reveals Drugs that Inhibit Solute Transporter Alpha/Beta (OSTα/β)

Molecular pharmaceutics, 2018-12, Vol.16 (1), p.238-246

2018

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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.916-932

2018

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Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO

CPT: pharmacometrics and systems pharmacology, 2018-10, Vol.7 (10), p.629-637

2018

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Transporter‐Mediated Alterations in Patients With NASH Increase Systemic and Hepatic Exposure to an OATP and MRP2 Substrate

Clinical pharmacology and therapeutics, 2018-10, Vol.104 (4), p.749-756

2018

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Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers

Anesthesiology (Philadelphia), 2018-06, Vol.128 (6), p.1107-1116

2018

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Farnesoid X Receptor Agonists Obeticholic Acid and Chenodeoxycholic Acid Increase Bile Acid Efflux in Sandwich-Cultured Human Hepatocytes: Functional Evidence and Mechanisms

The Journal of pharmacology and experimental therapeutics, 2018-05, Vol.365 (2), p.413-421

2018

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Organic solute transporter OSTa/ß is overexpressed in nonalcoholic steatohepatitis and modulated by drugs associated with liver injury

American journal of physiology: Gastrointestinal and liver physiology, 2018-05, Vol.314 (5), p.G597

2018

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Altered bile acid and coproporphyrin-I disposition in patients with autosomal dominant polycystic kidney disease

Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework

Physiologically Based Pharmacokinetic

Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro

Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences

Clinical Relevance of Hepatic and Renal P‐gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective

Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

Correction to Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer’s Disease

Recent advances in drug transporter sciences: highlights from the year 2020

Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes

E‑Cigarette Flavoring Chemicals Induce Cytotoxicity in HepG2 Cells

A Phase 2 Study of Odronextamab (REGN1979), a CD20 x CD3 Bispecific Antibody, in Patients with Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma

Intestinal P-gp and Putative Hepatic OATP1B Induction: ITC Perspective on Drug Development Implications

Intestinal Permeability and Oral Absorption of Selected Drugs Are Reduced in a Mouse Model of Familial Alzheimer’s Disease

Mechanistic Modeling of the Hepatic Disposition of Estradiol-17 β -Glucuronide in Sandwich-Cultured Human Hepatocytes

Progressive Pulmonary Artery Dilatation is Associated with Type B Aortic Dissection in Patients with Marfan Syndrome

Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions

Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization

Novel In Vitro Method Reveals Drugs that Inhibit Solute Transporter Alpha/Beta (OSTα/β)

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO

Transporter‐Mediated Alterations in Patients With NASH Increase Systemic and Hepatic Exposure to an OATP and MRP2 Substrate

Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers

Farnesoid X Receptor Agonists Obeticholic Acid and Chenodeoxycholic Acid Increase Bile Acid Efflux in Sandwich-Cultured Human Hepatocytes: Functional Evidence and Mechanisms

Organic solute transporter OSTa/ß is overexpressed in nonalcoholic steatohepatitis and modulated by drugs associated with liver injury

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