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661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

Scientific reports, 2017-12, Vol.7 (1), p.16855-13, Article 16855

2017

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Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin

Frontiers in immunology, 2018-06, Vol.9, p.1287-1287

2018

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A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

PloS one, 2015-09, Vol.10 (9), p.e0138289-e0138289

2015

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Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation

PloS one, 2011-03, Vol.6 (3), p.e17477

2011

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Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein

The Journal of biological chemistry, 2018-01, Vol.293 (1), p.132-147

2018

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E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy

PloS one, 2014-04, Vol.9 (4), p.e95758-e95758

2014

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Autophagy receptor optineurin promotes autophagosome formation by potentiating LC3-II production and phagophore maturation

Communicative & integrative biology, 2018-03, Vol.11 (2), p.1-4

2018

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A cytoprotective role for optineurin during mycobacterial infection of macrophages

Biochemistry and biophysics reports, 2024-07, Vol.38, p.101672-101672, Article 101672

2024

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Umakant Waman Kenkare (1927–2019)

Current science (Bangalore), 2020-09, Vol.119 (6), p.1055-1055

Swarup, Ghanshyam

2020

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Emerging role of tyrosine phosphatase, TCPTP, in the organelles of the early secretory pathway

Biochimica et biophysica acta, 2013-05, Vol.1833 (5), p.1125-1132

2013

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Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi

Biology of the cell, 2011-07, Vol.103 (7), p.333-350

2011

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A Glaucoma-Associated Mutant of Optineurin Selectively Induces Death of Retinal Ganglion Cells Which Is Inhibited by Antioxidants

Investigative ophthalmology & visual science, 2007-04, Vol.48 (4), p.1607-1614

2007

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Cold-induced loss of interaction with HSC70 triggers inflammasome activity of familial cold autoinflammatory syndrome-causing mutants of NLRP3

Biochemical and biophysical research communications, 2023-01, Vol.641, p.42-49

2023

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Optineurin mediates negative regulation of Rab8 function by TBC1D17, a GTPase activating protein

Journal of cell science, 2012-01

2012

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Physical and Functional Interaction between Hck Tyrosine Kinase and Guanine Nucleotide Exchange Factor C3G Results in Apoptosis, Which Is Independent of C3G Catalytic Domain

The Journal of biological chemistry, 2003-12, Vol.278 (52), p.52188-52194

2003

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HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (43), p.21694-21703

2019

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Regulation of p73 by Hck through kinase-dependent and independent mechanisms

BMC molecular biology, 2007-05, Vol.8 (1), p.45-45, Article 45

2007

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Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice

Biochimica et biophysica acta. Molecular basis of disease, 2022-10, Vol.1868 (10), p.166470-166470, Article 166470

2022

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Direct Transcriptional Activation of Human Caspase-1 by Tumor Suppressor p53

The Journal of biological chemistry, 2001-04, Vol.276 (14), p.10585-10588

2001

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Optineurin modulates ER stress-induced signaling pathways and cell death

Biochemical and biophysical research communications, 2021-01, Vol.534, p.297-302

2021

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A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death

The Journal of biological chemistry, 2017-01, Vol.292 (4), p.1218-1230

2017

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NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB

PloS one, 2009-04, Vol.4 (4), p.e5114

2009

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Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants

Progress in molecular biology and translational science, 2023, Vol.194, p.67-78

2023

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M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

Autophagy, 2013-04, Vol.9 (4), p.510-527

2013

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Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

Journal of cell science, 2012-11, Vol.125 (Pt 21), p.5026-5039

2012

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661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation

Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein

E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy

Autophagy receptor optineurin promotes autophagosome formation by potentiating LC3-II production and phagophore maturation

A cytoprotective role for optineurin during mycobacterial infection of macrophages

Umakant Waman Kenkare (1927–2019)

Emerging role of tyrosine phosphatase, TCPTP, in the organelles of the early secretory pathway

Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi

A Glaucoma-Associated Mutant of Optineurin Selectively Induces Death of Retinal Ganglion Cells Which Is Inhibited by Antioxidants

Cold-induced loss of interaction with HSC70 triggers inflammasome activity of familial cold autoinflammatory syndrome-causing mutants of NLRP3

Optineurin mediates negative regulation of Rab8 function by TBC1D17, a GTPase activating protein

Physical and Functional Interaction between Hck Tyrosine Kinase and Guanine Nucleotide Exchange Factor C3G Results in Apoptosis, Which Is Independent of C3G Catalytic Domain

HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4

Regulation of p73 by Hck through kinase-dependent and independent mechanisms

Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice

Direct Transcriptional Activation of Human Caspase-1 by Tumor Suppressor p53

Optineurin modulates ER stress-induced signaling pathways and cell death

A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death

NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB

Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

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