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An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist

Organic process research & development, 2016-05, Vol.20 (5), p.989-995

2016

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(Phenylsulfonyl)allenes as Substrates for Cycloaddition Reactions: Intramolecular Cyclizations onto Unactivated Alkenes

Journal of the American Chemical Society, 1995-07, Vol.117 (27), p.7071-7080

1995

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An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P 1 Receptor Agonist

Organic process research & development, 2016-05, Vol.20 (5), p.989-995

2016

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Peri and stereoselectivity effects in the intramolecular [2+2]-cycloaddition reaction of phenylsulfonyl-substituted allenes

Journal of the American Chemical Society, 1993-05, Vol.115 (9), p.3776-3777

1993

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Discovery of 6-Fluoro-5-( R )-(3-( S )-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4 H )-yl)-2-methylphenyl)-2-( S )-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1 H -carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.9173-9200

2016

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ChemInform Abstract: Novel Tricyclic Inhibitors of IKK2: Discovery and SAR Leading to the Identification of 2-Methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo [4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)

ChemInform, 2012-03, Vol.43 (11), p.no-no

2012

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Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-ylmethyl acetamide (BMS-066)

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (23), p.7006-7012

2011

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Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of I mu B kinase

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (10), p.2646-2649

2009

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Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis

The Journal of pharmacology and experimental therapeutics, 2009-11, Vol.331 (2), p.349

2009

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Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (10), p.2646-2649

2009

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Peri- and stereoselectivity effects in the intramolecular 2 + 2-cycloaddition reaction of phenylsulfonyl-substituted allenes

Journal of the American Chemical Society, 1993-05, Vol.115 (9), p.3776-3777

1993

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Novel inhibitors of IMPDH

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (3), p.543-546

2003

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Novel tricyclic inhibitors of IkappaB kinase

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.1994-2005

2009

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[3+2]-ANIONIC ELECTROCYCLIZATION USING 2,3-BIS(PHENYLSULFONYL)-1,3-BUTADIENE: trans-4,7,7-TRICARBOMETHOXY-2-PHENYLSULFONYLBICYCLO[3.3.0]OCT-1-ENE

Organic syntheses, 1997, Vol.74, p.147

1997

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2,3-DIBROMO-1-(PHENYLSULFONYL)-1-PROPENE AS A VERSATILE REAGENT FOR THE SYNTHESIS OF FURANS AND CYCLOPENTENONES: 2-METHYL-4-[(PHENYL-SULFONYL)METHYL]FURAN AND 2-METHYL-3-[(PHENYLSULFONYL)METHYL]-2-CYCLOPENTEN-1-ONE

Organic syntheses, 1997, Vol.74, p.115

1997

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Phenylsulfonyl Ene-Allenes as Efficient Precursors to Bicyclic Systems via Intramolecular [2 + 2]-Cycloaddition Reactions

ChemInform, 2003-12, Vol.34 (49), p.no-no

2003

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Novel Inhibitors of IMPDH: A Highly Potent and Selective Quinolone-Based Series

ChemInform, 2003-05, Vol.34 (21), p.no-no

2003

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Novel Amide-Based Inhibitors of Inosine 5′-Monophosphate Dehydrogenase

ChemInform, 2003-02, Vol.34 (8), p.no-no

2003

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ChemInform Abstract: Total Synthesis of (.+-.)-Ginkgolide B

ChemInform, 2000-02, Vol.31 (6), p.no-no

2000

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Descriptive Epidemiology of Generalized Anxiety Disorder in Canada/Épidémiologie descriptive du trouble d'anxiétégénéralisée au Canada

Canadian journal of psychiatry, 2017-01, Vol.62 (1), p.24

2017

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Rapid Application of the Molecular Clamp Platform for SARS-CoV-2

SSRN Electronic Journal

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An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist

(Phenylsulfonyl)allenes as Substrates for Cycloaddition Reactions: Intramolecular Cyclizations onto Unactivated Alkenes

An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P 1 Receptor Agonist

Peri and stereoselectivity effects in the intramolecular [2+2]-cycloaddition reaction of phenylsulfonyl-substituted allenes

ChemInform Abstract: Novel Tricyclic Inhibitors of IKK2: Discovery and SAR Leading to the Identification of 2-Methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo [4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)

Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-ylmethyl acetamide (BMS-066)

Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of I mu B kinase

Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase : Discovery and sar leading to the identification of N-2 -(6 -(4 -ethylpiperazin -L-yl )pyridin -3 -yl )propan -2 -yl -2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis

Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase

Peri- and stereoselectivity effects in the intramolecular 2 + 2-cycloaddition reaction of phenylsulfonyl-substituted allenes

Novel inhibitors of IMPDH

Novel tricyclic inhibitors of IkappaB kinase

[3+2]-ANIONIC ELECTROCYCLIZATION USING 2,3-BIS(PHENYLSULFONYL)-1,3-BUTADIENE: trans-4,7,7-TRICARBOMETHOXY-2-PHENYLSULFONYLBICYCLO[3.3.0]OCT-1-ENE

2,3-DIBROMO-1-(PHENYLSULFONYL)-1-PROPENE AS A VERSATILE REAGENT FOR THE SYNTHESIS OF FURANS AND CYCLOPENTENONES: 2-METHYL-4-[(PHENYL-SULFONYL)METHYL]FURAN AND 2-METHYL-3-[(PHENYLSULFONYL)METHYL]-2-CYCLOPENTEN-1-ONE

Phenylsulfonyl Ene-Allenes as Efficient Precursors to Bicyclic Systems via Intramolecular [2 + 2]-Cycloaddition Reactions

Novel Inhibitors of IMPDH: A Highly Potent and Selective Quinolone-Based Series

Novel Amide-Based Inhibitors of Inosine 5′-Monophosphate Dehydrogenase

ChemInform Abstract: Total Synthesis of (.+-.)-Ginkgolide B

Descriptive Epidemiology of Generalized Anxiety Disorder in Canada/Épidémiologie descriptive du trouble d'anxiétégénéralisée au Canada

Rapid Application of the Molecular Clamp Platform for SARS-CoV-2

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