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Pyrimidine-fused Dinitrogenous Penta-heterocycles as a Privileged Scaffold for Anti-Cancer Drug Discovery

Current topics in medicinal chemistry, 2022-02, Vol.22 (4), p.284-304

2022

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The efficient in‐situ reduction and cyclization reaction of aromatic aldehyde, 1,3‐cyclopentanedione (tetronic acid), and nitro‐compound under SnCl2·2H2O‐THF medium

Applied organometallic chemistry, 2018-03, Vol.32 (3), p.n/a

2018

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Synthesis and in vitro anticancer activity of pyrazolo[1,5-a]pyrimidines and pyrazolo[3,4-d][1,2,3]triazines

Synthetic communications, 2017-11, Vol.47 (21), p.1963-1972

2017

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Synthesis and antimicrobial activity of some new heterocycles incorporating antipyrine moiety

European journal of medicinal chemistry, 2008-10, Vol.43 (10), p.2122-2129

2008

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Synthesis, anticancer activity and molecular docking of new pyrazolo[1,5-a]pyrimidine derivatives as EGFR/HER2 dual kinase inhibitors

Journal of molecular structure, 2023-10, Vol.1289, p.135877, Article 135877

2023

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Green synthesis of novel spiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-2,3′(7′H)- dione, spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3′-indoline]-2′,3-dione, and spiro[benzo [h]pyrazolo[3,4-b]quinoline-7,3′-indoline]-2′,8(5H)-dione derivatives in aqueous medium

Tetrahedron, 2017-01, Vol.73 (4), p.385-394

2017

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Identification of indole-grafted pyrazolopyrimidine and pyrazolopyridine derivatives as new anti-cancer agents: Synthesis, biological assessments, and molecular modeling insights

Bioorganic chemistry, 2024-12, Vol.153, p.107804, Article 107804

2024

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Cyanide chemosensors based on 3-dicyanovinylpyrazolo[1,5-a]pyrimidines: Effects of peripheral 4-anisyl group substitution on the photophysical properties

Talanta (Oxford), 2020-08, Vol.215, p.120905-120905, Article 120905

2020

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Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5689-5692

2009

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Synthesis of some novel pyrazolo[3,4- b]pyridine and pyrazolo[3,4- d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents

European journal of medicinal chemistry, 2009-11, Vol.44 (11), p.4385-4392

El-Sayed Ali, Tarik

2009

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Detrifluoromethylamination of trifluoromethyl pyrazolo[1,5-a]pyrimidins enabled by unusual C-CF3 bond cleavage

Tetrahedron, 2024-11, Vol.167, p.134216, Article 134216

2024

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Caesium carbonate supported on hydroxyapatite-encapsulated Ni0.5Zn0.5Fe2O4 nanocrystallites as a novel magnetically basic catalyst for the one-pot synthesis of pyrazolo[1,2-b]phthalazine-5,10-diones

Applied organometallic chemistry, 2015-05, Vol.29 (5), p.290-295

2015

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Stereoselective synthesis of dihydrothiadiazinoazines and dihydrothiadiazinoazoles and their pyrolytic desulfurization ring contraction

Tetrahedron, 2011-08, Vol.67 (34), p.6259-6274

2011

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Regioselective synthesis and theoretical calculations of Bis(pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines) linked to benzofuran units via piperazine spacer: A DFT, MM2, and MMFF94 study

Journal of molecular structure, 2021-11, Vol.1243, p.130802, Article 130802

2021

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Electrooxidative C–H Functionalization of Heteroarenes. Thiocyanation of Pyrazolo[1,5‐a]pyrimidines

European journal of organic chemistry, 2019-07, Vol.2019 (26), p.4233-4238

2019

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Design, synthesis, and biological activity of novel spiro‐pyrazolo[1,5‐a]quinazolines derivatives as potential insecticides

Pest management science, 2023-03, Vol.79 (3), p.1164-1174

2023

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Synthesis, antibacterial activity and cytotoxicity of new fused pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-c][1,2,4]triazine derivatives from new 5-aminopyrazoles

European journal of medicinal chemistry, 2013-06, Vol.64, p.464-476

2013

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Synthesis of some novel pyrazolo[1,5-a]quinazolines and their fused derivatives

Synthetic communications, 2017-01, Vol.47 (2), p.148-158

2017

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Synthesis and photophysical properties of pyrazolo[1,5-a]pyrimidines containing D−π−A Architecture similar to Prodan

Journal of molecular structure, 2024-12, Vol.1317, p.139142, Article 139142

2024

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Synthesis of Pyrazolo[1,2-a]cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach

Advanced synthesis & catalysis, 2014-03, Vol.356 (5), p.972-976

2014

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Indium(III)chloride catalyzed synthesis of novel 1H-pyrazolo[1,2-b]phthalazine-5,10-diones and 1H-pyrazolo[1,2-a]pyridazine-5,8-diones under solvent-free condition

Tetrahedron letters, 2019-02, Vol.60 (7), p.560-565

2019

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Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold

European journal of medicinal chemistry, 2023-11, Vol.259, p.115674-115674, Article 115674

2023

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Preparation and characterization of nanomagnetic piperidinium benzene‐1,3‐disulfonate ionic liquid as a novel, green and heterogeneous catalyst and its use in the synthesis of 1H–pyrazolo[1,2‐b]phthalazine‐5,10‐diones and 1H–pyrazolo[1,2‐a] pyridazine‐5,8‐diones under solvent‐free conditions

Applied organometallic chemistry, 2017-10, Vol.31 (10), p.n/a

2017

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Domino protocol for the synthesis of diversely functionalized derivatives of a novel fused pentacyclic antioxidant/anticancer fluorescent scaffold: Pyrazolo[5'',1'':2',3']pyrimido[4',5':5,6][1,4]thiazino[2,3-b]quinoxaline

Talanta (Oxford), 2023-09, Vol.262, p.124723-124723, Article 124723

2023

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γ‐Fe2O3@Cu3Al‐LDH/HEPES a novel heterogeneous amphoteric catalyst for synthesis of annulated pyrazolo[3,4‐d]pyrimidines

Applied organometallic chemistry, 2022-10, Vol.36 (10), p.n/a

2022

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Pyrimidine-fused Dinitrogenous Penta-heterocycles as a Privileged Scaffold for Anti-Cancer Drug Discovery

The efficient in‐situ reduction and cyclization reaction of aromatic aldehyde, 1,3‐cyclopentanedione (tetronic acid), and nitro‐compound under SnCl2·2H2O‐THF medium

Synthesis and in vitro anticancer activity of pyrazolo[1,5-a]pyrimidines and pyrazolo[3,4-d][1,2,3]triazines

Synthesis and antimicrobial activity of some new heterocycles incorporating antipyrine moiety

Synthesis, anticancer activity and molecular docking of new pyrazolo[1,5-a]pyrimidine derivatives as EGFR/HER2 dual kinase inhibitors

Green synthesis of novel spiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-2,3′(7′H)- dione, spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3′-indoline]-2′,3-dione, and spiro[benzo [h]pyrazolo[3,4-b]quinoline-7,3′-indoline]-2′,8(5H)-dione derivatives in aqueous medium

Identification of indole-grafted pyrazolopyrimidine and pyrazolopyridine derivatives as new anti-cancer agents: Synthesis, biological assessments, and molecular modeling insights

Cyanide chemosensors based on 3-dicyanovinylpyrazolo[1,5-a]pyrimidines: Effects of peripheral 4-anisyl group substitution on the photophysical properties

Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses

Synthesis of some novel pyrazolo[3,4- b]pyridine and pyrazolo[3,4- d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents

Detrifluoromethylamination of trifluoromethyl pyrazolo[1,5-a]pyrimidins enabled by unusual C-CF3 bond cleavage

Caesium carbonate supported on hydroxyapatite-encapsulated Ni0.5Zn0.5Fe2O4 nanocrystallites as a novel magnetically basic catalyst for the one-pot synthesis of pyrazolo[1,2-b]phthalazine-5,10-diones

Stereoselective synthesis of dihydrothiadiazinoazines and dihydrothiadiazinoazoles and their pyrolytic desulfurization ring contraction

Regioselective synthesis and theoretical calculations of Bis(pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines) linked to benzofuran units via piperazine spacer: A DFT, MM2, and MMFF94 study

Electrooxidative C–H Functionalization of Heteroarenes. Thiocyanation of Pyrazolo[1,5‐a]pyrimidines

Design, synthesis, and biological activity of novel spiro‐pyrazolo[1,5‐a]quinazolines derivatives as potential insecticides

Synthesis, antibacterial activity and cytotoxicity of new fused pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-c][1,2,4]triazine derivatives from new 5-aminopyrazoles

Synthesis of some novel pyrazolo[1,5-a]quinazolines and their fused derivatives

Synthesis and photophysical properties of pyrazolo[1,5-a]pyrimidines containing D−π−A Architecture similar to Prodan

Synthesis of Pyrazolo[1,2-a]cinnolines via a Rhodium-Catalyzed Oxidative Coupling Approach

Indium(III)chloride catalyzed synthesis of novel 1H-pyrazolo[1,2-b]phthalazine-5,10-diones and 1H-pyrazolo[1,2-a]pyridazine-5,8-diones under solvent-free condition

Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold

Domino protocol for the synthesis of diversely functionalized derivatives of a novel fused pentacyclic antioxidant/anticancer fluorescent scaffold: Pyrazolo[5'',1'':2',3']pyrimido[4',5':5,6][1,4]thiazino[2,3-b]quinoxaline

γ‐Fe2O3@Cu3Al‐LDH/HEPES a novel heterogeneous amphoteric catalyst for synthesis of annulated pyrazolo[3,4‐d]pyrimidines

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